Review: taking Amlodipine besylate and Metformin together


Summary

Drug interactions are reported among people who take Amlodipine besylate and Metformin together. This review analyzes the effectiveness and drug interactions between Amlodipine besylate and Metformin. It is created by eHealthMe based on reports of 15,310 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine Besylate

Amlodipine besylate has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine besylate 24,489 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,670 users)

On Sep, 18, 2016

15,310 people who take Amlodipine Besylate, Metformin are studied.


Number of reports submitted per year:

Amlodipine besylate and Metformin drug interactions.

Drug effectiveness over time:

Amlodipine Besylate:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 45.0% - (11 of 24 people)
  • 6 - 12 months: 17.0% - (4 of 23 people)
  • 1 - 2 years: 35.0% - (15 of 42 people)
  • 2 - 5 years: 47.0% - (21 of 44 people)
  • 5 - 10 years: 51.0% - (20 of 39 people)
  • 10+ years: 60.0% - (15 of 25 people)
  • not specified: 0.0% - (0 of 3 people)
Metformin:
  • < 1 month: 42.0% - (3 of 7 people)
  • 1 - 6 months: 17.0% - (4 of 23 people)
  • 6 - 12 months: 38.0% - (7 of 18 people)
  • 1 - 2 years: 39.0% - (13 of 33 people)
  • 2 - 5 years: 31.0% - (18 of 58 people)
  • 5 - 10 years: 41.0% - (20 of 48 people)
  • 10+ years: 64.0% - (16 of 25 people)
  • not specified: 100.0% - (2 of 2 people)

Drug effectiveness by gender:

Amlodipine Besylate:
  • female: 48.0% - (44 of 90 people)
  • male: 36.0% - (44 of 122 people)
Metformin:
  • female: 43.0% - (39 of 89 people)
  • male: 35.0% - (44 of 125 people)

Drug effectiveness by age:

Amlodipine Besylate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 44.0% - (4 of 9 people)
  • 40-49: 55.0% - (15 of 27 people)
  • 50-59: 29.0% - (20 of 68 people)
  • 60+: 44.0% - (48 of 107 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 33.0% - (3 of 9 people)
  • 40-49: 32.0% - (9 of 28 people)
  • 50-59: 41.0% - (28 of 67 people)
  • 60+: 39.0% - (43 of 109 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • hypoglycaemia
  • multi-organ failure
  • renal failure acute
  • headache
  • nausea
  • dyspnoea
  • fatigue
  • hypertension
  • malaise
1 - 6 months:
  • liver function test abnormal
  • respiratory failure
  • hypoglycaemia
  • hypoglycaemic coma
  • renal failure acute
  • vomiting
  • pneumonia
  • syncope
  • urinary tract infection
  • lactic acidosis
6 - 12 months:
  • hypoglycaemia
  • lactic acidosis
  • myalgia
  • presyncope
  • gastrointestinal haemorrhage
  • renal failure acute
  • chest pain
  • dyspnoea
  • metabolic acidosis
  • respiratory tract infection
1 - 2 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • pyrexia
  • dizziness
  • hypotension
  • chest pain
  • hypoglycaemia
  • renal failure acute
2 - 5 years:
  • hypertension
  • type 2 diabetes mellitus
  • atherosclerosis
  • ischaemic stroke
  • lactic acidosis
  • renal failure acute
  • anxiety
  • dyspnoea
  • dizziness
  • myocardial infarction
5 - 10 years:
  • pain
  • anxiety
  • malaise
  • dry mouth
  • renal failure acute
  • injury
  • discomfort
  • emotional distress
  • myocardial infarction
  • depression
10+ years:
  • fatigue
  • dehydration
  • renal failure acute
  • decreased appetite
  • weight decreased
  • asthenia
  • back pain
  • blood creatinine increased
  • cerebrovascular accident
  • diarrhoea
not specified:
  • nausea
  • dyspnoea
  • fatigue
  • diarrhoea
  • pain
  • blood glucose increased
  • drug ineffective
  • dizziness
  • weight decreased
  • vomiting

Most common drug interactions by gender *:

female:
  • nausea
  • diarrhoea
  • dyspnoea
  • fatigue
  • blood glucose increased
  • pain
  • vomiting
  • dizziness
  • drug ineffective
  • hypertension
male:
  • dyspnoea
  • fatigue
  • nausea
  • pain
  • diarrhoea
  • weight decreased
  • myocardial infarction
  • renal failure acute
  • blood glucose increased
  • asthenia

Most common drug interactions by age *:

0-1:
  • facial palsy
  • accident
  • arthritis
  • autoimmune hepatitis
  • balance disorder
  • coma
  • dizziness postural
  • gastrointestinal haemorrhage
  • hepatic steatosis
  • homicidal ideation
2-9:
  • blood glucose fluctuation
  • chest pain
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • fatigue
  • gastrointestinal haemorrhage
  • loss of consciousness
  • malaise
  • nephritis interstitial
10-19:
  • completed suicide
  • intestinal infarction
  • intestinal ischaemia
  • death
  • dizziness
  • haemoglobin increased
  • intestinal obstruction
  • malaise
  • nausea
  • pain in extremity
20-29:
  • metabolic acidosis
  • intentional overdose
  • anxiety
  • cardiac arrest
  • hyperglycaemia
  • completed suicide
  • shock
  • bundle branch block right
  • pain
  • deep vein thrombosis
30-39:
  • diabetes mellitus
  • overdose
  • type 2 diabetes mellitus
  • hypotension
  • headache
  • diabetic neuropathy
  • pain
  • nausea
  • dyspnoea
  • hypertension
40-49:
  • pain
  • diabetes mellitus
  • chest pain
  • nausea
  • dyspnoea
  • type 2 diabetes mellitus
  • hypertension
  • anxiety
  • back pain
  • depression
50-59:
  • nausea
  • fatigue
  • blood glucose increased
  • dyspnoea
  • myocardial infarction
  • headache
  • diarrhoea
  • hypertension
  • dizziness
  • pain
60+:
  • nausea
  • diarrhoea
  • dyspnoea
  • fatigue
  • blood glucose increased
  • renal failure acute
  • asthenia
  • dizziness
  • pain
  • weight decreased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine besylate (amlodipine besylate) is often used to treat high blood pressure. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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