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From FDA reports: drug interactions between Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine for a Female patient aged 56

This is a personalized study for a 56 year old female patient. The study is created by eHealthMe based on reports of 2 people who take the same drugs and have drug interactionsfrom FDA.

On Dec, 20, 2014: 2 people who reported to have interactions when taking Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine are studied

Trend of Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine's drug interactions, side effects, and effectiveness reports (3475256)

Information of the patient in this study:

Age: 56

Gender: female

Conditions: Adenocarcinoma Pancreas

Drugs taking:
- Sorafenib: used for < 1 month
- Gemcitabine: used for < 1 month
- Sorafenib: used for < 1 month
- Sorafenib: used for < 1 month
- Gemcitabine: used for < 1 month
- Gemcitabine: used for < 1 month
- Midazolam Hcl: used for < 1 month
- Meperidine: used for < 1 month
- Glucagon: used for < 1 month
- Promethazine: used for < 1 month

Drug interactions have: Thrombocytopenia, Haemoglobin Decreased, Gastrointestinal Perforation, Dyspnoea, Diverticulitis

eHealthMe real world results:

Comparison with this patient's adverse outcomes among females aged 56 (±5):

InteractionNumber of reports
Thrombocytopenia (decrease of platelets in blood)2 (100.00%)
Haemoglobin Decreased2 (100.00%)
Gastrointestinal Perforation (hole in the digestive tract)2 (100.00%)
Dyspnoea (difficult or laboured respiration)2 (100.00%)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)2 (100.00%)

Most common interactions experienced by females aged 56 (±5) in the use of Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine:

InteractionNumber of reports
Thrombocytopenia (decrease of platelets in blood)2
Haemoglobin Decreased2
Gastrointestinal Perforation (hole in the digestive tract)2
Dyspnoea (difficult or laboured respiration)2
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)2

Most common interactions experienced by females aged 56 (±5) in long term use of Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine:

None.

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Thrombocytopenia (decrease of platelets in blood)2 (100.00%)
Haemoglobin Decreased2 (100.00%)
Gastrointestinal Perforation (hole in the digestive tract)2 (100.00%)
Dyspnoea (difficult or laboured respiration)2 (100.00%)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)2 (100.00%)

Most common interactions experienced by people in the use of Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine:

InteractionNumber of reports
Thrombocytopenia (decrease of platelets in blood)2
Haemoglobin Decreased2
Gastrointestinal Perforation (hole in the digestive tract)2
Dyspnoea (difficult or laboured respiration)2
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)2

Most common interactions experienced by people in long term use of Sorafenib, Gemcitabine, Midazolam Hcl, Meperidine, Glucagon, Promethazine:

None.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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  • Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
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    2)Shortness of Breath
    3)Tightness in the Chest"

    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!

More questions for: Adenocarcinoma Pancreas, Diverticulitis, Dyspnoea, Gastrointestinal Perforation, Gemcitabine, Glucagon, Haemoglobin Decreased, Promethazine, Thrombocytopenia

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Complete side effects:

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