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Review: Amitriptyline hydrochloride side effects

In this review, we analyze Amitriptyline hydrochloride side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Amitriptyline hydrochloride. The review is based on 5,749 people who have side effects while taking Amitriptyline hydrochloride from FDA and social media, and is updated regularly.

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What is Amitriptyline hydrochloride

Amitriptyline hydrochloride (latest outcomes from 7,179 users) has active ingredients of amitriptyline hydrochloride. It is often used in depression.

Other drugs that have the same active ingredients (amitriptyline hydrochloride): Elavil, Endep, Amitril, Amitid.

On Jan, 29, 2015: 5,749 people who reported to have side effects when taking Amitriptyline hydrochloride are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coma (state of unconsciousness lasting more than six hours)Panic AttackHypertension (high blood pressure)DizzinessCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)Fatigue (feeling of tiredness)Short-term Memory LossNausea (feeling of having an urge to vomit)
FallArthralgia (joint pain)Mood Swings (an extreme or rapid change in mood)Confusional StateAnxietyTemporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)DizzinessFatigue (feeling of tiredness)
DepressionIrritable Bowel SyndromeLethargy (tiredness)Dry MouthOsteonecrosis (death of bone)Fistula (an abnormal connection or passageway between two)Hair LossFall
Suicide AttemptNausea (feeling of having an urge to vomit)Pancreatitis (inflammation of pancreas)Tremor (trembling or shaking movements in one or more parts of your body)Blood Creatine Phosphokinase IncreasedDrug Administration ErrorDiarrheaArthralgia (joint pain)
Hallucination (an experience involving the perception of something not present)DiarrhoeaNausea (feeling of having an urge to vomit)Insomnia (sleeplessness)Eye PainOsteitis Deformans (a disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain)Itching ScarAnxiety
Restlessness (not able to rest)Heart Rate IncreasedVomitingAbnormal Behaviour NosAmnesia (deficit in memory caused by brain damage, disease, or psychological trauma)InfectionRash Generalised (rash on most of body parts)Dyspnoea (difficult or laboured respiration)
Syncope (loss of consciousness with an inability to maintain postural tone)Abdominal Pain UpperHeart Rate IncreasedRectal Bleeding (bleeding from rectum)Arthralgia (joint pain)Herpes ZosterTremor (trembling or shaking movements in one or more parts of your body)Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)Hypertension (high blood pressure)Chest PainDisorientation (disability in which the senses of time, direction, and recognition of people and places)Blood Cholesterol IncreasedOsteomyelitis (infection of bone)ConfusionPain
DizzinessDizzinessPregnancyAnticholinergic Syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)Haematochezia (passage of stools containing blood)PainNight Sweats (sweating in night)Depression
Somnolence (a state of near-sleep, a strong desire for sleep)Reflexes Abnormal (body receives a certain stimulus not normally)Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)Condition AggravatedTinnitus (a ringing in the ears)Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints)Gastro-oesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)Dizziness

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Pyrexia (fever)
FallFatigue (feeling of tiredness)
Fatigue (feeling of tiredness)Fall
Arthralgia (joint pain)Headache (pain in head)
Pyrexia (fever)Depression
DepressionConfusional State
Dyspnoea (difficult or laboured respiration)Anxiety
AnxietyNausea (feeling of having an urge to vomit)

Most common side effects by age * :

Maternal Drugs Affecting Foetus (chemical affecting the baby before birth taken by mother)AsthmaAbdominal PainPyrexia (fever)Nausea (feeling of having an urge to vomit)Nausea (feeling of having an urge to vomit)Fatigue (feeling of tiredness)Fall
Hypertriglyceridaemia (excess of triglycerides in the blood)Nasopharyngitis (inflammation of the nasopharynx)Headache (pain in head)Suicide AttemptDepressionFatigue (feeling of tiredness)FallNausea (feeling of having an urge to vomit)
Poisoning DeliberatePallor (unusual lightness of skin colour)Heart Rate IncreasedHeadache (pain in head)Chest PainDrug IneffectivePyrexia (fever)Pyrexia (fever)
Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration)Respiratory Disorder Nos (respiratory disease)Drug IneffectiveSerotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)DizzinessPainDepressionArthralgia (joint pain)
Neutropenia (an abnormally low number of neutrophils)SedationAbasia (inability to walk)Drug ToxicityAnxietyDepressionNausea (feeling of having an urge to vomit)Fatigue (feeling of tiredness)
Drug Withdrawal Syndrome Neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)Facial Palsy (paralysis of face nerve)Tremor (trembling or shaking movements in one or more parts of your body)Hypotension (abnormally low blood pressure)Dyspnoea (difficult or laboured respiration)VomitingAnxietyDyspnoea (difficult or laboured respiration)
Foetal Distress Syndrome (altered heart rate or rhythm and leading tocompromised blood flow or changes in blood chemistry of foetus)Hemiparesis (weakness on one side of the body)Abdominal Pain UpperIntentional OverdoseSuicide AttemptAnxietyHeadache (pain in head)Asthenia (weakness)
Drug Exposure During PregnancyHypotonia (low muscle tone)IrritabilitySomnolence (a state of near-sleep, a strong desire for sleep)Fatigue (feeling of tiredness)DizzinessDizzinessAnxiety
Blood Creatinine IncreasedMydriasis (a dilation of the pupil)Pyrexia (fever)Loss Of ConsciousnessParaesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)Back PainPainDizziness
Foetal Growth Retardation (a baby in the womb fails to grow at the expected rate during the pregnancy)Tremor Nec (trembling or shaking movements in one or more parts of your body)Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)Arthralgia (joint pain)VomitingHeadache (pain in head)Drug IneffectiveDiarrhoea

* Some reports may have incomplete information.

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Are you taking Amitriptyline hydrochloride?

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used for depression. Find out below the conditions Amitriptyline Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Amitriptyline Hydrochloride used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Amitriptyline hydrochloride drug interactions:

Browse Amitriptyline hydrochloride drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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