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What could cause Edema, Pain In Limb for a 52-year old woman who takes Lyrica, Demerol, Soma?





Summary: 277 female patients aged 52 (±5) who take the same drugs are studied.

This is a personalized study for a 52 year old female patient who has Fibromyalgia. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)

Demerol has active ingredients of meperidine hydrochloride. It is often used in pain. (latest outcomes from Demerol 4,936 users)

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. (latest outcomes from Soma 9,565 users)

What are the conditions

Fibromyalgia (a long-term condition which causes pain all over the body) can be treated by Lyrica, Cymbalta, Savella, Gabapentin, Amitriptyline Hydrochloride, Flexeril. (latest reports from Fibromyalgia 26,862 patients)

What are the symptoms

Edema (excess of watery fluid collecting in the cavities or tissues of the body) has been reported by people with high blood pressure, pain, rheumatoid arthritis, osteoporosis, metastases to bone.(latest reports from Edema 21,478 patients)

Pain in limb has been reported by people with high blood cholesterol, hyperlipidaemia, pain, rheumatoid arthritis, high blood pressure.(latest reports from Pain in limb 11,558 patients)

On Nov, 22, 2014: 277 females aged 51 (±5) who take Lyrica, Demerol, Soma are studied

Lyrica, Demerol, Soma outcomes

Information of the patient in this study:

Age: 51

Gender: female

Conditions: Fibromyalgia

Drugs taking:
- Lyrica (pregabalin): used for 1 - 2 years
- Demerol (meperidine hydrochloride): used for 1 - 2 years
- Soma (carisoprodol): used for 1 - 2 years

Drug interactions have: moderate edema, severe pain in limb

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports on eHealthMe
Edema (excess of watery fluid collecting in the cavities or tissues of the body)27 (9.75% of females aged 51 (±5) who take the drugs)
Pain In Limb2 (0.72% of females aged 51 (±5) who take the drugs)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports on eHealthMe
Edema in Fibromyalgia42 (0.85% of females aged 51 (±5) who have Fibromyalgia)
Pain In Limb in Fibromyalgia3 (0.06% of females aged 51 (±5) who have Fibromyalgia)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports on eHealthMe
Edema in Lyrica132 (1.77% of females aged 51 (±5) who take Lyrica)
Edema in Demerol19 (3.39% of females aged 51 (±5) who take Demerol)
Edema in Soma48 (2.47% of females aged 51 (±5) who take Soma)
Pain In Limb in Lyrica3 (0.04% of females aged 51 (±5) who take Lyrica)
Pain In Limb in Demerol6 (1.07% of females aged 51 (±5) who take Demerol)
Pain In Limb in Soma7 (0.36% of females aged 51 (±5) who take Soma)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
n/an/a
Demerol is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/a100.00%
(1 of 1 people)
n/a
Soma is effective0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/a33.33%
(1 of 3 people)
n/a66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Malaise (a feeling of general discomfort or uneasiness)Ileus (a painful obstruction of the ileum or other part of the intestine)Nausea (feeling of having an urge to vomit)DizzinessHypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)Neuropathic Pain (pain due to nerve inflammation and damage)SwellingPain
Dyspnoea (difficult or laboured respiration)Pulmonary MassDiarrhoeaArthralgia (joint pain)Weight IncreasedBurning Feet Syndrome (burning sensation in the sole of the foot)Hormone Level AbnormalNausea (feeling of having an urge to vomit)
PainMental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)Malaise (a feeling of general discomfort or uneasiness)West Nile Viral InfectionIntervertebral Disc Protrusion (spinal disc protrusion)Weight IncreasedOedema Peripheral (superficial swelling)
Road Traffic AccidentLoss Of ConsciousnessProductive CoughAsthenia (weakness)Proctalgia (pain in the rectum)Fungal InfectionFatigue (feeling of tiredness)
Influenza Like IllnessHypoxia (low oxygen conditions)Hyperhidrosis (abnormally increased sweating)Vision BlurredRestless Legs Syndrome (a powerful urge to move your legs)Burning Feet Syndrome (burning sensation in the sole of the foot)Dyspnoea (difficult or laboured respiration)
Oropharyngeal PainAnaemia (lack of blood)Oropharyngeal PainSomnolence (a state of near-sleep, a strong desire for sleep)Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)Autoimmune Deficiency SyndromeAnxiety
Nausea (feeling of having an urge to vomit)PneumoniaUpper-airway Cough SyndromeRed Blood Cell Sedimentation Rate IncreasedIntervertebral Disc Disorder (spinal disc disorder)Neuropathic Pain (pain due to nerve inflammation and damage)Weight Increased
Productive CoughPainCoughWeight DecreasedSyncope (loss of consciousness with an inability to maintain postural tone)Diarrhoea
Muscular Weakness (muscle weakness)OverdoseInfluenza Like IllnessDiarrhoeaMalaise (a feeling of general discomfort or uneasiness)Malaise (a feeling of general discomfort or uneasiness)
Upper Respiratory Tract InfectionVision BlurredPyrexia (fever)Muscle Spasms (muscle contraction)Back DisorderVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and have Edema
- support group for people who take Demerol and have Edema
- support group for people who take Soma and have Edema
- support group for people who take Lyrica and have Pain In Limb
- support group for people who take Demerol and have Pain In Limb
- support group for people who take Soma and have Pain In Limb
- support group for people who have Edema and Fibromyalgia
- support group for people who have Pain In Limb and Fibromyalgia
- support group for people who have Fibromyalgia
- support group for people who have Edema
- support group for people who have Pain In Limb
- support group for people who take Demerol
- support group for people who take Lyrica
- support group for people who take Soma

Recent conversations of related support groups:

  • Support group for people who have Fibromyalgia
    Welcome Gigi and everyone! Anyone have any input on what makes living with Fibromyalgia more bearable?
  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

  • What is the highest dose of demerol i can take at once and still be safe?
    I had major reconstructive back surgery
    With 2 titanium replaced vertebrae
    Fusion and pins holding 2 broken facet joints
    Together. I have post surgical herniation in
    Remaining vertebrae and post surgical nerve damage
    Radiating down both legs. Since Vicodin 750/750 has been taken off the market
    Nothing is helping me. My pain mgmt doctor is trying
    To help, but that means trying something new at a relatively low dose for a month then
    Reassessing. Which means I'm miserable for a month at a time if it's not working
    I'm almost out of options because nothing seems to be helping
    Years ago I had luck with Demerol injections in the hospital so I agreed to try Demerol pills now I'm stuck again with something that's not working. So my question is how many MHD of Demerol can I take at one time and still be safe. I have to survive until my next pain management appt June 4th
    And I'm in excrutiating pain. Any body know? Thank you
  • Has anyone ever had anxiety attacks while taking miralax? (1 answer)
    I have been using Miralax for at least a year,with no problem.Now,I'm having anxiety attacks & my head itches all the time & I do not have dandruff...Is there anyone who has had anything like this while using Miralax (Polyethylene). HELP!!I'M MISERABLE!!!I have to take something for constipation,but I don't know what to do,if it is the Miralax causing my problems.
  • I developed excessive saliva production after starting ropinerole (requip) for plmd. sleep was impossible due to frequent swallowing. has anyone else experienced similar symptoms? (1 answer)
    The first 5 drugs above on my list that I tried for PLMD, I no longer use. I took ropinerole (Requip) for about 2 weeks when I noticed that I was producing more saliva and was swallowing a lot. It didn't really bother me too much, because the other drugs that I take give me a dry mouth. When I went to bed, trying to get to sleep was impossible, I had to swallow every 10 – 15 seconds all night long. My doctor investigated and found that only 1% of patients develop this symptom, lucky me. I discontinued using it. The symptom went away, and then came back even after I had stopped taking the drug for over 1 month. Has anyone else experienced this over-production of saliva during and/or after discontinuing ropinerole (Requip)? And if so, how long did it last and what can be done about it? It is disturbing my sleep so much that it of itself has become a sleep disorder. Any suggestions?
  • Do you ever have a tic with speech difficulty
    I was in the hospital on life support with TTP, I was given chemo as a part of my treatment, I survived :) I previously had breast cancer with Chemo..... This has left me with chemo-fibromyalgia. I am taking 225mg Lyrica twice a day... at times i have what i have a speech tic...feels like electrical energy racing through me.

    Does anyone else experience this
  • Is there any literature on lyrica and memory loss?
    Take Lyrica for 3 years now (2010- 2013)for severe Fibromyalgia related pain. Pre-diabetic symptoms since 2012. Relief from constant pain, pain comes mostly at night now, but I am able to finally sleep. Not restful, deep rem sleep but my brain slows down and I'm not making videos in my brain all night long. No dreams now, but no dreams before either.

    Had side effects of lose teeth, but that has since stopped and teeth are again healthy again. Had ringing in ear, and blurred vision, but hat has subsided after the first year. Had legs swell at ankles and feet but that has since stopped to.

    Generally Lyrica has been good at taking the daily Fibro wide-spread body pains away but my one torment is my loss of memory. I feel as if my brain is fried! My neuro-transmittters are not transmitting. There seems to be breaks in the memories and my ability to form new memories as well as pull forth old ones. I fear that this is permanent and when I try to do brain games and puzzles my head actually hurts! I know is sounds weird but this is my experience while one Lyrica. I also have taken muscle relaxers while on Lyrica. Flexeril and another one before that, can't remember the name of it now. I have taken opiods with Lyrica in the past but now I only take 50 mg of Tramadol twice a day. I am on 200 mg of Lyrica a day. 150mg at night and one 50 mg pill in the morning. If I don't take the morning pill my brain will not work at all.

More questions for: Demerol, Edema, Fibromyalgia, Lyrica, Pain In Limb, Soma

You may be interested at these reviews (Write a review):

  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Nightmare on lyrica st.
    r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyrica 2 weeks ago now up to 120 mg.With perks 4 times a day. The title says it all when trying to sleep :( my dream hands down beat any horror movies and directors. 2 hours of sleep per night and overly beat down :(.the only 2 good things I have going,my since of silliness and the Lord :) I guess family also.so far not much help with meds but willingly and pos, that both will work, the Lord :) thanks and God bless
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Demerol, Edema, Fibromyalgia, Lyrica, Pain In Limb, Soma

Comments from related studies:

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  • Thick uncomfortable ejaculations. Sometimes "chunks" of semen exit my penis durning bowel movements. Ejaculations look like gobs of tiny little round, very thick balls of semen making up large chunks of ejaculate...

    Reply

  • From this study (7 months ago):

  • Taking xarelto after knee surgery yesterday. Foot is now swollen on that leg and would like to know if I can take the bumetanide while taking xarelto.

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  • From this study (8 months ago):

  • Extremely thick, chunky like semen. Making it painful to ejaculate. Occasionally semen will come out during bowel movements in glob like increments. Ejaculations appear to be made up of small oblong jelly like balls, mixed together with semi vascular fluid.

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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