Review: taking Amitriptyline hydrochloride and Zanaflex together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Zanaflex together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Zanaflex. It is created by eHealthMe based on reports of 956 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,380 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 8,329 users)

On Aug, 26, 2016

956 people who take Amitriptyline Hydrochloride, Zanaflex are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Zanaflex drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 22.0% - (2 of 9 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 0.0% - (0 of 4 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Zanaflex:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 7 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 22.0% - (2 of 9 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 16.0% - (4 of 25 people)
  • male: 50.0% - (4 of 8 people)
Zanaflex:
  • female: 12.0% - (3 of 25 people)
  • male: 28.0% - (2 of 7 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 21.0% - (3 of 14 people)
  • 40-49: 28.0% - (2 of 7 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 25.0% - (1 of 4 people)
Zanaflex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 13.0% - (2 of 15 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 0.0% - (0 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • amnesia
  • anxiety
  • asthenia
  • balance disorder
  • cerebrovascular accident
  • cognitive disorder
  • convulsion
  • deafness unilateral
  • diarrhoea
  • dizziness
1 - 6 months:
  • diabetes mellitus
  • diabetic gastroparesis
  • diabetic ketoacidosis
  • diabetic neuropathy
  • hyperglycaemia
  • hysterectomy
  • pancreatitis
  • vomiting
  • charley horse
  • constipation
6 - 12 months:
  • tremor
  • anxiety
  • arthralgia
  • cushingoid
  • dehydration
  • drug withdrawal syndrome
  • duodenal ulcer
  • dyspnoea
  • emotional distress
  • insomnia
1 - 2 years:
  • fatigue
  • constipation
  • headache
  • ataxia
  • dizziness
  • dizziness aggravated
  • nosebleed
  • rectal bleeding
  • abdominal pain
  • fever
2 - 5 years:
  • sleepy
  • sweating - excessive
  • weight gain - unintentional
  • alcohol poisoning
  • alcoholism
  • charley horse
  • constipation
  • depression
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • rapid deep breathing (hyperventilation)
5 - 10 years:
  • dizziness
  • hallucination, visual
  • muscle spasms
10+ years:
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • rapid deep breathing (hyperventilation)
  • weight gain - unintentional
  • muscle fibrosis
  • seizure like phenomena
not specified:
  • pain
  • anxiety
  • drug ineffective
  • fall
  • fatigue
  • nausea
  • constipation
  • chest pain
  • asthenia
  • depression

Most common drug interactions by gender *:

female:
  • fall
  • fatigue
  • pain
  • nausea
  • chest pain
  • anxiety
  • drug ineffective
  • diarrhoea
  • hypertension
  • dyspnoea
male:
  • anxiety
  • depression
  • drug ineffective
  • constipation
  • pain
  • asthenia
  • insomnia
  • headache
  • hypoaesthesia
  • back pain

Most common drug interactions by age *:

20-29:
  • drug ineffective
  • drug dependence
  • convulsion
  • pain
  • pancreatitis
  • cerebrovascular accident
  • constipation
  • drug abuser
  • emotional distress
  • fall
30-39:
  • asthenia
  • insomnia
  • pain
  • anxiety
  • fatigue
  • nausea
  • dyspnoea
  • arthralgia
  • oedema peripheral
  • chest pain
40-49:
  • constipation
  • fatigue
  • anxiety
  • depression
  • back pain
  • headache
  • drug ineffective
  • hypoaesthesia
  • drug dependence
  • drug withdrawal syndrome
50-59:
  • fall
  • hypertension
  • anxiety
  • cough
  • pyrexia
  • anaemia
  • chest pain
  • malnutrition
  • diarrhoea
  • pain
60+:
  • fall
  • dehydration
  • nausea
  • dyspnoea
  • completed suicide
  • diarrhoea
  • asthenia
  • weight decreased
  • drug ineffective
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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