Review: taking Ambien and Benadryl together


Summary

Drug interactions are reported among people who take Ambien and Benadryl together. This review analyzes the effectiveness and drug interactions between Ambien and Benadryl. It is created by eHealthMe based on reports of 3,852 people who take the same drugs from FDA and social media, and is updated regularly.

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Ambien

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. (latest outcomes from Ambien 62,490 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 18, 2016

3,852 people who take Ambien, Benadryl are studied.


Number of reports submitted per year:

Ambien and Benadryl drug interactions.

Drug effectiveness over time:

Ambien:
  • < 1 month: 38.0% - (7 of 18 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 50.0% - (8 of 16 people)
  • 1 - 2 years: 26.0% - (4 of 15 people)
  • 2 - 5 years: 52.0% - (12 of 23 people)
  • 5 - 10 years: 71.0% - (5 of 7 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)
Benadryl:
  • < 1 month: 31.0% - (5 of 16 people)
  • 1 - 6 months: 30.0% - (4 of 13 people)
  • 6 - 12 months: 50.0% - (3 of 6 people)
  • 1 - 2 years: 30.0% - (3 of 10 people)
  • 2 - 5 years: 42.0% - (6 of 14 people)
  • 5 - 10 years: 8.0% - (1 of 12 people)
  • 10+ years: 40.0% - (4 of 10 people)
  • not specified: 50.0% - (2 of 4 people)

Drug effectiveness by gender:

Ambien:
  • female: 44.0% - (30 of 68 people)
  • male: 47.0% - (10 of 21 people)
Benadryl:
  • female: 33.0% - (21 of 63 people)
  • male: 31.0% - (7 of 22 people)

Drug effectiveness by age:

Ambien:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (3 of 6 people)
  • 20-29: 27.0% - (3 of 11 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 53.0% - (14 of 26 people)
  • 50-59: 40.0% - (9 of 22 people)
  • 60+: 55.0% - (5 of 9 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 16.0% - (1 of 6 people)
  • 20-29: 36.0% - (4 of 11 people)
  • 30-39: 31.0% - (5 of 16 people)
  • 40-49: 37.0% - (9 of 24 people)
  • 50-59: 42.0% - (8 of 19 people)
  • 60+: 11.0% - (1 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • hypotension
  • pneumothorax
  • anaemia
  • febrile neutropenia
  • dehydration
  • skin ulcer
  • atrial tachycardia
  • dyspnoea
  • pain
1 - 6 months:
  • death
  • stevens-johnson syndrome
  • headache
  • intestinal perforation
  • nausea
  • bacteraemia
  • insomnia
  • pyrexia
  • skin burning sensation
  • diarrhea
6 - 12 months:
  • atrial septal defect
  • dizziness
  • dehydration
  • gait disturbance
  • amnesia
  • anger
  • asthenia
  • ataxia
  • bradyarrhythmia
  • confusional state
1 - 2 years:
  • dizziness
  • hyponatraemia
  • nausea
  • vomiting
  • anger
  • pain exacerbated
  • stress
  • atelectasis
  • headache
  • nephrogenic systemic fibrosis
2 - 5 years:
  • depression
  • headache
  • heart pounding or racing
  • insomnia
  • palpitations
  • balance disorder
  • dysarthria
  • impaired driving ability
  • lacrimation increased
  • ocular hyperaemia
5 - 10 years:
  • pain
  • contusion
  • fall
  • oedema peripheral
  • amnesia
  • arthralgia
  • eating disorder
  • somnambulism
  • somnolence
  • anger
10+ years:
  • depression
  • fatigue
  • nausea and vomiting
  • road traffic accident
  • abdominal pain upper
  • amnesia
  • anxiety
  • bone loss
  • cellulitis
  • dermatitis acneiform
not specified:
  • pain
  • nausea
  • anxiety
  • dyspnoea
  • fatigue
  • vomiting
  • arthralgia
  • headache
  • back pain
  • pyrexia

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • anxiety
  • dyspnoea
  • fatigue
  • headache
  • arthralgia
  • vomiting
  • insomnia
  • pyrexia
male:
  • pain
  • nausea
  • fatigue
  • dyspnoea
  • anxiety
  • asthenia
  • back pain
  • pyrexia
  • vomiting
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • cardiac arrest
  • respiratory arrest
  • convulsion
  • poisoning
  • aggression
  • drug toxicity
  • orthostatic hypotension
  • agitation
  • foaming at mouth
  • tardive dyskinesia
2-9:
  • fungal test positive
  • hypokalaemia
  • transfusion reaction
  • bronchiectasis
  • culture positive
  • diarrhoea
  • rash
  • respiratory tract infection fungal
  • restrictive pulmonary disease
  • stem cell transplant
10-19:
  • agitation
  • weight increased
  • convulsion
  • drug abuse
  • headache
  • musculoskeletal stiffness
  • pyrexia
  • suicidal ideation
  • pneumonia
  • vomiting
20-29:
  • insomnia
  • nausea
  • pain
  • anxiety
  • vomiting
  • back pain
  • influenza like illness
  • urinary tract infection
  • headache
  • completed suicide
30-39:
  • pain
  • pyrexia
  • dyspnoea
  • headache
  • nausea
  • abdominal pain
  • completed suicide
  • depression
  • fatigue
  • insomnia
40-49:
  • pain
  • back pain
  • nausea
  • anxiety
  • arthralgia
  • headache
  • pain in extremity
  • diarrhoea
  • fall
  • fatigue
50-59:
  • anxiety
  • pain
  • dyspnoea
  • nausea
  • injury
  • pyrexia
  • arthralgia
  • insomnia
  • headache
  • fatigue
60+:
  • fatigue
  • nausea
  • dyspnoea
  • anxiety
  • fall
  • asthenia
  • pain
  • anaemia
  • back pain
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Ambien (zolpidem tartrate) is often used to treat insomnia. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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