Review: taking Aleve and Xarelto together


Summary

Drug interactions are reported among people who take Aleve and Xarelto together. This review analyzes the effectiveness and drug interactions between Aleve and Xarelto. It is created by eHealthMe based on reports of 376 people who take the same drugs from FDA and social media, and is updated regularly.

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Aleve

Aleve has active ingredients of naproxen sodium. It is often used in arthritis. (latest outcomes from Aleve 37,838 users)

Xarelto

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from Xarelto 53,959 users)

On Sep, 16, 2016

376 people who take Aleve, Xarelto are studied.


Number of reports submitted per year:

Aleve and Xarelto drug interactions.

Most common drug interactions over time *:

< 1 month:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • rectal haemorrhage
  • gastric ulcer
  • anaemia
  • melaena
  • dizziness
  • blood creatinine increased
  • blood electrolytes abnormal
  • duodenal ulcer
1 - 6 months:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • atrial fibrillation
  • haemorrhagic anaemia
  • nausea
  • rectal haemorrhage
  • anaemia
  • orthostatic hypotension
  • vaginal haemorrhage
  • duodenal ulcer haemorrhage
6 - 12 months:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • haematuria
  • arterial haemorrhage
  • cold sweat
  • haemorrhagic anaemia
  • hypotension
  • influenza
1 - 2 years:
  • rectal haemorrhage
  • upper gastrointestinal haemorrhage
  • colitis ischaemic
  • diverticulum
  • duodenal ulcer haemorrhage
  • haematoma
  • renal failure
  • shock haemorrhagic
  • gastrointestinal haemorrhage
  • anaemia
2 - 5 years:
  • acute respiratory failure
  • hepatic haemorrhage
  • peritoneal haemorrhage
  • anaemia
  • haematemesis
  • upper gastrointestinal haemorrhage
5 - 10 years:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
not specified:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • atrial fibrillation
  • dizziness
  • dyspnoea
  • haemorrhage
  • duodenal ulcer haemorrhage
  • nausea

Most common drug interactions by gender *:

female:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • nausea
  • upper gastrointestinal haemorrhage
  • atrial fibrillation
  • anaemia
  • loss of consciousness
  • duodenal ulcer haemorrhage
  • small intestinal haemorrhage
  • gastric ulcer
male:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • anaemia
  • rectal haemorrhage
  • dizziness
  • duodenal ulcer
  • duodenal ulcer haemorrhage
  • post procedural haemorrhage
  • atrial fibrillation
  • haematuria

Most common drug interactions by age *:

10-19:
  • thrombosis
  • dizziness
  • phlebitis
  • tachycardia
20-29:
  • delirium
  • dizziness
  • dyspnoea
  • malaise
  • nausea
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • cerebral infarction
  • post procedural complication
30-39:
  • haemoptysis
  • abdominal pain upper
  • cerebrovascular accident
  • chest pain
  • deep vein thrombosis
  • dehydration
  • drug ineffective
  • dyspnoea
  • gastrooesophageal reflux disease
  • hypertensive emergency
40-49:
  • haematoma
  • vascular pseudoaneurysm
  • anaemia
  • haematemesis
  • vaginal haemorrhage
  • activated partial thromboplastin time prolonged
  • intentional overdose
  • international normalised ratio increased
  • gastrointestinal haemorrhage
  • menorrhagia
50-59:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • mallory-weiss syndrome
  • upper gastrointestinal haemorrhage
  • haemorrhagic anaemia
  • hepatitis acute
  • pulmonary embolism
  • blood urine present
  • nephrolithiasis
  • post procedural complication
60+:
  • gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • duodenal ulcer haemorrhage
  • atrial fibrillation
  • nausea
  • gastric ulcer
  • dizziness
  • duodenal ulcer

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Aleve (naproxen sodium) is often used to treat arthritis. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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