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From FDA reports: drug interactions between Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab for a Male patient aged 70

This is a personalized study for a 70 year old male patient. The study is created by eHealthMe based on reports of 22 people who take the same drugs and have drug interactionsfrom FDA.

On Oct, 31, 2014: 22 people who reported to have interactions when taking Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab are studied

Trend of Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab's drug interactions, side effects, and effectiveness reports (3419164)

Information of the patient in this study:

Age: 70

Gender: male

Drugs taking:
- Prednisolone
- Methotrexate
- Chlorpheniramine Maleate: used for < 1 month
- Methylprednisolone 4mg Tab: used for < 1 month

Drug interactions have: Cerebrovascular Accident

eHealthMe real world results:

Comparison with this patient's adverse outcomes among males aged 70 (±5):

InteractionNumber of reports
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)2 (100.00%)

Most common interactions experienced by males aged 70 (±5) in the use of Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab:

InteractionNumber of reports
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)2

Most common interactions experienced by males aged 70 (±5) in long term use of Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab:

None.

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)4 (18.18%)

Most common interactions experienced by people in the use of Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab:

InteractionNumber of reports
Cytomegalovirus Test Positive22
Liver Disorder (liver diseases)20
Acute Graft Versus Host Disease In Skin (acute complication on skin following an allogeneic tissue/blood transplant)18
Pyrexia (fever)18
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)16
Haemolytic Anaemia (anaemia due to haemolysis)16
Cerebral Haemorrhage (bleeding within the brain)12
Diarrhoea12
Acute Respiratory Distress Syndrome (sudden failure of the respiratory (breathing) system)12
Urticaria (rash of round, red welts on the skin that itch intensely)10

Most common interactions experienced by people in long term use of Prednisolone, Methotrexate, Chlorpheniramine Maleate, Methylprednisolone 4mg Tab:

None.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 months ago):

  • Sarcoidosis caused complete heart block. Pacemaker implanted in December 2009 but for the past two years I have had palpitations caused by around 3.7 million ectopic heartbeats per year.

    Sarcoidosis also in lungs and eyes. Extended use of Pred Forte caused development of cataracts, one of which has been removed and I am awaiting the second operation.

    Breathlessness is caused by lack of oxygen entering the bloodstream and my ongoing heart problems

    Rarely able to sleep properly due to pain, sleeping for about 20 minutes at a time when I become so exhausted that the pain can't keep me awake

    Muscle and joint pain have made me weak and clumsy.Pain is felt all over, from head to toes along with muscle cramps and intense burning sensation to skin on lower legs.

    ACE levels fluctuate but average 110 - 150.

    Blood pressure on average is 150 / 78 - no treatment given

    I also take Nefopam Hydrochloride (Acupan) for pain but this drug is not on the list.

    Immobility, fatigue and constant pain have left me very depressed ad harbouring thoughts of suicide. My 15 year old granddaughter has lived with me since the death of my daughter 11 years ago and it is my hope that I will live long enough to see her settled in college and independent after which the only thing I have to look forward to is to end my own suffering.

    Reply

    IchikireiLV on Sep, 5, 2014:

    I was so sorry to read your comment, but glad I encountered it. PLEASE PLEASE don't ever think of taking your own life! I know what it is like to suffer. I injured myself 7 yrs ago, got a spinal implant that failed, compressed my spine, corroded and left me with heavy metal toxicity which caused adrenal failure, hypothyroid and many other serious health conditions. I have lived a life of chronic pain, fatigue and difficulty, so I know exactly where you are coming from! Some days I am so weak and have so much pain that I cannot get out of bed or care for myself. At times I try to puch myself to do the simplest things and my body is so frail I can barely catch my breath and feel like I gave to crawl back to my bed, dripping in sweat, dehydrated and defeated... but I still go on in hopes that there will be a better day. I ENCOURAGE YOU TO SEE A PAIN MANAGEMENT DR. MONTHLY FOR MEDICATIONS TO CONTROL YOUR PAIN! This alone will improve your daily life immensely! Pain will make you depressed! I also use Savella. It helps with Neuropathy pain AND DEPRESSION. Dont give up because doctors arent helping you enough. MAKE THEM! Its unacceptable that they are not following thru but I myself have experienced this many times.. Find another better, more compassionate Dr. Read Dr. reviews online, start with a primary care family dr, a pain dr and a rhuematologist for Sarcoidosis... make sure the Dr. is experienced with Sarcoidosis.. if not, find another one. I hope this helps you and gives you a direction to follow. Once your pain is controlled, things will be a lot better. Good luck and wishes of health and most of all HOPE and HAPPINESS 😄😄

    Reply

    Kath Nugent on Aug, 26, 2014:

    I was diagnosed with Lymphatic Sarcoidosis 15 years ago. After massive weight loss, a node in my neck the size of a small egg, and at the same time an
    area of my gum opened up were i had a tooth removed 20 years earlier, Sarcoid grew out of this opening !!it was like a piece of green string. My GP & Consultant tried to pull it out but failed,it was about an inch long. i was sent away with no further appointment, So i went to see my Dentist who seemed to know what it was and sent me to the Hospital Dentist who did a jaw bone Scraping and arranged for the node in neck to be removed for biopsy, both biopsy came back as Sarcoidosis. i was then x rayed and was found to have it in on my lungs as well. at this point i had active Sarcoidosis in my Lymphatic system, bone, lungs. However it as never been active in my lungs !!! it did however eat away the inside of my nose, it attacked my eyes i almost went blind, i lost my balance,it was in my brain.
    i was so tired, and after so many steroids i was having a bad reaction to them in various organs and was taken of them. i did recover from this as the Sarcoid went dormant. i have recently been diagnosed with a brain tumor and raised platelets. given that Sarcoidosis is next door to Cancer and that i feel absolutely wasted and week!!! i am feeling anxious about the outcome of more tests. But we all have to go sometime and i know there are people out there worse than me !!! i send you all love & light and hope we can all have the strength to help each other through whatever is thrown at us!! not easy by any means. Happy to answer any questions if it will help anyone Take care Kath Nugent

    Reply

  • From this study (6 months ago):

  • only since Methotrexate has increased to 12.5mg / week
    I take plaquenil 200mg 2 x day
    arava 20mg 1 x day
    celebrex 200mg 1 x day
    prednisolone 6mg x day
    methotrexate 12.5mg 1 x week
    megafol 5mg 2 x week

    Reply

  • From this study (2 years ago):

  • Had first Rituxan infusion yesterday

    Reply

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