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From FDA reports: drug interactions between Memantine Hcl, Propranolol, Aricept for a Female patient aged 78

This is a personalized study for a 78 year old female patient. The study is created by eHealthMe based on reports of 464 people who take the same drugs and have drug interactionsfrom FDA.

On Nov, 23, 2014: 464 people who reported to have interactions when taking Memantine Hcl, Propranolol, Aricept are studied

Trend of Memantine Hcl, Propranolol, Aricept's drug interactions, side effects, and effectiveness reports (3850130)

Information of the patient in this study:

Age: 78

Gender: female

Conditions: Dementia Alzheimer's Type

Drugs taking:
- Memantine Hcl: used for < 1 month
- Propranolol
- Aricept

Drug interactions have: Hallucination, Fear, Confusional State

eHealthMe real world results:

Comparison with this patient's adverse outcomes among females aged 78 (±5):

InteractionNumber of reports
Hallucination (an experience involving the perception of something not present)6 (4.88%)
Fear2 (1.63%)
Confusional State12 (9.76%)

Most common interactions experienced by females aged 78 (±5) in the use of Memantine Hcl, Propranolol, Aricept:

InteractionNumber of reports
Aspartate Aminotransferase Increased36
Torsade De Pointes (a abnormal heart rate with abnormal beating pattern)34
Alanine Aminotransferase Increased32
Drug Interaction30
Urinary Tract Infection30
Syncope (loss of consciousness with an inability to maintain postural tone)28
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)28
Electrocardiogram Qt Prolonged22
Abasia (inability to walk)22
Nausea (feeling of having an urge to vomit)20

Most common interactions experienced by females aged 78 (±5) in long term use of Memantine Hcl, Propranolol, Aricept:

InteractionNumber of reports
Bradycardia (abnormally slow heart action)7
Torsade De Pointes (a abnormal heart rate with abnormal beating pattern)6
Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)4
Pneumonia2
Loss Of Consciousness2
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)2
General Physical Health Deterioration (weak health status)2
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)2
Blood Creatine Phosphokinase Decreased2
Blood Albumin Decreased2

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Hallucination (an experience involving the perception of something not present)18 (3.88%)
Fear6 (1.29%)
Confusional State58 (12.50%)

Most common interactions experienced by people in the use of Memantine Hcl, Propranolol, Aricept:

InteractionNumber of reports
Fall90
Agitation (state of anxiety or nervous excitement)67
Nausea (feeling of having an urge to vomit)62
Confusional State58
Drug Interaction54
Aspartate Aminotransferase Increased48
Urinary Tract Infection47
Syncope (loss of consciousness with an inability to maintain postural tone)46
Dizziness46
Alanine Aminotransferase Increased44

Most common interactions experienced by people in long term use of Memantine Hcl, Propranolol, Aricept:

InteractionNumber of reports
Pneumonia12
Ileus (a painful obstruction of the ileum or other part of the intestine)11
Enterococcal Bacteraemia (presence of bacteria lactic acid in the blood)10
Portal Vein Thrombosis (venous thrombosis affecting the hepatic portal vein)10
Pancreatitis (inflammation of pancreas)10
Wound Infection10
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)10
Pancreatic Necrosis (death of pancreas tissue in pancreas)10
Pancreatic Pseudocyst (collection of tissue and fluids that forms on pancreas)8
Back Pain8

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 years ago):

  • Is this right taking Aspirin and Warfarin, sudden urinary incontinence

    Reply

Can you answer these questions (Ask a question):

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    UTI urinary frequency has non productive irritating cough and sarcoidosis associated with arthritis.
  • Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
    1)Coughing up Mucus
    2)Shortness of Breath
    3)Tightness in the Chest"

    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos
  • How do you cure tarry, black stools from aricept?
    I have had very dark, tarry stools since August. It's easy to find warnings about this side effect of Aricept but I have never heard and cannot find any suggestion for curing this condition. I would greatly appreciate knowing any actions that have cured this nuisance in other patients. Thanks in advance.

More questions for: Aricept, Confusional State, Dementia Alzheimer's Type, Fear, Hallucination

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  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
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More reviews for: Aricept, Confusional State, Dementia Alzheimer's Type, Fear, Hallucination

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In-depth study of side effects (who have it, when it happens and how):

Could it be a symptom from a condition:

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