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Hydrochlorothiazide vs Spironolactone, a side effect and effectiveness comparison for a male patient aged 51

This is personalized comparison of Hydrochlorothiazide vs Spironolactone for a male aged 51. The study is created by eHealthMe based on reports from FDA and social media.

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What are the drugs

Hydrochlorothiazide (latest outcomes from 61,870 users) has active ingredients of hydrochlorothiazide. It is often used in high blood pressure.

Spironolactone (latest outcomes from 26,368 users) has active ingredients of spironolactone. It is often used in acne.

On Jul, 10, 2014: 3,817 male patients aged 46 who take the same drugs are studied in Hydrochlorothiazide vs Spironolactone

Information of patient in study:

GenderAgeReason for the drug
Male46High blood pressure

Drugs to compare:

Hydrochlorothiazide hydrochlorothiazideVintage Pharms
Spironolactone spironolactoneActavis Elizabeth

eHealthMe real world results:

For males aged 46 (±5):

Most common side effects:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Hydrochlorothiazide (Vintage Pharms)Spironolactone (Actavis Elizabeth)
Fatigue (feeling of tiredness)Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)Oedema Peripheral (superficial swelling)
Asthenia (weakness)Hypotension (abnormally low blood pressure)
Chest PainNausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)Dyspnoea (difficult or laboured respiration)
DizzinessAscites (accumulation of fluid in the abdominal cavity)
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)Vomiting
DepressionWeight Increased
Oedema Peripheral (superficial swelling)Dizziness
PainRenal Failure Acute (rapid kidney dysfunction)

Most common side effects experienced by people in long term use:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Hydrochlorothiazide (Vintage Pharms)Spironolactone (Actavis Elizabeth)
Burning SensationNephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Edema - Peripheral, Peripheral Edema (severe swelling can cause permanent damage to nerves, resulting in peripheral neuropathy)Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney)
Lightheadedness - Dizzy (a common and often unpleasant sensation of dizziness)Renal Impairment (severely reduced kidney function)
Acid Reflux (stomach acids rise up)Blood Albumin Decreased
Burning Feet Syndrome (burning sensation in the sole of the foot)Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Gout (uric acid crystals building up in the body)Renal Failure Acute (rapid kidney dysfunction)
Sinus Congestion (blockage of sinus)Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal Failure Acute (rapid kidney dysfunction)Hepatorenal Syndrome (renal failure in patients with advanced chronic liver disease)
Myalgia (muscle pain)Depression
Muscle SwellingMetabolic Acidosis Nos (body produces too much acid, or when the kidneys are not removing enough acid from the body)

Drug effectiveness:

not at allsomewhatmoderatehighvery high

How to use the study:
1. print a copy of the study
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Drug effectiveness in real world:

Alternative drugs:

Side effects in real world:

On eHealthMe, Hydrochlorothiazide (hydrochlorothiazide) is often used to treat high blood pressure. Spironolactone (spironolactone) is often used to treat acne. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug comparison:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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