Review: taking Amlodipine besylate and Metformin together


Summary

Drug interactions are reported among people who take Amlodipine besylate and Metformin together. This review analyzes the effectiveness and drug interactions between Amlodipine besylate and Metformin. It is created by eHealthMe based on reports of 10,345 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine Besylate

Amlodipine besylate has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine besylate 20,201 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 122,704 users)

On Aug, 25, 2016

10,345 people who take Amlodipine Besylate, Metformin are studied.


Number of reports submitted per year:

Amlodipine besylate and Metformin drug interactions.

Drug effectiveness over time:

Amlodipine Besylate:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 45.0% - (11 of 24 people)
  • 6 - 12 months: 17.0% - (4 of 23 people)
  • 1 - 2 years: 35.0% - (15 of 42 people)
  • 2 - 5 years: 47.0% - (21 of 44 people)
  • 5 - 10 years: 51.0% - (20 of 39 people)
  • 10+ years: 60.0% - (15 of 25 people)
  • not specified: 0.0% - (0 of 3 people)
Metformin:
  • < 1 month: 42.0% - (3 of 7 people)
  • 1 - 6 months: 17.0% - (4 of 23 people)
  • 6 - 12 months: 38.0% - (7 of 18 people)
  • 1 - 2 years: 39.0% - (13 of 33 people)
  • 2 - 5 years: 30.0% - (18 of 59 people)
  • 5 - 10 years: 41.0% - (20 of 48 people)
  • 10+ years: 66.0% - (16 of 24 people)
  • not specified: 100.0% - (2 of 2 people)

Drug effectiveness by gender:

Amlodipine Besylate:
  • female: 48.0% - (44 of 90 people)
  • male: 36.0% - (44 of 122 people)
Metformin:
  • female: 44.0% - (39 of 88 people)
  • male: 34.0% - (44 of 126 people)

Drug effectiveness by age:

Amlodipine Besylate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 44.0% - (4 of 9 people)
  • 40-49: 55.0% - (15 of 27 people)
  • 50-59: 29.0% - (20 of 68 people)
  • 60+: 44.0% - (48 of 107 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 33.0% - (3 of 9 people)
  • 40-49: 32.0% - (9 of 28 people)
  • 50-59: 41.0% - (28 of 67 people)
  • 60+: 39.0% - (43 of 109 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • multi-organ failure
  • renal failure acute
  • hypoglycaemia
  • dyspnoea
  • nausea
  • toxic epidermal necrolysis
  • malaise
  • metabolic acidosis
  • pain
1 - 6 months:
  • liver function test abnormal
  • respiratory failure
  • renal failure acute
  • vomiting
  • hypoglycaemia
  • pneumonia
  • respiratory distress
  • upper gastrointestinal haemorrhage
  • urinary tract infection
  • blood glucose increased
6 - 12 months:
  • myalgia
  • chest pain
  • dyspnoea
  • respiratory tract infection
  • anxiety
  • amnesia
  • blood pressure diastolic decreased
  • convulsion
  • dizziness
  • generalised oedema
1 - 2 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • pyrexia
  • dizziness
  • hypotension
  • cellulitis
  • diabetic foot infection
  • erectile dysfunction
2 - 5 years:
  • hypertension
  • type 2 diabetes mellitus
  • atherosclerosis
  • ischaemic stroke
  • lactic acidosis
  • renal failure acute
  • dyspnoea
  • anxiety
  • dizziness
  • anaemia
5 - 10 years:
  • pain
  • anxiety
  • dry mouth
  • renal failure acute
  • emotional distress
  • injury
  • myocardial infarction
  • depression
  • discomfort
  • general physical health deterioration
10+ years:
  • renal failure acute
  • back pain
  • blood creatinine increased
  • dyspnoea
  • fatigue
  • headache
  • cerebrovascular accident
  • neck pain
  • blood urea increased
  • dehydration
not specified:
  • nausea
  • dyspnoea
  • pain
  • fatigue
  • blood glucose increased
  • renal failure acute
  • myocardial infarction
  • diarrhoea
  • cardiac failure congestive
  • asthenia

Most common drug interactions by gender *:

female:
  • nausea
  • blood glucose increased
  • dyspnoea
  • fatigue
  • pain
  • vomiting
  • diarrhoea
  • renal failure acute
  • hypertension
  • dizziness
male:
  • dyspnoea
  • pain
  • nausea
  • renal failure acute
  • myocardial infarction
  • fatigue
  • cardiac failure congestive
  • asthenia
  • blood glucose increased
  • weight decreased

Most common drug interactions by age *:

0-1:
  • facial palsy
  • accident
  • arthritis
  • autoimmune hepatitis
  • coma
  • hepatic steatosis
  • homicidal ideation
  • hypertension
  • hypertensive crisis
  • impaired gastric emptying
2-9:
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • loss of consciousness
  • nephritis interstitial
  • pallor
  • syncope
10-19:
  • intestinal infarction
  • intestinal ischaemia
  • haemoglobin increased
  • intestinal obstruction
  • malaise
  • peritoneal adhesions
  • platelet count increased
  • poisoning
  • type 2 diabetes mellitus
  • vasoplegia syndrome
20-29:
  • anxiety
  • pain
  • deep vein thrombosis
  • emotional distress
  • anhedonia
  • general physical health deterioration
  • cholecystitis acute
  • intracardiac thrombus
  • cholecystitis chronic
  • dizziness
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • hypotension
  • diabetic neuropathy
  • overdose
  • headache
  • nausea
  • pain
  • vomiting
  • renal failure acute
40-49:
  • pain
  • diabetes mellitus
  • chest pain
  • type 2 diabetes mellitus
  • depression
  • back pain
  • hypertension
  • completed suicide
  • anxiety
  • dyspnoea
50-59:
  • nausea
  • myocardial infarction
  • fatigue
  • blood glucose increased
  • cardiac failure congestive
  • dyspnoea
  • hypertension
  • chest pain
  • oedema peripheral
  • headache
60+:
  • nausea
  • renal failure acute
  • dyspnoea
  • fatigue
  • blood glucose increased
  • diarrhoea
  • pain
  • asthenia
  • myocardial infarction
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine besylate (amlodipine besylate) is often used to treat high blood pressure. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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