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Review: Allopurinol side effects

In this review, we analyze Allopurinol side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Allopurinol. The review is based on 50,566 people who have side effects while taking Allopurinol from FDA and social media, and is updated regularly.

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What is Allopurinol

Allopurinol (latest outcomes from 51,452 users) has active ingredients of allopurinol. It is often used in gout.

Other drugs that have the same active ingredients (allopurinol): Zyloprim, Lopurin.

On Jan, 13, 2015: 50,566 people who reported to have side effects when taking Allopurinol are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pyrexia (fever)Pyrexia (fever)Blood Creatinine IncreasedRenal Failure Acute (rapid kidney dysfunction)Interstitial Lung DiseaseDiarrhoeaPulmonary Embolism (blockage of the main artery of the lung)Dyspnoea (difficult or laboured respiration)
Renal Failure Acute (rapid kidney dysfunction)Platelet Count DecreasedPyrexia (fever)Anaemia (lack of blood)Renal Failure Acute (rapid kidney dysfunction)C-reactive Protein IncreasedWeight DecreasedAnaemia (lack of blood)
Sepsis (a severe blood infection that can lead to organ failure and death)PneumoniaGeneral Physical Health Deterioration (weak health status)Pyrexia (fever)Pyrexia (fever)Pyrexia (fever)PneumoniaDiarrhoea
Stevens-johnson Syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)Renal Failure Acute (rapid kidney dysfunction)Rash (redness)Blood Creatinine IncreasedThrombocytopenia (decrease of platelets in blood)Pleural Effusion (water on the lungs)Tinnitus (a ringing in the ears)Pain
Renal Failure (kidney dysfunction)Anaemia (lack of blood)Renal Failure Acute (rapid kidney dysfunction)DiarrhoeaRenal Failure (kidney dysfunction)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)Osteomyelitis (infection of bone)Nausea (feeling of having an urge to vomit)
Hypotension (abnormally low blood pressure)Drug Rash With Eosinophilia And Systemic Symptoms (adverse drug reactions with rash)Renal Failure (kidney dysfunction)Renal Failure (kidney dysfunction)DiarrhoeaInterstitial Lung DiseaseDyspnoea (difficult or laboured respiration)Fatigue (feeling of tiredness)
PneumoniaDiarrhoeaAnaemia (lack of blood)Dehydration (dryness resulting from the removal of water)Blood Creatine Phosphokinase IncreasedNausea (feeling of having an urge to vomit)Leukopenia (less number of white blood cells in blood)Renal Failure Acute (rapid kidney dysfunction)
Febrile Neutropenia (fever with reduced white blood cells)Stevens-johnson Syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)Renal Impairment (severely reduced kidney function)Renal Impairment (severely reduced kidney function)Atrial Fibrillation (fibrillation of the muscles of the atria of the heart)Renal Failure (kidney dysfunction)Renal Failure (kidney dysfunction)Renal Failure (kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)Rash (redness)Cardiac FailureCardiac FailureRenal Impairment (severely reduced kidney function)Dyspnoea (difficult or laboured respiration)Hypoxia (low oxygen conditions)Pyrexia (fever)
DiarrhoeaRenal Failure (kidney dysfunction)Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)Fatigue (feeling of tiredness)Renal Failure Chronic (long lasting kidney dysfunction)Syncope (loss of consciousness with an inability to maintain postural tone)Oral Herpes (viral infection of mouth)Asthenia (weakness)

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Pyrexia (fever)
Pyrexia (fever)Dyspnoea (difficult or laboured respiration)
Renal Failure Acute (rapid kidney dysfunction)Renal Failure Acute (rapid kidney dysfunction)
Anaemia (lack of blood)Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)Fatigue (feeling of tiredness)
Asthenia (weakness)Renal Failure (kidney dysfunction)
Fatigue (feeling of tiredness)Anaemia (lack of blood)
PainAsthenia (weakness)

Most common side effects by age * :

Toxic Epidermal Necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)Pyrexia (fever)Hepatotoxicity (chemical-driven liver damage)Pyrexia (fever)Pyrexia (fever)Pyrexia (fever)Pyrexia (fever)Renal Failure Acute (rapid kidney dysfunction)
Premature BabyCoughBlood Bilirubin IncreasedFebrile Neutropenia (fever with reduced white blood cells)Fatigue (feeling of tiredness)Nausea (feeling of having an urge to vomit)Nausea (feeling of having an urge to vomit)Pyrexia (fever)
Hypoglycaemia Neonatal (deficiency of glucose in the bloodstream in neonatal)Tumour Lysis Syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)Dilatation Intrahepatic Duct AcquiredPlatelet Count DecreasedHeadache (pain in head)Dyspnoea (difficult or laboured respiration)DiarrhoeaDyspnoea (difficult or laboured respiration)
Neonatal Respiratory Distress Syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)Neutropenia (an abnormally low number of neutrophils)Alanine Aminotransferase IncreasedNausea (feeling of having an urge to vomit)Alanine Aminotransferase IncreasedPainDyspnoea (difficult or laboured respiration)Nausea (feeling of having an urge to vomit)
Jaundice Neonatal (yellowing of skin in neonate)Febrile Neutropenia (fever with reduced white blood cells)Liver Function Test AbnormalDyspnoea (difficult or laboured respiration)AnxietyFatigue (feeling of tiredness)Fatigue (feeling of tiredness)Anaemia (lack of blood)
Foetal Cerebrovascular Disorder (a group of brain dysfunctions related to disease of the blood vessels supplying the brain of foetus)Attention Deficit/hyperactivity DisorderPyrexia (fever)VomitingNausea (feeling of having an urge to vomit)Renal Failure Acute (rapid kidney dysfunction)Anaemia (lack of blood)Diarrhoea
Placental DisorderCytomegalovirus InfectionHypotension (abnormally low blood pressure)Alanine Aminotransferase IncreasedHypotension (abnormally low blood pressure)DiarrhoeaPainRenal Failure (kidney dysfunction)
Pyrexia (fever)Renal Failure Acute (rapid kidney dysfunction)Venoocclusive Liver Disease (small veins in the liver are obstructed)DiarrhoeaMalaise (a feeling of general discomfort or uneasiness)Asthenia (weakness)Renal Failure Acute (rapid kidney dysfunction)Asthenia (weakness)
Chloroma (green-coloured tumour)Venoocclusive Liver Disease (small veins in the liver are obstructed)Blood Alkaline Phosphatase IncreasedAspartate Aminotransferase IncreasedDizzinessBlood Creatinine IncreasedOedema Peripheral (superficial swelling)Fatigue (feeling of tiredness)
Foetal Growth Restriction (poor growth of a baby while in the mother's womb during pregnancy)Chronic Sinusitis (long lasting inflammation of the paranasal sinuses)Renal Failure (kidney dysfunction)White Blood Cell Count DecreasedAnaemia (lack of blood)Arthralgia (joint pain)Hypotension (abnormally low blood pressure)Blood Creatinine Increased

* Some reports may have incomplete information.

Browse Allopurinol side effects from A to Z:

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Comments from related studies:

  • From this study (4 days ago):

  • Rash on right forearm


  • From this study (1 month ago):

  • lab results show elevated BUN and Creatinine and elevated serum calcium


  • From this study (2 months ago):

  • I have been taking allopurinol (300mg) since 1990 and blood tests indicate an increase in serum ferritin from 288 to 410 ug/l over the past 18 months. I used to be a blood donor but have stopped since prostate cancer treatment four years ago.


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  • Allop├╝rinol and achilles tendinitis
    I take allopurinol on a purely prophylactic basis, as my father has got gout and kidney stones. Since three months I suffer from achilles tendinitis; I put it down to overload; I am rather heavy and play a lot of tennis, besides moving a lot at work. As always, I tried to "walk through" my weight associated problems, but it did not get any better. Non-compliant, I stopped taking allopurinol for the last three days, and, surprise surprise, the pain is quickly abating, in spite of playing prolonged matches the last three days. I remembered that gyrase inhibitors (e.g. ciprofloxacin) predispose to achilles tendon rupture, a fact that I was personal witness with a female player at our club. So I speculate on a causal link between allopurinol and achilles tendinitis
  • Allopurinol for 6-mp metabolism to 6-tgn
    I began taking Allopurinol 100mg to help metabolize the Purinethol I have been taking for 6 years for Crohn's disease after a blood test revealed my 6-MMP metabolites were too high and 6-TG were too low. Several published studies show Allopurinol to be helpful for "non-preferential metabolizers" like me, to help shunt the metabolic pathway towards therapeutic 6-TG.

    After 1 week of Allopurinol, I had to discontinue the drug due to debilitating nausea, which was worst in the morning.
  • Ear pain from allopurinol 100mg (1 response)
    I have just been prescribed 100mg Allopurinol.
    1 a day.
    I am in my second day of taking these tablets.
    I have begun to get get a sudden pain in my ear.
    I have never in all my years have ever had such a pain.
    I know the only change that has happened around me is taking these tablets.
    I have stopped taking these and am awaiting my next appt with my GP.
    I do take Arcoxia with paracetemol for pain relief.
  • Allopurinol and muscle cramps
    Approximately 5 years ago I developed gout and my physician prescribed allopurinol. After a period of time I began to have muscle spasms in the calves of my legs at night. My doctor gave me a prescription for restless leg syndrome, which helped for a short time. I was then given a different prescription when that one no longer helped, and finally a third prescription, which did not work either. The cramps continued to grow more severe and more frequent. I was also having extremely severe cramps in my left hand, to the point that I could not straighten my fingers for several excruciating minutes. Although the cramps in my calves had lessened significantly, my toes were starting to cramp severely.

    I stopped taking allopurinol about a month ago, and since then I realized that my hands and toes were cramping less and less, and now it is almost completely gone. I inadvertently stopped the allopurinol and I lost the bottle of pills and didn't realize it until I went to refill my pill box that holds a month's supply divided into daily doses. I searched on the internet and found that muscle problems are not uncommon for some people taking allopurinol.

More reviews for: Allopurinol

On eHealthMe, Allopurinol (allopurinol) is often used for gout. Find out below the conditions Allopurinol is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Allopurinol used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Allopurinol drug interactions:

Browse Allopurinol drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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