Review: taking Amitriptyline hydrochloride and Wellbutrin together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Wellbutrin together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Wellbutrin. It is created by eHealthMe based on reports of 2,061 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 8,334 users)

Wellbutrin

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin 69,048 users)

On Sep, 16, 2016

2,061 people who take Amitriptyline Hydrochloride, Wellbutrin are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Wellbutrin drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 18.0% - (2 of 11 people)
  • 1 - 6 months: 25.0% - (5 of 20 people)
  • 6 - 12 months: 25.0% - (2 of 8 people)
  • 1 - 2 years: 50.0% - (10 of 20 people)
  • 2 - 5 years: 41.0% - (7 of 17 people)
  • 5 - 10 years: 35.0% - (6 of 17 people)
  • 10+ years: 42.0% - (3 of 7 people)
  • not specified: 0.0% - (0 of 1 people)
Wellbutrin:
  • < 1 month: 22.0% - (2 of 9 people)
  • 1 - 6 months: 11.0% - (2 of 17 people)
  • 6 - 12 months: 35.0% - (6 of 17 people)
  • 1 - 2 years: 29.0% - (5 of 17 people)
  • 2 - 5 years: 35.0% - (10 of 28 people)
  • 5 - 10 years: 58.0% - (10 of 17 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 34.0% - (27 of 78 people)
  • male: 34.0% - (8 of 23 people)
Wellbutrin:
  • female: 37.0% - (32 of 85 people)
  • male: 26.0% - (7 of 26 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 28.0% - (4 of 14 people)
  • 30-39: 26.0% - (7 of 26 people)
  • 40-49: 41.0% - (10 of 24 people)
  • 50-59: 40.0% - (12 of 30 people)
  • 60+: 16.0% - (1 of 6 people)
Wellbutrin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 52.0% - (10 of 19 people)
  • 30-39: 25.0% - (7 of 28 people)
  • 40-49: 40.0% - (10 of 25 people)
  • 50-59: 33.0% - (10 of 30 people)
  • 60+: 14.0% - (1 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • constipation
  • drug ineffective
  • aggression
  • anxiety
  • insomnia
  • agitation
  • amnesia
  • depression
  • dyskinesia
  • fatigue
1 - 6 months:
  • depression
  • fatigue
  • anxiety
  • headache
  • suicide attempt
  • pain
  • bipolar disorder
  • eye pain
  • fibromyalgia
  • libido increased
6 - 12 months:
  • type 2 diabetes mellitus
  • depression
  • anxiety
  • blood cholesterol increased
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • agoraphobia
  • arthralgia
  • back pain
  • blood triglycerides increased
  • carpal tunnel syndrome
1 - 2 years:
  • fatigue
  • constipation
  • gastrooesophageal reflux disease
  • balance disorder
  • diarrhoea
  • fibromyalgia
  • weight gain
  • abdominal discomfort
  • back pain - low
  • bacteraemia
2 - 5 years:
  • migraine
  • back pain - low
  • fatigue
  • diabetic neuropathy
  • diabetes mellitus inadequate control
  • pain
  • weight increased
  • abdominal obesity
  • arthritis
  • blood glucose increased
5 - 10 years:
  • depression
  • bipolar disorder
  • fatigue
  • anxiety
  • cognitive disorder
  • homicidal ideation
  • loss of consciousness
  • sleep disorder
  • suicidal ideation
  • weight gain
10+ years:
  • constipation
  • weight gain
  • insomnia
  • depression
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • abnormal behaviour
  • anxiety
  • completed suicide
  • dizziness
  • dry mouth
not specified:
  • pain
  • anxiety
  • depression
  • nausea
  • fatigue
  • headache
  • fall
  • arthralgia
  • back pain
  • dyspnoea

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • depression
  • nausea
  • fatigue
  • fall
  • diarrhoea
  • headache
  • arthralgia
  • weight increased
male:
  • pain
  • depression
  • anxiety
  • constipation
  • back pain
  • nausea
  • dizziness
  • arthralgia
  • musculoskeletal pain
  • headache

Most common drug interactions by age *:

0-1:
  • death
  • diabetes mellitus
2-9:
  • hypertension
  • sudden death
  • abdominal distension
  • abdominal pain
  • abnormal behaviour
  • acrochordon
  • amnesia
  • anaemia
  • animal bite
  • anogenital warts
10-19:
  • completed suicide
  • aggression
  • headache
  • nausea
  • syncope
  • fatigue
  • somnolence
  • agitation
  • anger
  • burning sensation
20-29:
  • depression
  • anxiety
  • drug ineffective
  • pain in extremity
  • migraine
  • pain
  • arthralgia
  • dyspnoea
  • memory impairment
  • cellulitis
30-39:
  • depression
  • fatigue
  • pain
  • dyspnoea
  • back pain
  • type 2 diabetes mellitus
  • weight increased
  • nausea
  • anxiety
  • dizziness
40-49:
  • pain
  • depression
  • anxiety
  • back pain
  • chest pain
  • nausea
  • hyperhidrosis
  • type 2 diabetes mellitus
  • asthenia
  • fall
50-59:
  • pain
  • fall
  • nausea
  • anxiety
  • diarrhoea
  • constipation
  • headache
  • arthralgia
  • anaemia
  • fatigue
60+:
  • depression
  • fatigue
  • nausea
  • fall
  • anxiety
  • pain
  • malaise
  • pneumonia
  • asthenia
  • pain in extremity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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