Review: taking Amitriptyline hydrochloride and Lorazepam together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Lorazepam together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Lorazepam. It is created by eHealthMe based on reports of 3,482 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 8,334 users)

Lorazepam

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. (latest outcomes from Lorazepam 67,727 users)

On Sep, 17, 2016

3,482 people who take Amitriptyline Hydrochloride, Lorazepam are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Lorazepam drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 8.0% - (1 of 12 people)
  • 6 - 12 months: 50.0% - (4 of 8 people)
  • 1 - 2 years: 36.0% - (4 of 11 people)
  • 2 - 5 years: 40.0% - (6 of 15 people)
  • 5 - 10 years: 36.0% - (4 of 11 people)
  • 10+ years: 50.0% - (3 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Lorazepam:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 11.0% - (1 of 9 people)
  • 6 - 12 months: 33.0% - (3 of 9 people)
  • 1 - 2 years: 54.0% - (6 of 11 people)
  • 2 - 5 years: 47.0% - (9 of 19 people)
  • 5 - 10 years: 70.0% - (7 of 10 people)
  • 10+ years: 40.0% - (4 of 10 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 33.0% - (17 of 51 people)
  • male: 30.0% - (6 of 20 people)
Lorazepam:
  • female: 44.0% - (24 of 54 people)
  • male: 31.0% - (7 of 22 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 13.0% - (2 of 15 people)
  • 50-59: 34.0% - (8 of 23 people)
  • 60+: 28.0% - (4 of 14 people)
Lorazepam:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (2 of 6 people)
  • 30-39: 53.0% - (8 of 15 people)
  • 40-49: 37.0% - (6 of 16 people)
  • 50-59: 41.0% - (10 of 24 people)
  • 60+: 33.0% - (5 of 15 people)

Most common drug interactions over time *:

< 1 month:
  • restless legs syndrome
  • chronic obstructive pulmonary disease
  • syncope
  • loss of consciousness
  • cardiac failure congestive
  • back pain
  • coronary arterial stent insertion
  • heart rate irregular
  • heart valve calcification
  • heart valve incompetence
1 - 6 months:
  • back pain
  • cardiac failure congestive
  • chronic obstructive pulmonary disease
  • coronary arterial stent insertion
  • heart rate irregular
  • heart valve calcification
  • heart valve incompetence
  • labile blood pressure
  • loss of consciousness
  • syncope
6 - 12 months:
  • back pain
  • cardiac failure congestive
  • chronic obstructive pulmonary disease
  • coronary arterial stent insertion
  • heart rate irregular
  • heart valve calcification
  • heart valve incompetence
  • labile blood pressure
  • loss of consciousness
  • syncope
1 - 2 years:
  • cardiac failure congestive
  • chronic obstructive pulmonary disease
  • gastritis
  • cardiac disorder
  • dyspnoea
  • pyrexia
  • renal failure
  • abdominal pain upper
  • acute pulmonary oedema
  • bronchitis acute
2 - 5 years:
  • fall
  • type 2 diabetes mellitus
  • ataxia
  • dysarthria
  • insomnia
  • ventricular extrasystoles
  • depression
  • diabetes mellitus inadequate control
  • diabetic neuropathy
  • dizziness
5 - 10 years:
  • depression
  • obesity
  • bipolar disorder
  • nausea and vomiting
  • abdominal pain
  • angina pectoris
  • anxiety
  • arterial occlusive disease
  • arteriosclerosis
  • back disorder
10+ years:
  • diabetes mellitus
  • migraine - common
  • nausea
  • platelet count increased
  • vertigo
  • anxiety aggravated
  • back disorder
  • bipolar disorder
  • depression
  • diabetic ketoacidosis
not specified:
  • pain
  • anxiety
  • nausea
  • fatigue
  • depression
  • asthenia
  • dyspnoea
  • back pain
  • pyrexia
  • fall

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • fatigue
  • back pain
  • depression
  • asthenia
  • headache
  • dyspnoea
  • diarrhoea
male:
  • anxiety
  • depression
  • fatigue
  • nausea
  • dyspnoea
  • back pain
  • asthenia
  • pyrexia
  • pain
  • dizziness

Most common drug interactions by age *:

0-1:
  • foetal growth retardation
  • drug exposure during pregnancy
  • maternal drugs affecting foetus
  • abdominal compartment syndrome
  • agitation neonatal
  • anxiety
  • ascites
  • asthma
  • blood lactic acid increased
  • bronchitis
2-9:
  • eyelid ptosis
  • activated partial thromboplastin time abnormal
  • agitation
  • choking
  • cough
  • depressed level of consciousness
  • disseminated intravascular coagulation
  • drug maladministration
  • dry skin
  • ear disorder
10-19:
  • completed suicide
  • injury
  • irritability
  • suicidal ideation
  • abnormal behaviour
  • affect lability
  • asphyxia
  • confusional state
  • depersonalisation
  • drug withdrawal syndrome
20-29:
  • dizziness
  • vomiting
  • anxiety
  • pyrexia
  • diarrhoea
  • dyspnoea
  • depression
  • headache
  • pain
  • back pain
30-39:
  • anxiety
  • depression
  • fatigue
  • dyspnoea
  • asthenia
  • headache
  • pain
  • hypoaesthesia
  • suicidal ideation
  • vomiting
40-49:
  • pain
  • fatigue
  • back pain
  • dyspnoea
  • nausea
  • headache
  • chest pain
  • depression
  • asthenia
  • constipation
50-59:
  • nausea
  • pain
  • anxiety
  • depression
  • fall
  • headache
  • fatigue
  • anaemia
  • pyrexia
  • bone disorder
60+:
  • back pain
  • pain
  • chronic obstructive pulmonary disease
  • dyspnoea
  • asthenia
  • fall
  • cardiac failure congestive
  • syncope
  • anxiety
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Lorazepam (lorazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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