Review: taking Amlodipine besylate and Metformin together


Summary

Drug interactions are reported among people who take Amlodipine besylate and Metformin together. This review analyzes the effectiveness and drug interactions between Amlodipine besylate and Metformin. It is created by eHealthMe based on reports of 7,894 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine Besylate

Amlodipine besylate has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine besylate 18,517 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 97,584 users)

On Jul, 24, 2016

7,894 people who take Amlodipine Besylate, Metformin are studied.


Number of reports submitted per year:

Amlodipine besylate and Metformin drug interactions.

Drug effectiveness over time:

Amlodipine Besylate:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 44.0% - (13 of 29 people)
  • 6 - 12 months: 12.0% - (4 of 32 people)
  • 1 - 2 years: 55.0% - (38 of 69 people)
  • 2 - 5 years: 46.0% - (23 of 49 people)
  • 5 - 10 years: 50.0% - (22 of 44 people)
  • 10+ years: 58.0% - (18 of 31 people)
  • not specified: 0.0% - (0 of 6 people)
Metformin:
  • < 1 month: 42.0% - (3 of 7 people)
  • 1 - 6 months: 16.0% - (4 of 24 people)
  • 6 - 12 months: 36.0% - (7 of 19 people)
  • 1 - 2 years: 34.0% - (15 of 43 people)
  • 2 - 5 years: 45.0% - (40 of 88 people)
  • 5 - 10 years: 45.0% - (27 of 59 people)
  • 10+ years: 62.0% - (18 of 29 people)
  • not specified: 100.0% - (5 of 5 people)

Drug effectiveness by gender:

Amlodipine Besylate:
  • female: 47.0% - (52 of 110 people)
  • male: 41.0% - (68 of 162 people)
Metformin:
  • female: 45.0% - (49 of 107 people)
  • male: 41.0% - (70 of 167 people)

Drug effectiveness by age:

Amlodipine Besylate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 40.0% - (4 of 10 people)
  • 40-49: 51.0% - (16 of 31 people)
  • 50-59: 27.0% - (23 of 85 people)
  • 60+: 52.0% - (76 of 145 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 30.0% - (3 of 10 people)
  • 40-49: 28.0% - (9 of 32 people)
  • 50-59: 40.0% - (34 of 84 people)
  • 60+: 49.0% - (73 of 147 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • multi-organ failure
  • dyspnoea
  • hypoglycaemia
  • toxic epidermal necrolysis
  • nausea
  • metabolic acidosis
  • hypertension
  • restlessness
  • electrolyte imbalance
1 - 6 months:
  • liver function test abnormal
  • respiratory failure
  • respiratory distress
  • upper gastrointestinal haemorrhage
  • urinary tract infection
  • hypoglycaemia
  • pneumonia
  • renal failure acute
  • blood glucose increased
  • neutropenia
6 - 12 months:
  • myalgia
  • chest pain
  • dyspnoea
  • respiratory tract infection
  • anxiety
  • amnesia
  • blood pressure diastolic decreased
  • convulsion
  • haemorrhage
  • muscular weakness
1 - 2 years:
  • atherosclerosis
  • hypertension
  • ischaemic stroke
  • type 2 diabetes mellitus
  • dizziness
  • cellulitis
  • diabetic foot infection
  • erectile dysfunction
  • hypotension
  • osteomyelitis
2 - 5 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • lactic acidosis
  • anxiety
  • dyspnoea
  • cough
  • heart palpitations
  • insomnia
5 - 10 years:
  • anxiety
  • pain
  • dry mouth
  • emotional distress
  • injury
  • depression
  • discomfort
  • general physical health deterioration
  • major depression
  • mobility decreased
10+ years:
  • renal failure acute
  • back pain
  • dyspnoea
  • fatigue
  • cerebrovascular accident
  • headache
  • neck pain
  • blood creatinine increased
  • blood urea increased
  • dehydration
not specified:
  • nausea
  • dyspnoea
  • blood glucose increased
  • pain
  • myocardial infarction
  • fatigue
  • cardiac failure congestive
  • renal failure acute
  • weight decreased
  • diarrhoea

Most common drug interactions by gender *:

female:
  • nausea
  • blood glucose increased
  • dyspnoea
  • fatigue
  • pain
  • vomiting
  • hypertension
  • diarrhoea
  • chest pain
  • dizziness
male:
  • dyspnoea
  • pain
  • myocardial infarction
  • nausea
  • renal failure acute
  • cardiac failure congestive
  • asthenia
  • fatigue
  • anxiety
  • blood glucose increased

Most common drug interactions by age *:

0-1:
  • facial palsy
  • autoimmune hepatitis
  • hypertensive crisis
  • osteoporosis
  • spinal compression fracture
2-9:
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • loss of consciousness
  • nephritis interstitial
  • pallor
  • syncope
10-19:
  • intestinal infarction
  • intestinal ischaemia
  • poisoning
  • type 2 diabetes mellitus
  • vasoplegia syndrome
  • abdominal pain
  • agitation
  • blood glucose abnormal
  • cardiovascular insufficiency
  • circulatory collapse
20-29:
  • anxiety
  • pain
  • deep vein thrombosis
  • emotional distress
  • anhedonia
  • cholecystitis acute
  • general physical health deterioration
  • intracardiac thrombus
  • cholecystitis chronic
  • cholecystitis
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • hypotension
  • diabetic neuropathy
  • headache
  • vomiting
  • overdose
  • diabetic retinopathy
  • dehydration
  • diabetes mellitus inadequate control
40-49:
  • diabetes mellitus
  • pain
  • type 2 diabetes mellitus
  • chest pain
  • back pain
  • diabetes mellitus inadequate control
  • hypertension
  • anxiety
  • dyspnoea
  • nausea
50-59:
  • nausea
  • myocardial infarction
  • cardiac failure congestive
  • blood glucose increased
  • fatigue
  • dyspnoea
  • chest pain
  • hypertension
  • oedema peripheral
  • cerebrovascular accident
60+:
  • nausea
  • dyspnoea
  • renal failure acute
  • blood glucose increased
  • pain
  • fatigue
  • diarrhoea
  • myocardial infarction
  • cardiac failure congestive
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine besylate (amlodipine besylate) is often used to treat high blood pressure. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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