Review: taking Amlodipine and Simvastatin together


Summary

Drug interactions are reported among people who take Amlodipine and Simvastatin together. This review analyzes the effectiveness and drug interactions between Amlodipine and Simvastatin. It is created by eHealthMe based on reports of 10,400 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine 47,361 users)

Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 78,858 users)

On Jul, 24, 2016

10,400 people who take Amlodipine, Simvastatin are studied.


Number of reports submitted per year:

Amlodipine and Simvastatin drug interactions.

Drug effectiveness over time:

Amlodipine:
  • < 1 month: 11.0% - (1 of 9 people)
  • 1 - 6 months: 30.0% - (13 of 42 people)
  • 6 - 12 months: 27.0% - (10 of 37 people)
  • 1 - 2 years: 30.0% - (17 of 56 people)
  • 2 - 5 years: 55.0% - (47 of 84 people)
  • 5 - 10 years: 47.0% - (29 of 61 people)
  • 10+ years: 66.0% - (16 of 24 people)
  • not specified: 0.0% - (0 of 0 people)
Simvastatin:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 29.0% - (9 of 31 people)
  • 6 - 12 months: 25.0% - (8 of 32 people)
  • 1 - 2 years: 35.0% - (19 of 53 people)
  • 2 - 5 years: 45.0% - (39 of 85 people)
  • 5 - 10 years: 60.0% - (36 of 60 people)
  • 10+ years: 74.0% - (23 of 31 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amlodipine:
  • female: 44.0% - (59 of 134 people)
  • male: 41.0% - (74 of 179 people)
Simvastatin:
  • female: 38.0% - (48 of 125 people)
  • male: 49.0% - (87 of 175 people)

Drug effectiveness by age:

Amlodipine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 27.0% - (5 of 18 people)
  • 40-49: 41.0% - (15 of 36 people)
  • 50-59: 32.0% - (23 of 70 people)
  • 60+: 47.0% - (89 of 187 people)
Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 18.0% - (3 of 16 people)
  • 40-49: 51.0% - (17 of 33 people)
  • 50-59: 32.0% - (22 of 68 people)
  • 60+: 51.0% - (93 of 181 people)

Most common drug interactions over time *:

< 1 month:
  • renal failure
  • dyspnoea
  • fatigue
  • myalgia
  • renal failure acute
  • rhabdomyolysis
  • blood creatine phosphokinase increased
  • epilepsy
  • hypersensitivity
  • pancreatitis
1 - 6 months:
  • rhabdomyolysis
  • renal failure
  • dizziness
  • gastrointestinal haemorrhage
  • myalgia
  • oedema peripheral
  • colitis
  • diarrhoea
  • myopathy
  • chest pain
6 - 12 months:
  • alveolitis
  • myalgia
  • alopecia
  • androgenetic alopecia
  • diabetes mellitus
  • transaminases increased
  • anxiety
  • hypertension
  • asthenia
  • chest pain
1 - 2 years:
  • rhabdomyolysis
  • dizziness
  • dyspnoea
  • chest pain
  • asthenia
  • anxiety
  • myalgia
  • pain in extremity
  • depression
  • cerebrovascular accident
2 - 5 years:
  • myalgia
  • pain
  • depression
  • muscle atrophy
  • arthralgia
  • dizziness
  • cardiac disorder
  • dry mouth
  • hypertension
  • muscle spasms
5 - 10 years:
  • anxiety
  • pain
  • cerebrovascular accident
  • myocardial infarction
  • dyspnoea
  • rhabdomyolysis
  • cardiac failure congestive
  • depression
  • emotional distress
  • general physical health deterioration
10+ years:
  • intervertebral disc protrusion
  • injury
  • weight decreased
  • blood cholesterol increased
  • depression
  • infection
  • sciatica
  • drug ineffective
  • fatigue
  • back pain
not specified:
  • nausea
  • dyspnoea
  • pain
  • fatigue
  • anxiety
  • chest pain
  • dizziness
  • asthenia
  • oedema peripheral
  • diarrhoea

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • fall
  • oedema peripheral
  • anxiety
  • diarrhoea
  • dizziness
  • asthenia
male:
  • dyspnoea
  • pain
  • chest pain
  • cardiac failure congestive
  • renal failure
  • anxiety
  • dizziness
  • asthenia
  • myocardial infarction
  • fatigue

Most common drug interactions by age *:

0-1:
  • pneumonia
  • renal impairment
  • anxiety
  • atelectasis
  • blood chloride increased
  • bronchoalveolar lavage abnormal
  • cardiac failure
  • cold sweat
  • confusional state
  • disseminated intravascular coagulation
2-9:
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • loss of consciousness
  • pallor
  • syncope
10-19:
  • lymphangioma
  • alopecia
  • back pain
  • blood parathyroid hormone increased
  • calcinosis
  • dehydration
  • drug effect decreased
  • fluid retention
  • fluorosis
  • general physical health deterioration
20-29:
  • hypotension
  • asthenia
  • abdominal pain
  • blood creatinine increased
  • dehydration
  • gastrointestinal disorder
  • anaphylactic reaction
  • bloody peritoneal effluent
  • contusion
  • dyspnoea
30-39:
  • dizziness
  • blood cholesterol increased
  • insomnia
  • cough
  • hypertension
  • sleep apnoea syndrome
  • abdominal pain upper
  • angina pectoris
  • cardiac failure congestive
  • depression
40-49:
  • anxiety
  • pain
  • nausea
  • dyspnoea
  • chest pain
  • fatigue
  • depression
  • dizziness
  • myocardial infarction
  • pain in extremity
50-59:
  • nausea
  • pain
  • anxiety
  • myocardial infarction
  • renal failure
  • chest pain
  • dyspnoea
  • asthenia
  • depression
  • diarrhoea
60+:
  • dyspnoea
  • nausea
  • pain
  • fatigue
  • dizziness
  • fall
  • asthenia
  • chest pain
  • renal failure
  • anxiety

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine (amlodipine besylate) is often used to treat high blood pressure. Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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