Review: taking Amlodipine and Simvastatin together


Summary

Drug interactions are reported among people who take Amlodipine and Simvastatin together. This review analyzes the effectiveness and drug interactions between Amlodipine and Simvastatin. It is created by eHealthMe based on reports of 13,295 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine 60,844 users)

Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 98,710 users)

On Aug, 29, 2016

13,295 people who take Amlodipine, Simvastatin are studied.


Number of reports submitted per year:

Amlodipine and Simvastatin drug interactions.

Drug effectiveness over time:

Amlodipine:
  • < 1 month: 11.0% - (1 of 9 people)
  • 1 - 6 months: 31.0% - (12 of 38 people)
  • 6 - 12 months: 28.0% - (10 of 35 people)
  • 1 - 2 years: 33.0% - (16 of 48 people)
  • 2 - 5 years: 57.0% - (42 of 73 people)
  • 5 - 10 years: 51.0% - (23 of 45 people)
  • 10+ years: 66.0% - (14 of 21 people)
  • not specified: 0.0% - (0 of 0 people)
Simvastatin:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 28.0% - (8 of 28 people)
  • 6 - 12 months: 24.0% - (7 of 29 people)
  • 1 - 2 years: 38.0% - (18 of 47 people)
  • 2 - 5 years: 52.0% - (37 of 70 people)
  • 5 - 10 years: 62.0% - (31 of 50 people)
  • 10+ years: 80.0% - (21 of 26 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amlodipine:
  • female: 45.0% - (50 of 111 people)
  • male: 43.0% - (68 of 158 people)
Simvastatin:
  • female: 40.0% - (42 of 104 people)
  • male: 52.0% - (81 of 154 people)

Drug effectiveness by age:

Amlodipine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 38.0% - (5 of 13 people)
  • 40-49: 44.0% - (13 of 29 people)
  • 50-59: 27.0% - (17 of 61 people)
  • 60+: 50.0% - (82 of 164 people)
Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 27.0% - (3 of 11 people)
  • 40-49: 53.0% - (14 of 26 people)
  • 50-59: 37.0% - (22 of 59 people)
  • 60+: 52.0% - (84 of 160 people)

Most common drug interactions over time *:

< 1 month:
  • renal failure acute
  • fatigue
  • myalgia
  • rhabdomyolysis
  • depression
  • renal failure
  • dyspnoea
  • pruritus
  • blood creatine phosphokinase increased
  • dizziness
1 - 6 months:
  • renal failure acute
  • hypertension
  • rhabdomyolysis
  • myalgia
  • local swelling
  • muscle spasms
  • myocardial infarction
  • dizziness
  • renal failure
  • chest pain
6 - 12 months:
  • myalgia
  • alveolitis
  • blood creatine phosphokinase increased
  • muscular weakness
  • diabetes mellitus
  • alopecia
  • androgenetic alopecia
  • myositis
  • transaminases increased
  • abdominal pain
1 - 2 years:
  • myalgia
  • dyspnoea
  • rhabdomyolysis
  • dizziness
  • fatigue
  • chest pain
  • asthenia
  • anxiety
  • depression
  • cough
2 - 5 years:
  • myalgia
  • arthralgia
  • pain
  • muscle atrophy
  • muscle spasms
  • cardiac disorder
  • dry mouth
  • pain in extremity
  • back pain
  • disturbance in attention
5 - 10 years:
  • anxiety
  • myocardial infarction
  • pain
  • cerebrovascular accident
  • dyspnoea
  • rhabdomyolysis
  • cardiac failure congestive
  • depression
  • oedema peripheral
  • rash
10+ years:
  • back pain
  • intervertebral disc protrusion
  • injury
  • depression
  • infection
  • sciatica
  • weight decreased
  • blood cholesterol increased
  • fall
  • femur fracture
not specified:
  • nausea
  • dyspnoea
  • pain
  • fatigue
  • dizziness
  • diarrhoea
  • asthenia
  • chest pain
  • anxiety
  • fall

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • fall
  • diarrhoea
  • dizziness
  • oedema peripheral
  • vomiting
  • anxiety
male:
  • dyspnoea
  • pain
  • renal failure acute
  • asthenia
  • fatigue
  • chest pain
  • dizziness
  • myocardial infarction
  • anxiety
  • cardiac failure congestive

Most common drug interactions by age *:

0-1:
  • pneumonia
  • renal impairment
  • accident
  • anxiety
  • arthritis
  • atelectasis
  • blood chloride increased
  • bronchoalveolar lavage abnormal
  • cardiac failure
  • cold sweat
2-9:
  • cardiac valve disease
  • cerebrovascular accident
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • loss of consciousness
  • pallor
  • paralysis
  • syncope
10-19:
  • fall
  • acute myocardial infarction
  • chest pain
  • dehydration
  • dizziness
  • impaired healing
  • lymphangioma
  • pyrexia
  • rales
  • vomiting
20-29:
  • hypotension
  • nausea
  • rhabdomyolysis
  • vomiting
  • diarrhoea
  • lung infiltration
  • metabolic acidosis
  • renal failure
  • renal tubular necrosis
  • fall
30-39:
  • dizziness
  • blood cholesterol increased
  • gastrooesophageal reflux disease
  • cough
  • insomnia
  • depression
  • hypertension
  • abdominal pain upper
  • cardiac failure congestive
  • sleep apnoea syndrome
40-49:
  • pain
  • anxiety
  • fatigue
  • nausea
  • dyspnoea
  • depression
  • dizziness
  • chest pain
  • back pain
  • asthenia
50-59:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • anxiety
  • diarrhoea
  • chest pain
  • asthenia
  • myocardial infarction
  • renal failure
60+:
  • dyspnoea
  • nausea
  • pain
  • fatigue
  • fall
  • dizziness
  • asthenia
  • diarrhoea
  • renal failure acute
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine (amlodipine besylate) is often used to treat high blood pressure. Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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