Review: taking Ambien and Benadryl together


Summary

Drug interactions are reported among people who take Ambien and Benadryl together. This review analyzes the effectiveness and drug interactions between Ambien and Benadryl. It is created by eHealthMe based on reports of 2,761 people who take the same drugs from FDA and social media, and is updated regularly.

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Ambien

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. (latest outcomes from Ambien 51,333 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)

On Aug, 18, 2016

2,761 people who take Ambien, Benadryl are studied.


Number of reports submitted per year:

Ambien and Benadryl drug interactions.

Drug effectiveness over time:

Ambien:
  • < 1 month: 38.0% - (7 of 18 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 50.0% - (8 of 16 people)
  • 1 - 2 years: 26.0% - (4 of 15 people)
  • 2 - 5 years: 52.0% - (12 of 23 people)
  • 5 - 10 years: 71.0% - (5 of 7 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)
Benadryl:
  • < 1 month: 31.0% - (5 of 16 people)
  • 1 - 6 months: 30.0% - (4 of 13 people)
  • 6 - 12 months: 50.0% - (3 of 6 people)
  • 1 - 2 years: 30.0% - (3 of 10 people)
  • 2 - 5 years: 42.0% - (6 of 14 people)
  • 5 - 10 years: 8.0% - (1 of 12 people)
  • 10+ years: 40.0% - (4 of 10 people)
  • not specified: 50.0% - (2 of 4 people)

Drug effectiveness by gender:

Ambien:
  • female: 44.0% - (30 of 68 people)
  • male: 47.0% - (10 of 21 people)
Benadryl:
  • female: 33.0% - (21 of 63 people)
  • male: 31.0% - (7 of 22 people)

Drug effectiveness by age:

Ambien:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (3 of 6 people)
  • 20-29: 27.0% - (3 of 11 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 53.0% - (14 of 26 people)
  • 50-59: 40.0% - (9 of 22 people)
  • 60+: 55.0% - (5 of 9 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 16.0% - (1 of 6 people)
  • 20-29: 36.0% - (4 of 11 people)
  • 30-39: 31.0% - (5 of 16 people)
  • 40-49: 37.0% - (9 of 24 people)
  • 50-59: 42.0% - (8 of 19 people)
  • 60+: 11.0% - (1 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • pneumothorax
  • hypotension
  • dyspnoea
  • febrile neutropenia
  • anaemia
  • dehydration
  • sepsis
  • atrial fibrillation
  • pain in extremity
1 - 6 months:
  • headache
  • skin burning sensation
  • diarrhea
  • rhinorrhoea
  • small intestinal obstruction
  • stevens-johnson syndrome
  • chest tightness
  • constipation
  • diaphoresis
  • flushing
6 - 12 months:
  • atrial septal defect
  • dizziness
  • amnesia
  • anger
  • asthenia
  • ataxia
  • bradyarrhythmia
  • confusional state
  • dehydration
  • depression
1 - 2 years:
  • anger
  • pain exacerbated
  • stress
  • dizziness
  • anaphylaxis treatment
  • atrial septal defect
  • congenital mitral valve incompetence
  • hair loss
  • headache
  • jaundice neonatal
2 - 5 years:
  • depression
  • headache
  • heart pounding or racing
  • insomnia
  • palpitations
  • balance disorder
  • dysarthria
  • impaired driving ability
  • lacrimation increased
  • ocular hyperaemia
5 - 10 years:
  • pain
  • oedema peripheral
  • amnesia
  • arthralgia
  • eating disorder
  • somnambulism
  • anger
  • anxiety
  • chest pain
  • deep vein thrombosis
10+ years:
  • fatigue
  • nausea and vomiting
  • abdominal pain upper
  • amnesia
  • anxiety
  • bone loss
  • depression
  • dermatitis acneiform
  • drug dependence
  • hot flashes
not specified:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • arthralgia
  • back pain
  • headache
  • vomiting
  • anaemia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • headache
  • arthralgia
  • osteonecrosis of jaw
  • anaemia
  • insomnia
male:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • back pain
  • depression
  • asthenia
  • fatigue
  • arthralgia
  • pyrexia

Most common drug interactions by age *:

0-1:
  • cardiac arrest
  • respiratory arrest
  • convulsion
  • poisoning
  • aggression
  • drug toxicity
  • orthostatic hypotension
  • agitation
  • foaming at mouth
  • tardive dyskinesia
2-9:
  • fungal test positive
  • hypokalaemia
  • transfusion reaction
  • bronchiectasis
  • culture positive
  • diarrhoea
  • rash
  • respiratory tract infection fungal
  • restrictive pulmonary disease
  • stem cell transplant
10-19:
  • agitation
  • weight increased
  • convulsion
  • drug abuse
  • musculoskeletal stiffness
  • pyrexia
  • suicidal ideation
  • pneumonia
  • blood potassium decreased
  • headache
20-29:
  • insomnia
  • nausea
  • back pain
  • vomiting
  • pain
  • anxiety
  • urinary tract infection
  • influenza like illness
  • headache
  • asthenia
30-39:
  • pain
  • pyrexia
  • dyspnoea
  • depression
  • headache
  • abdominal pain
  • fatigue
  • insomnia
  • anxiety
  • nausea
40-49:
  • pain
  • back pain
  • nausea
  • anxiety
  • headache
  • arthralgia
  • pain in extremity
  • fall
  • chest pain
  • depression
50-59:
  • anxiety
  • pain
  • dyspnoea
  • nausea
  • injury
  • pyrexia
  • insomnia
  • osteonecrosis of jaw
  • arthralgia
  • headache
60+:
  • anxiety
  • fall
  • dyspnoea
  • fatigue
  • anaemia
  • back pain
  • pain
  • nausea
  • arthralgia
  • osteonecrosis of jaw

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ambien (zolpidem tartrate) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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