Review: taking Amitriptyline hydrochloride and Cymbalta together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Cymbalta together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Cymbalta. It is created by eHealthMe based on reports of 2,598 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 8,334 users)

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 89,411 users)

On Sep, 18, 2016

2,598 people who take Amitriptyline Hydrochloride, Cymbalta are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Cymbalta drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 45.0% - (5 of 11 people)
  • 1 - 6 months: 12.0% - (2 of 16 people)
  • 6 - 12 months: 11.0% - (2 of 17 people)
  • 1 - 2 years: 22.0% - (5 of 22 people)
  • 2 - 5 years: 45.0% - (10 of 22 people)
  • 5 - 10 years: 36.0% - (4 of 11 people)
  • 10+ years: 80.0% - (12 of 15 people)
  • not specified: 0.0% - (0 of 1 people)
Cymbalta:
  • < 1 month: 0.0% - (0 of 9 people)
  • 1 - 6 months: 20.0% - (5 of 25 people)
  • 6 - 12 months: 15.0% - (3 of 20 people)
  • 1 - 2 years: 25.0% - (5 of 20 people)
  • 2 - 5 years: 24.0% - (6 of 25 people)
  • 5 - 10 years: 41.0% - (5 of 12 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 35.0% - (32 of 90 people)
  • male: 32.0% - (8 of 25 people)
Cymbalta:
  • female: 23.0% - (21 of 89 people)
  • male: 20.0% - (5 of 25 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 23.0% - (3 of 13 people)
  • 30-39: 37.0% - (9 of 24 people)
  • 40-49: 33.0% - (10 of 30 people)
  • 50-59: 52.0% - (13 of 25 people)
  • 60+: 21.0% - (5 of 23 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 15.0% - (2 of 13 people)
  • 30-39: 29.0% - (8 of 27 people)
  • 40-49: 13.0% - (4 of 30 people)
  • 50-59: 31.0% - (7 of 22 people)
  • 60+: 22.0% - (5 of 22 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • fall
  • pain
  • abdominal pain upper
  • constipation
  • diarrhoea
  • dyspnoea
  • hypertension
  • renal failure
  • anxiety
1 - 6 months:
  • dizziness
  • drug ineffective
  • fall
  • headache
  • loss of consciousness
  • renal failure
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • injury
  • blood alkaline phosphatase increased
6 - 12 months:
  • confusional state
  • nystagmus
  • serotonin syndrome
  • anxiety
  • depression
  • dyskinesia
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • weight bearing difficulty
  • back pain
  • dry mouth
1 - 2 years:
  • hyperhidrosis
  • feeling hot
  • insomnia
  • dizziness
  • anxiety
  • drug withdrawal syndrome
  • fatigue
  • weight increased
  • constipation
  • depression
2 - 5 years:
  • pain
  • sleep walking
  • constipation
  • lung disorder
  • tremor
  • weight increased
  • drug ineffective
  • nausea
  • rheumatoid arthritis
  • type 2 diabetes mellitus
5 - 10 years:
  • depression
  • acid reflux
  • back pain
  • serotonin syndrome
  • sleep walking
  • anxiety
  • bone and joint pain
  • candidiasis
  • death
  • dizziness
10+ years:
  • constipation
  • nausea
  • anxiety
  • burning feet syndrome
  • depression
  • dry mouth
  • fluid retention
  • migraine
  • abdominal discomfort
  • abnormal behaviour
not specified:
  • pain
  • fall
  • nausea
  • anxiety
  • insomnia
  • headache
  • fatigue
  • arthralgia
  • drug ineffective
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • fall
  • nausea
  • anxiety
  • insomnia
  • headache
  • arthralgia
  • dizziness
  • diarrhoea
  • fatigue
male:
  • pain
  • fatigue
  • drug ineffective
  • nausea
  • asthenia
  • anxiety
  • fall
  • chest pain
  • depression
  • headache

Most common drug interactions by age *:

0-1:
  • abdominal pain upper
  • aggression
  • attention deficit/hyperactivity disorder
  • blood cholesterol increased
  • foetal exposure during pregnancy
  • gallbladder operation
  • grunting
  • hyperaesthesia
  • irritability
  • oppositional defiant disorder
2-9:
  • abasia
  • arthralgia
  • bursitis
  • diabetic coma
  • femur fracture
  • pain in extremity
  • pancreatitis
  • stress fracture
  • type 2 diabetes mellitus
  • agitation
10-19:
  • depression
  • anxiety
  • nausea
  • vomiting
  • dizziness
  • fatigue
  • hypotension
  • insomnia
  • localised infection
  • mental disorder
20-29:
  • pain
  • fatigue
  • anxiety
  • insomnia
  • nausea
  • somnolence
  • abdominal pain
  • gait disturbance
  • agitation
  • diarrhoea
30-39:
  • weight increased
  • dizziness
  • agitation
  • loss of consciousness
  • depression
  • pain
  • abdominal pain
  • nausea
  • death
  • anxiety
40-49:
  • pain
  • nausea
  • fatigue
  • fall
  • anxiety
  • diarrhoea
  • drug ineffective
  • headache
  • back pain
  • abdominal pain upper
50-59:
  • pain
  • fall
  • nausea
  • anxiety
  • arthralgia
  • pyrexia
  • insomnia
  • diarrhoea
  • injury
  • bone disorder
60+:
  • pain
  • headache
  • asthenia
  • fall
  • fatigue
  • pneumonia
  • weight decreased
  • nausea
  • anaemia
  • malaise

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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