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Review: Allopurinol side effects

In this review, we analyze Allopurinol side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Allopurinol. The review is based on 50,512 people who have side effects while taking Allopurinol from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who have Allopurinol side effects >>>

What is Allopurinol

Allopurinol (latest outcomes from 51,393 users) has active ingredients of allopurinol. It is often used in gout.

Other drugs that have the same active ingredients (allopurinol): Zyloprim, Lopurin.

On Jul, 22, 2014: 50,512 people who reported to have side effects when taking Allopurinol are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaBlood Creatinine IncreasedRenal Failure AcuteInterstitial Lung DiseaseDiarrhoeaPulmonary EmbolismDyspnoea
Renal Failure AcutePlatelet Count DecreasedPyrexiaAnaemiaRenal Failure AcuteC-reactive Protein IncreasedWeight DecreasedAnaemia
Stevens-johnson SyndromeRenal Failure AcuteGeneral Physical Health DeteriorationBlood Creatinine IncreasedPyrexiaPleural EffusionTinnitusPain
Renal FailureAnaemiaRenal Failure AcuteDiarrhoeaRenal FailureDecreased AppetiteOsteomyelitisNausea
HypotensionDrug Rash With Eosinophilia And Systemic SymptomsRenal FailureRenal FailureDiarrhoeaDyspnoeaDyspnoeaFatigue
PneumoniaDiarrhoeaAnaemiaDehydrationBlood Creatine Phosphokinase IncreasedInterstitial Lung DiseaseLeukopeniaRenal Failure Acute
Febrile NeutropeniaStevens-johnson SyndromeRenal ImpairmentRenal ImpairmentAtrial FibrillationRenal FailureRenal FailureRenal Failure
ThrombocytopeniaRashCardiac FailureCardiac FailureRenal ImpairmentNauseaHypoxiaPyrexia
DiarrhoeaRenal FailurePancytopeniaAtrial FibrillationMyalgiaSyncopeOral HerpesAsthenia

Most common side effects by gender * :

Renal Failure AcuteRenal Failure Acute
AstheniaRenal Failure

Most common side effects by age * :

Toxic Epidermal NecrolysisPyrexiaHepatotoxicityPyrexiaPyrexiaPyrexiaPyrexiaRenal Failure Acute
Premature BabyCoughBlood Bilirubin IncreasedFebrile NeutropeniaFatigueNauseaNauseaPyrexia
Hypoglycaemia NeonatalTumour Lysis SyndromeDilatation Intrahepatic Duct AcquiredPlatelet Count DecreasedHeadacheDyspnoeaDiarrhoeaDyspnoea
Neonatal Respiratory Distress SyndromeNeutropeniaAlanine Aminotransferase IncreasedNauseaAlanine Aminotransferase IncreasedPainDyspnoeaNausea
Jaundice NeonatalFebrile NeutropeniaLiver Function Test AbnormalDyspnoeaAnxietyFatigueFatigueAnaemia
Foetal Cerebrovascular DisorderAttention Deficit/hyperactivity DisorderPyrexiaVomitingNauseaRenal Failure AcuteAnaemiaDiarrhoea
Placental DisorderCytomegalovirus InfectionHypotensionAlanine Aminotransferase IncreasedHypotensionDiarrhoeaPainRenal Failure
PyrexiaRenal Failure AcuteVenoocclusive Liver DiseaseDiarrhoeaMalaiseAstheniaRenal Failure AcuteAsthenia
ChloromaVenoocclusive Liver DiseaseBlood Alkaline Phosphatase IncreasedAspartate Aminotransferase IncreasedDizzinessBlood Creatinine IncreasedOedema PeripheralFatigue
Foetal Growth RestrictionChronic SinusitisRenal FailureWhite Blood Cell Count DecreasedAspartate Aminotransferase IncreasedArthralgiaHypotensionBlood Creatinine Increased

* Some reports may have incomplete information.

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Comments from related studies:

  • From this study (1 week ago):

  • Also have decreased kidney function 25% of kidneys are functioning. When I went in the hospital in May 2014 , 2 small blood clots were found ( lung and also in right leg ) Plus I had Gout and continued to have pain in the knee and swelling in right leg. Now I am ok, but still taking 5 mg of prednisone (for a 10 day period) I was taking prednisone while in the hospital as well and after when I returned home continued. I went to the Rheumatologist and he didnt like the way the hospital dispensed the medication. (He said it took too long the way it had been prescribed) So he told me not to continue it that way and to follow it his way so he increased the dosage to 40 mg and then tapered to 20 and then to 10 mg. off for a total 6 days, but i was still in pain in my knee and swelling. He told me to continue for a 10 day period 5 mg. but i still had some pain and swelling. He told me to do another 10 day period with 5 mg . The reason is I had to be attack free in order to start my 50 mg of Allopurinol 3 times a week which I started today. I dont have any pain in my right leg but it still swells a little when I am walking a lot, but when I elevate it, swelling goes down and leg is normal. At night, I sleep with a pillow under my legs which helps. The other thing is my kidney doctor wants to put me on Calcitriol (Vit. D) He wants to do this in September and I want to know is this ok to take because of my "decreased kidney function"? My calcium blood level is 9.0 right now and previous blood reports Calcium levels were 9.2, 8.6, 9.4 and 9.1 Wouldnt this be considered a normal calcium level. I understand that too much calcium in the blood is not good. I also wanted to mention that I have high blood pressure for many years and when I went in the hospital, they took me off the High blood pressure medication Quinapril (20 mg) and I am still off it. I lost 15 lbs and BP pressure is about 130/70 but eventually Dr. wants to put me back on it. As for the Hyperparathyroidism which was was shown on my last blood test that i took. Is it possible that the Prednisone that I have been taking could have caused this? I appreciate any help you can give me on the above. Thank you.


  • From this study (1 week ago):

  • During exertion, experience shortness of breath and burning in leg muscles. Observed low heart rate.


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  • Allopurinol and muscle cramps
    Approximately 5 years ago I developed gout and my physician prescribed allopurinol. After a period of time I began to have muscle spasms in the calves of my legs at night. My doctor gave me a prescription for restless leg syndrome, which helped for a short time. I was then given a different presc ...

More reviews for: Allopurinol

On eHealthMe, Allopurinol (allopurinol) is often used for gout. Find out below the conditions Allopurinol is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Allopurinol used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Allopurinol drug interactions:

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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