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Review: Amitriptyline side effects

In this review, we analyze Amitriptyline hydrochloride side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Amitriptyline hydrochloride. The review is based on 5,695 people who have side effects while taking Amitriptyline hydrochloride from FDA and social media, and is updated regularly.

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What is Amitriptyline hydrochloride

Amitriptyline hydrochloride (latest outcomes from 7,109 users) has active ingredients of amitriptyline hydrochloride. It is often used in migraine.

Other drugs that have the same active ingredients (amitriptyline hydrochloride): Elavil, Endep, Amitril, Amitid.

On Sep, 25, 2014: 5,695 people who reported to have side effects when taking Amitriptyline hydrochloride are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ComaPanic AttackHypertensionDry MouthCerebrovascular AccidentFistulaDizzinessNausea
FallIrritable Bowel SyndromeMood SwingsDizzinessAnxietyFatigueDiarrheaFatigue
DepressionArthralgiaLethargyConfusional StateOsteonecrosisTemporomandibular Joint SyndromeShort-term Memory LossFall
Suicide AttemptNauseaPancreatitisTremorDisturbance In AttentionDrug Administration ErrorTremorArthralgia
HallucinationDiarrhoeaVomitingInsomniaDrug HypersensitivityOsteitis DeformansConfusionAnxiety
RestlessnessHeart Rate IncreasedNauseaHyponatraemiaBlood Creatine Phosphokinase IncreasedArthropathyRash GeneralisedDyspnoea
TremorHypertensionDizzinessRectal BleedingWeight DecreasedOsteomyelitisHair LossHeadache
SyncopeAbdominal Pain UpperPregnancyAnorexiaArthralgiaInfectionNight SweatsPain
ConvulsionReflexes AbnormalMental Status ChangesDyspnoeaBlood Cholesterol IncreasedPainItching ScarDepression
SomnolenceDizzinessChest PainHair LossDyspnoeaRheumatoid ArthritisMental Status ChangesDizziness

Most common side effects by gender * :

DepressionConfusional State

Most common side effects by age * :

Maternal Drugs Affecting FoetusAsthmaAbdominal PainPyrexiaNauseaNauseaFatigueFall
MacrocytosisNasopharyngitisHeadacheSuicide AttemptDepressionFatigueFallNausea
HypertriglyceridaemiaPallorHeart Rate IncreasedSerotonin SyndromeChest PainDrug IneffectivePyrexiaPyrexia
NeutropeniaRespiratory Disorder NosDrug IneffectiveDrug ToxicityDizzinessPainDepressionArthralgia
Drug Withdrawal Syndrome NeonatalSedationAbasiaHeadacheAnxietyDepressionNauseaFatigue
Poisoning DeliberateFacial PalsyTremorHypotensionDyspnoeaVomitingAnxietyDyspnoea
Foetal Distress SyndromeHemiparesisAbdominal Pain UpperIntentional OverdoseSuicide AttemptAnxietyHeadacheAsthenia
Drug Exposure During PregnancyHypotoniaIrritabilityArthralgiaFatigueBack PainPainAnxiety
Blood Creatinine IncreasedMydriasisPyrexiaLoss Of ConsciousnessParaesthesiaDizzinessDizzinessDizziness
Foetal Growth RetardationTremor NecCardio-respiratory ArrestCondition AggravatedVomitingHeadacheDrug IneffectiveDiarrhoea

* Some reports may have incomplete information.

Browse Amitriptyline hydrochloride side effects from A to Z:

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Are you taking Amitriptyline hydrochloride?

Comments from related studies:

  • From this study (1 day ago):

  • Elavil, 25mg @ night stopped an 11 month chronic headache after a head injury, I sustained 1 1/2 years ago.
    Additionally, Neurologist prescribed 100 mg Lyrica for chronic back/nerve pain from moderate/severe spinal injuries, sustained 20+ years earlier. (Crushed/cracked verabrae and 3 intervertebral disc bulges)
    I had been using Ibuprofen daily in moderate to heavy dosage for the last 20+ years. (800+ mg daily B/4 and then continually after recent head injury)
    I was advised to stop/reduce use of Motrin to 1/2 month or less. It is still the best pain relief but have reduced to PRN, perhaps 200 mg alternate days.
    Since treatment with Lyrica I've noticed reduced nerve pain and stopped using Elavil for sake of not feeling so "wrecked" in the mornings. I have also developed a severe sleep apnoea, treated unsuccessfully via CPAP device which is unbearable to use. I have subsequently suffered with depression/mood disorder for 20+ years and am currently un-treated for this long-standing vulnerability which came back with a vengence after the head-injury. I feel irregularity to my heart beat by the end of the day. I feel suicidal and violently angry.


    dutchgirlsamm on Aug, 30, 2014:

    Lyrics is known to cause suicidal thoughts and aggression...its called an adverse reaction.


  • From this study (3 days ago):

  • I took my pills yesterday night before I went to bed and I was fine then around two hours later I got extremely tired. I also feel s if I could do anything. Before I fell asleep I could feel my heart beat getting slower.


  • From this study (5 days ago):

  • I get diarrhoea only at night time. I take Endep only at night... and Lyrica 150mg at night (75mg in the morning)... and the Pristiq in the morning.


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More reviews for: Amitriptyline hydrochloride

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used for depression. Find out below the conditions Amitriptyline Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Amitriptyline Hydrochloride used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Amitriptyline hydrochloride drug interactions:

Browse Amitriptyline hydrochloride drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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