Review: taking Aleve and Xarelto together


Summary

Drug interactions are reported among people who take Aleve and Xarelto together. This review analyzes the effectiveness and drug interactions between Aleve and Xarelto. It is created by eHealthMe based on reports of 81 people who take the same drugs from FDA and social media, and is updated regularly.

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Aleve

Aleve has active ingredients of naproxen sodium. It is often used in arthritis. (latest outcomes from Aleve 25,188 users)

Xarelto

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from Xarelto 14,768 users)

On Aug, 25, 2016

81 people who take Aleve, Xarelto are studied.


Number of reports submitted per year:

Aleve and Xarelto drug interactions.

Most common drug interactions over time *:

< 1 month:
  • gastric ulcer
  • melaena
  • dizziness
  • gastrointestinal haemorrhage
  • thrombocytosis
  • duodenal ulcer
  • rectal haemorrhage
  • pulmonary embolism
  • phlebitis
  • tachycardia
1 - 6 months:
  • cardiac tamponade
  • thrombocytopenia
  • asthenia
  • atrial flutter
  • confusional state
  • faeces discoloured
  • haemoglobin decreased
  • post procedural haemorrhage
  • atrial fibrillation
  • gastrointestinal haemorrhage
6 - 12 months:
  • adverse drug reaction
  • blood urine present
  • urinary tract infection
  • hyponatraemia
  • pancytopenia
1 - 2 years:
  • in-stent coronary artery restenosis
not specified:
  • gastrointestinal haemorrhage
  • dizziness
  • haemoglobin decreased
  • nephrolithiasis
  • international normalised ratio increased
  • thrombosis
  • blood urine present
  • gastric ulcer
  • melaena
  • duodenal ulcer

Most common drug interactions by gender *:

female:
  • gastric ulcer
  • gastrointestinal haemorrhage
  • international normalised ratio increased
  • haemoglobin decreased
  • melaena
  • thrombocytosis
  • upper gastrointestinal haemorrhage
  • hepatic enzyme increased
  • nausea
  • pulmonary embolism
male:
  • dizziness
  • gastrointestinal haemorrhage
  • duodenal ulcer
  • haemoglobin decreased
  • melaena
  • blood urine present
  • post procedural haemorrhage
  • thrombosis
  • gastric ulcer
  • duodenal ulcer haemorrhage

Most common drug interactions by age *:

10-19:
  • thrombosis
  • dizziness
  • phlebitis
  • tachycardia
30-39:
  • adrenal insufficiency
  • arthritis
  • asthma
  • bronchitis
  • cushingoid
  • h1n1 influenza
  • migraine
  • nephrolithiasis
  • oedema
  • pneumonia
40-49:
  • in-stent coronary artery restenosis
50-59:
  • blood urine present
  • nephrolithiasis
  • duodenal ulcer haemorrhage
  • infection
  • cardiac arrest
  • pulmonary embolism
  • bronchospasm
  • cough
  • dyspnoea
  • international normalised ratio decreased
60+:
  • gastric ulcer
  • haemoglobin decreased
  • melaena
  • dizziness
  • duodenal ulcer
  • international normalised ratio increased
  • rectal haemorrhage
  • atrial fibrillation
  • nausea
  • gastrointestinal haemorrhage

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Aleve (naproxen sodium) is often used to treat arthritis. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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