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Phenergan vs Benadryl, a side effect and effectiveness comparison for a female patient aged 51

This is personalized comparison of Phenergan vs Benadryl for a female aged 51. The study is created by eHealthMe based on reports from FDA and social media.

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What are the drugs

Phenergan (latest outcomes from 13,012 users) has active ingredients of promethazine hydrochloride. It is often used in nausea.

Benadryl (latest outcomes from 29,317 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergen.

On May, 12, 2014: 4,858 female patients aged 47 who take the same drugs are studied in Phenergan vs Benadryl

Information of patient in study:

GenderAgeReason for the drug
Female47Nausea

Drugs to compare:

DrugIngredientsCompany
Phenergan promethazine hydrochloridenot specified
Benadryl diphenhydramine hydrochlorideMcneil Cons

eHealthMe real world results:

For females aged 47 (±5):

Most common side effects:

(click on each outcome to view in-depth analysis, incl. how people recovered)
PhenerganBenadryl (Mcneil Cons)
Nausea (feeling of having an urge to vomit)Nausea (feeling of having an urge to vomit)
VomitingDyspnoea (difficult or laboured respiration)
PainHeadache (pain in head)
Dyspnoea (difficult or laboured respiration)Fatigue (feeling of tiredness)
Chest PainPain
AnxietyPyrexia (fever)
Headache (pain in head)Chest Pain
Dehydration (dryness resulting from the removal of water)Pruritus (severe itching of the skin)
Back PainAnxiety
Abdominal PainVomiting

Most common side effects experienced by people in long term use:

(click on each outcome to view in-depth analysis, incl. how people recovered)
PhenerganBenadryl (Mcneil Cons)
Anxiety AggravatedArthritis (form of joint disorder that involves inflammation of one or more joints)
Heart Rate IncreasedPseudoporphyria (skin changes consistent with one of the porphyrias, but laboratory tests do not detect significant abnormalities)
Insomnia (sleeplessness)Herniated Intervertebral Disk
Nausea (feeling of having an urge to vomit)Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry)
VomitingDepression Suicidal (suicide depressive disorder)
Sweating Increased (excess sweating)Constipation
Fatigue (feeling of tiredness)Facial Nerve Disorder (disease of face nerve)
Nausea And VomitingAnxiety
Muscle Aches (muscle pain)Pelvic Discomfort
Tachycardia Irregular (irregular, uneven, or skipping beats with increased heart rate)Fatigue - Chronic (long feeling of tiredness)

Drug effectiveness:

not at allsomewhatmoderatehighvery high
Phenergan4.72%8.66%37.80%21.26%27.56%
Benadryl1.44%27.88%32.21%27.40%11.06%

How to use the study:
1. print a copy of the study
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2. start a mobile support group with people like you or your health teams to improve treatment outcomes together.

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Drug effectiveness in real world:

Alternative drugs:

Side effects in real world:

On eHealthMe, Phenergan (promethazine hydrochloride) is often used to treat nausea. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug comparison:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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