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Home > Health tools > Drug comparison > Diphenhydramine Hydrochloride vs Chlorpheniramine Maleate

Diphenhydramine Hydrochloride vs Chlorpheniramine Maleate, a side effect and effectiveness comparison for a male patient aged 24

This is personalized comparison of Diphenhydramine Hydrochloride vs Chlorpheniramine Maleate for a male aged 24. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Diphenhydramine hydrochloride (latest outcomes from 2,993 users) has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia.

Chlorpheniramine maleate (latest outcomes from 3,080 users) has active ingredients of chlorpheniramine maleate. It is often used in allergen.

On Nov, 15, 2014: 1,045 male patients aged 19 who take the same drugs are studied in Diphenhydramine Hydrochloride vs Chlorpheniramine Maleate

Information of patient in study:

GenderAgeReason for the drug
Male19allergic reaction sting

Drugs to compare:

Diphenhydramine Hydrochloride diphenhydramine hydrochloridePvt Form
Chlorpheniramine Maleate chlorpheniramine maleatenot specified

eHealthMe real world results:

For males aged 19 (±5):

Most common side effects:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Diphenhydramine Hydrochloride (Pvt Form)Chlorpheniramine Maleate
Pyrexia (fever)Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Nausea (feeling of having an urge to vomit)Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Completed Suicide (act of taking one's own life)Multiple Drug Overdose
Dyspnoea (difficult or laboured respiration)Pyrexia (fever)
Chest PainBlood Bilirubin Increased
Headache (pain in head)Alanine Aminotransferase Increased
Fatigue (feeling of tiredness)Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)
Drug ToxicityVomiting

Most common side effects experienced by people in long term use:

(click on each outcome to view in-depth analysis, incl. how people recovered)
Diphenhydramine Hydrochloride (Pvt Form)Chlorpheniramine Maleate
Ringing In The Ears (a ringing in the ears)
Rash Scaly
Drug Dependence
Loss Of Consciousness
Road Traffic Accident
Appendicitis (inflammation of the appendix)
Somnolence (a state of near-sleep, a strong desire for sleep)
Dry Skin

Drug effectiveness:

not at allsomewhatmoderatehighvery high
Diphenhydramine Hydrochloride5.63%15.49%29.58%36.62%12.68%
Chlorpheniramine Maleate0.00%33.33%66.67%0.00%0.00%

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Next: study your drugs OR ask a question from Patients Like You

Side effects in real world:

On eHealthMe, Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Chlorpheniramine Maleate (chlorpheniramine maleate) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug comparison:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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