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Chlorpheniramine Maleate vs Diphenhydramine Hydrochloride, a side effect and effectiveness comparison for a male patient aged 50

This is personalized comparison of Chlorpheniramine Maleate vs Diphenhydramine Hydrochloride for a male aged 50. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Chlorpheniramine maleate (latest outcomes from 3,081 users) has active ingredients of chlorpheniramine maleate. It is often used in allergies.

Diphenhydramine hydrochloride (latest outcomes from 2,998 users) has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia.

On Oct, 13, 2014: 2,019 male patients aged 45 who take the same drugs are studied in Chlorpheniramine Maleate vs Diphenhydramine Hydrochloride

Information of patient in study:

GenderAgeReason for the drug

Drugs to compare:

Chlorpheniramine Maleate chlorpheniramine maleateRoxane
Diphenhydramine Hydrochloride diphenhydramine hydrochlorideAbraxis Pharm

eHealthMe real world results:

For males aged 45 (±5):

Most common side effects:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Chlorpheniramine Maleate (Roxane)Diphenhydramine Hydrochloride (Abraxis Pharm)
Blood Pressure IncreasedNausea (feeling of having an urge to vomit)
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)Pyrexia (fever)
Pyrexia (fever)Fatigue (feeling of tiredness)
Myocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)Pain
Headache Nos (pain in head)Vomiting
Dyspnoea (difficult or laboured respiration)Back Pain
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)Insomnia (sleeplessness)
Somnolence (a state of near-sleep, a strong desire for sleep)Chest Pain
Stomatitis (inflammation of mucous membrane of mouth)Anxiety

Most common side effects experienced by people in long term use:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Chlorpheniramine Maleate (Roxane)Diphenhydramine Hydrochloride (Abraxis Pharm)
Memory ImpairmentIron Deficiency Anemia
Headache (pain in head)Tardive Dyskinesia (a disorder that involves involuntary movements)
Oedema Peripheral (superficial swelling)Headache (pain in head)
Psychotic Disorder NosLigament Rupture (tear in ligament)
Urinary Tract Infection NosMeniscus Lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Subarachnoid Haemorrhage Nos (blood leaks into the space between two membranes that surround the brain)Haemorrhage (bleeding)
Dyspnoea (difficult or laboured respiration)Gingival Bleeding (bleeding gums)
Difficulty In WalkingDyspnoea (difficult or laboured respiration)
Body Temperature IncreasedEye Irritation
Blood Pressure IncreasedAnxiety

Drug effectiveness:

not at allsomewhatmoderatehighvery high
Chlorpheniramine Maleate0.00%60.00%40.00%0.00%0.00%
Diphenhydramine Hydrochloride6.90%35.63%32.18%19.54%5.75%

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Next: study your drugs OR ask a question from Patients Like You

Side effects in real world:

On eHealthMe, Chlorpheniramine Maleate (chlorpheniramine maleate) is often used to treat allergies. Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug comparison:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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