Review: taking Adderall and Topamax together


Summary

Drug interactions are reported among people who take Adderall and Topamax together. This review analyzes the effectiveness and drug interactions between Adderall and Topamax. It is created by eHealthMe based on reports of 587 people who take the same drugs from FDA and social media, and is updated regularly.

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Adderall

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Adderall 18,354 users)

Topamax

Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from Topamax 27,293 users)

On Aug, 21, 2016

587 people who take Adderall, Topamax are studied.


Number of reports submitted per year:

Adderall and Topamax drug interactions.

Drug effectiveness over time:

Adderall:
  • < 1 month: 0.0% - (0 of 10 people)
  • 1 - 6 months: 26.0% - (7 of 26 people)
  • 6 - 12 months: 42.0% - (6 of 14 people)
  • 1 - 2 years: 60.0% - (20 of 33 people)
  • 2 - 5 years: 64.0% - (20 of 31 people)
  • 5 - 10 years: 66.0% - (14 of 21 people)
  • 10+ years: 75.0% - (3 of 4 people)
  • not specified: 50.0% - (3 of 6 people)
Topamax:
  • < 1 month: 28.0% - (2 of 7 people)
  • 1 - 6 months: 34.0% - (8 of 23 people)
  • 6 - 12 months: 7.0% - (1 of 13 people)
  • 1 - 2 years: 37.0% - (10 of 27 people)
  • 2 - 5 years: 45.0% - (14 of 31 people)
  • 5 - 10 years: 60.0% - (14 of 23 people)
  • 10+ years: 80.0% - (8 of 10 people)
  • not specified: 0.0% - (0 of 6 people)

Drug effectiveness by gender:

Adderall:
  • female: 50.0% - (69 of 137 people)
  • male: 50.0% - (4 of 8 people)
Topamax:
  • female: 42.0% - (56 of 133 people)
  • male: 14.0% - (1 of 7 people)

Drug effectiveness by age:

Adderall:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 1 people)
  • 10-19: 12.0% - (1 of 8 people)
  • 20-29: 63.0% - (21 of 33 people)
  • 30-39: 46.0% - (24 of 52 people)
  • 40-49: 51.0% - (21 of 41 people)
  • 50-59: 75.0% - (6 of 8 people)
  • 60+: 0.0% - (0 of 2 people)
Topamax:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 1 people)
  • 10-19: 22.0% - (2 of 9 people)
  • 20-29: 48.0% - (15 of 31 people)
  • 30-39: 25.0% - (12 of 48 people)
  • 40-49: 58.0% - (24 of 41 people)
  • 50-59: 37.0% - (3 of 8 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • weight decreased
  • dry mouth
  • headache
  • hyperammonaemia
  • rash
  • ringing in the ears
  • appetite - decreased
  • depression
  • diarrhea
1 - 6 months:
  • seborrhoeic dermatitis
  • dizziness
  • body height increased
  • chest pain
  • headaches
  • sleepy
  • weight increased
  • acid reflux
  • agitation
  • alopecia
6 - 12 months:
  • edema
  • rash
  • irritability
  • itching
  • lethargy
  • mood swings
  • skin sensitisation
  • abdominal pain
  • air swallowing
  • alopecia
1 - 2 years:
  • facial palsy
  • loss of hair
  • fatigue
  • dizziness
  • headache
  • insomnia
  • dry mouth
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • nausea
  • weight gain
2 - 5 years:
  • depression
  • facial palsy
  • migraine
  • anorgasmia
  • asthma
  • fatigue
  • headache
  • narcolepsy
  • nausea
  • dizziness
5 - 10 years:
  • migraine
  • depression
  • anxiety and stress
  • asthma
  • bipolar 2
  • bipolar ii disorder
  • hyperhidrosis
  • loss of employment
  • multiple sclerosis
  • narcolepsy
10+ years:
  • seborrhoeic dermatitis
  • dizziness
  • abdominal pain
  • fatigue
  • headache
  • irritability
  • itching
  • mood changes
  • night sweats
  • vision blurred
not specified:
  • fatigue
  • pain
  • depression
  • drug ineffective
  • nausea
  • anxiety
  • dyspnoea
  • headache
  • chest pain
  • oedema peripheral

Most common drug interactions by gender *:

female:
  • fatigue
  • pain
  • nausea
  • depression
  • headache
  • drug ineffective
  • migraine
  • anxiety
  • dizziness
  • dyspnoea
male:
  • dehydration
  • depression
  • diarrhoea
  • gastritis erosive
  • haemorrhoidal haemorrhage
  • pulmonary embolism
  • colitis
  • diabetes mellitus
  • dizziness
  • hypovolaemia

Most common drug interactions by age *:

0-1:
  • anaphylactoid reaction
  • choking sensation
  • drug hypersensitivity
  • dysgeusia
  • dyspnoea
  • fatigue
  • headache
  • heart rate increased
  • hypersensitivity
  • musculoskeletal stiffness
2-9:
  • tic
  • attention deficit/hyperactivity disorder
  • emotional disorder
  • weight decreased
  • antisocial behaviour
  • autism spectrum disorder
  • bipolar disorder
  • congenital central nervous system anomaly
  • decreased activity
  • diarrhoea
10-19:
  • anxiety
  • facial palsy
  • diabetes mellitus
  • diabetic ketoacidosis
  • pain
  • obesity
  • type 1 diabetes mellitus
  • general physical health deterioration
  • cholecystitis chronic
  • fatigue
20-29:
  • sedation
  • cognitive disorder
  • fatigue
  • sexual dysfunction
  • granulocytopenia
  • psychotic disorder
  • aggression
  • dizziness
  • feeling abnormal
  • nausea
30-39:
  • seborrhoeic dermatitis
  • nausea
  • dyspnoea
  • headache
  • migraine
  • pain
  • depression
  • fatigue
  • abdominal pain upper
  • pulmonary embolism
40-49:
  • fatigue
  • depression
  • pain
  • headache
  • migraine
  • dehydration
  • multiple sclerosis relapse
  • dizziness
  • drug ineffective
  • nausea
50-59:
  • dizziness
  • asthenia
  • dyspnoea
  • somnolence
  • anxiety
  • pain
  • fatigue
  • hypokalaemia
  • tremor
  • confusional state
60+:
  • oedema peripheral
  • pain in extremity
  • progressive multifocal leukoencephalopathy
  • altered state of consciousness
  • ankle fracture
  • blood pressure decreased
  • contusion
  • crying
  • deep vein thrombosis
  • depression

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) is often used to treat attention deficit hyperactivity disorder. Topamax (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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