Review: taking Amitriptyline hydrochloride and Cymbalta together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Cymbalta together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Cymbalta. It is created by eHealthMe based on reports of 1,823 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,238 users)

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 56,552 users)

On Aug, 21, 2016

1,823 people who take Amitriptyline Hydrochloride, Cymbalta are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Cymbalta drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 45.0% - (5 of 11 people)
  • 1 - 6 months: 12.0% - (2 of 16 people)
  • 6 - 12 months: 11.0% - (2 of 17 people)
  • 1 - 2 years: 22.0% - (5 of 22 people)
  • 2 - 5 years: 45.0% - (10 of 22 people)
  • 5 - 10 years: 36.0% - (4 of 11 people)
  • 10+ years: 80.0% - (12 of 15 people)
  • not specified: 0.0% - (0 of 1 people)
Cymbalta:
  • < 1 month: 0.0% - (0 of 9 people)
  • 1 - 6 months: 20.0% - (5 of 25 people)
  • 6 - 12 months: 15.0% - (3 of 20 people)
  • 1 - 2 years: 25.0% - (5 of 20 people)
  • 2 - 5 years: 24.0% - (6 of 25 people)
  • 5 - 10 years: 41.0% - (5 of 12 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 35.0% - (32 of 90 people)
  • male: 32.0% - (8 of 25 people)
Cymbalta:
  • female: 23.0% - (21 of 89 people)
  • male: 20.0% - (5 of 25 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 23.0% - (3 of 13 people)
  • 30-39: 37.0% - (9 of 24 people)
  • 40-49: 33.0% - (10 of 30 people)
  • 50-59: 52.0% - (13 of 25 people)
  • 60+: 21.0% - (5 of 23 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 15.0% - (2 of 13 people)
  • 30-39: 29.0% - (8 of 27 people)
  • 40-49: 13.0% - (4 of 30 people)
  • 50-59: 31.0% - (7 of 22 people)
  • 60+: 22.0% - (5 of 22 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • fall
  • pain
  • abdominal pain upper
  • dyspnoea
  • anxiety
  • constipation
  • cough
  • hypertension
  • hypophagia
1 - 6 months:
  • dizziness
  • fall
  • loss of consciousness
  • drug ineffective
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • headache
  • renal failure
  • blood alkaline phosphatase increased
  • injury
6 - 12 months:
  • confusional state
  • serotonin syndrome
  • anxiety
  • dyskinesia
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • nystagmus
  • weight bearing difficulty
  • back pain
  • depression
  • fibromyalgia
1 - 2 years:
  • fatigue
  • insomnia
  • constipation
  • diarrhea
  • muscle twitching
  • diarrhoea
  • fibromyalgia
  • pain
  • vomiting
  • acute respiratory failure
2 - 5 years:
  • pain
  • sleep walking
  • constipation
  • lung disorder
  • drug ineffective
  • rheumatoid arthritis
  • tremor
  • type 2 diabetes mellitus
  • agitation
  • asthenia
5 - 10 years:
  • depression
  • acid reflux
  • back pain
  • serotonin syndrome
  • sleep walking
  • bone and joint pain
  • candidiasis
  • death
  • dry mouth
  • eye pain
10+ years:
  • constipation
  • burning feet syndrome
  • migraine
  • nausea
  • abnormal behaviour
  • aggression
  • anxiety
  • anxiety aggravated
  • chills
  • chronic tonsillar disease
not specified:
  • pain
  • fall
  • nausea
  • anxiety
  • insomnia
  • fatigue
  • headache
  • arthralgia
  • pyrexia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • fall
  • nausea
  • anxiety
  • insomnia
  • headache
  • arthralgia
  • diarrhoea
  • dizziness
  • pyrexia
male:
  • pain
  • fatigue
  • pneumonia
  • nausea
  • asthenia
  • fall
  • anxiety
  • drug ineffective
  • chest pain
  • depression

Most common drug interactions by age *:

0-1:
  • blood cholesterol increased
  • gallbladder operation
  • sensation of foreign body
  • type 2 diabetes mellitus
2-9:
  • abasia
  • arthralgia
  • bursitis
  • diabetic coma
  • femur fracture
  • pain in extremity
  • pancreatitis
  • stress fracture
  • type 2 diabetes mellitus
  • agitation
10-19:
  • anxiety
  • depression
  • dizziness
  • fatigue
  • hypotension
  • insomnia
  • localised infection
  • mental disorder
  • somnolence
  • urinary tract infection
20-29:
  • pain
  • fatigue
  • anxiety
  • abdominal pain
  • insomnia
  • nausea
  • gait disturbance
  • muscle spasms
  • somnolence
  • depression
30-39:
  • death
  • dizziness
  • weight increased
  • depression
  • loss of consciousness
  • abdominal pain
  • agitation
  • type 2 diabetes mellitus
  • nausea
  • somnolence
40-49:
  • pain
  • nausea
  • fall
  • type 2 diabetes mellitus
  • abdominal pain upper
  • diarrhoea
  • fatigue
  • anxiety
  • back pain
  • feeling abnormal
50-59:
  • pain
  • nausea
  • fall
  • anxiety
  • pyrexia
  • arthralgia
  • diarrhoea
  • injury
  • insomnia
  • bone disorder
60+:
  • pain
  • headache
  • asthenia
  • fatigue
  • fall
  • pneumonia
  • weight decreased
  • anaemia
  • osteonecrosis of jaw
  • oedema peripheral

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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