Review: taking Amitriptyline hydrochloride and Zanaflex together


Summary

Drug interactions are reported among people who take Amitriptyline hydrochloride and Zanaflex together. This review analyzes the effectiveness and drug interactions between Amitriptyline hydrochloride and Zanaflex. It is created by eHealthMe based on reports of 1,294 people who take the same drugs from FDA and social media, and is updated regularly.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 8,334 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 10,095 users)

On Sep, 16, 2016

1,294 people who take Amitriptyline Hydrochloride, Zanaflex are studied.


Number of reports submitted per year:

Amitriptyline hydrochloride and Zanaflex drug interactions.

Drug effectiveness over time:

Amitriptyline Hydrochloride:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 22.0% - (2 of 9 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 0.0% - (0 of 4 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Zanaflex:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 7 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 22.0% - (2 of 9 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amitriptyline Hydrochloride:
  • female: 16.0% - (4 of 25 people)
  • male: 50.0% - (4 of 8 people)
Zanaflex:
  • female: 12.0% - (3 of 25 people)
  • male: 28.0% - (2 of 7 people)

Drug effectiveness by age:

Amitriptyline Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 21.0% - (3 of 14 people)
  • 40-49: 28.0% - (2 of 7 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 25.0% - (1 of 4 people)
Zanaflex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 13.0% - (2 of 15 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 0.0% - (0 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • headache
  • nausea
  • amnesia
  • asthenia
  • balance disorder
  • cerebrovascular accident
  • cognitive disorder
  • deafness unilateral
  • diarrhoea
  • dizziness
1 - 6 months:
  • diabetes mellitus
  • diabetic gastroparesis
  • diabetic ketoacidosis
  • diabetic neuropathy
  • hyperglycaemia
  • hysterectomy
  • pancreatitis
  • vomiting
  • abdominal pain
  • activities of daily living impaired
6 - 12 months:
  • tremor
  • anxiety
  • arthralgia
  • cushingoid
  • dehydration
  • drug withdrawal syndrome
  • duodenal ulcer
  • dyspnoea
  • emotional distress
  • insomnia
1 - 2 years:
  • fatigue
  • constipation
  • headache
  • ataxia
  • dizziness
  • dizziness aggravated
  • nosebleed
  • rectal bleeding
  • abdominal pain
  • fever
2 - 5 years:
  • sleepy
  • sweating - excessive
  • weight gain - unintentional
  • alcohol poisoning
  • alcoholism
  • charley horse
  • cognitive disorder
  • constipation
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • rapid deep breathing (hyperventilation)
5 - 10 years:
  • dizziness
  • hallucination, visual
  • muscle spasms
10+ years:
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • rapid deep breathing (hyperventilation)
  • weight gain - unintentional
  • muscle fibrosis
  • seizure like phenomena
not specified:
  • pain
  • drug ineffective
  • fall
  • anxiety
  • fatigue
  • nausea
  • depression
  • asthenia
  • back pain
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • fall
  • fatigue
  • nausea
  • drug ineffective
  • diarrhoea
  • anxiety
  • arthralgia
  • chest pain
  • back pain
male:
  • anxiety
  • drug ineffective
  • depression
  • pain
  • asthenia
  • constipation
  • headache
  • hypoaesthesia
  • back pain
  • insomnia

Most common drug interactions by age *:

10-19:
  • drug ineffective
  • cerebral atrophy
  • confusional state
  • crying
  • discomfort
  • disorientation
  • dystonia
  • fear
  • feeling abnormal
  • hallucination
20-29:
  • drug ineffective
  • nausea
  • pain
  • drug dependence
  • convulsion
  • fall
  • gait disturbance
  • headache
  • pancreatitis
  • rheumatoid arthritis
30-39:
  • pain
  • anxiety
  • asthenia
  • nausea
  • insomnia
  • fatigue
  • dyspnoea
  • arthralgia
  • pain in extremity
  • vomiting
40-49:
  • fatigue
  • anxiety
  • constipation
  • depression
  • headache
  • drug ineffective
  • back pain
  • hypoaesthesia
  • pain
  • nausea
50-59:
  • fall
  • anxiety
  • pain
  • hypertension
  • cough
  • chest pain
  • diarrhoea
  • pyrexia
  • fatigue
  • anaemia
60+:
  • fall
  • nausea
  • diarrhoea
  • pain
  • dehydration
  • asthenia
  • drug ineffective
  • dizziness
  • fatigue
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amitriptyline hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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