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Home > Health tools > Drug comparison > Estradiol vs Prometrium vs Prempro

Estradiol vs Prometrium vs Prempro, a side effect and effectiveness comparison for a female patient aged 63

This is personalized comparison of Estradiol vs Prometrium vs Prempro for a female aged 63. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Estradiol (latest outcomes from 4,821 users) has active ingredients of estradiol. It is often used in hormone replacement therapy.

Prometrium (latest outcomes from 3,631 users) has active ingredients of progesterone. It is often used in hormone replacement therapy.

Prempro (latest outcomes from 37,630 users) has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause.

On Oct, 29, 2014: 19,154 female patients aged 61 who take the same drugs are studied in Estradiol vs Prometrium vs Prempro

Information of patient in study:

GenderAgeReason for the drug
Female61Menopause

Drugs to compare:

DrugIngredientsCompany
Estradiol estradiolWatson Labs
Prometrium progesteroneUnimed Pharms
Prempro estrogens, conjugated; medroxyprogesterone acetateWyeth Pharms Inc

eHealthMe real world results:

For females aged 61 (±5):

Most common side effects:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Estradiol (Watson Labs)Prometrium (Unimed Pharms)Prempro (Wyeth Pharms Inc)
Breast CancerBreast CancerBreast Cancer
Breast Cancer FemaleNausea (feeling of having an urge to vomit)Breast Cancer Female
Nausea (feeling of having an urge to vomit)Breast Cancer FemaleBreast Cancer Metastatic
Fatigue (feeling of tiredness)Fatigue (feeling of tiredness)Oestrogen Receptor Assay Positive
Chest PainDepressionProgesterone Receptor Assay Positive
DepressionPainNausea (feeling of having an urge to vomit)
PainHeadache (pain in head)Breast Cancer In Situ
Drug IneffectiveDrug IneffectiveCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Oestrogen Receptor Assay PositiveChest PainDepression
AnxietyAsthenia (weakness)Fatigue (feeling of tiredness)

Most common side effects experienced by people in long term use:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Estradiol (Watson Labs)Prometrium (Unimed Pharms)Prempro (Wyeth Pharms Inc)
Breast CancerBreast CancerBreast Cancer Female
Breast Cancer FemaleBreast Cancer FemaleBreast Cancer
Oestrogen Receptor Assay PositiveDepressionOestrogen Receptor Assay Positive
Progesterone Receptor Assay PositivePainProgesterone Receptor Assay Positive
Breast Cancer In SituMyocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)Breast Cancer Metastatic
DepressionAnxietyBreast Cancer In Situ
Hypertension (high blood pressure)Panic AttackCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
PainGastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)Pulmonary Embolism (blockage of the main artery of the lung)
Breast Mass (localized swelling that feels different from the surrounding breast tissue)Oestrogen Receptor Assay PositiveDepression
Headache (pain in head)Palpitations (feelings or sensations that your heart is pounding or racing)Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

Drug effectiveness:

not at allsomewhatmoderatehighvery high
Estradiol1.96%12.99%31.62%37.50%15.93%
Prometrium2.20%14.29%32.97%32.97%17.58%
Prempro3.90%6.49%20.78%48.05%20.78%

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Next: study your drugs OR ask a question from Patients Like You

Drug effectiveness in real world:

Alternative drugs:

Side effects in real world:

On eHealthMe, Estradiol (estradiol) is often used to treat hormone replacement therapy. Prometrium (progesterone) is often used to treat hormone replacement therapy. Prempro (estrogens, conjugated; medroxyprogesterone acetate) is often used to treat menopause. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug comparison:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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