Review: taking Amlodipine and Simvastatin together


Summary

Drug interactions are reported among people who take Amlodipine and Simvastatin together. This review analyzes the effectiveness and drug interactions between Amlodipine and Simvastatin. It is created by eHealthMe based on reports of 17,483 people who take the same drugs from FDA and social media, and is updated regularly.

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Amlodipine

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine 93,539 users)

Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 131,413 users)

On Sep, 20, 2016

17,483 people who take Amlodipine, Simvastatin are studied.


Number of reports submitted per year:

Amlodipine and Simvastatin drug interactions.

Drug effectiveness over time:

Amlodipine:
  • < 1 month: 11.0% - (1 of 9 people)
  • 1 - 6 months: 30.0% - (12 of 39 people)
  • 6 - 12 months: 27.0% - (10 of 36 people)
  • 1 - 2 years: 33.0% - (16 of 48 people)
  • 2 - 5 years: 56.0% - (42 of 74 people)
  • 5 - 10 years: 51.0% - (23 of 45 people)
  • 10+ years: 65.0% - (13 of 20 people)
  • not specified: 0.0% - (0 of 0 people)
Simvastatin:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 27.0% - (8 of 29 people)
  • 6 - 12 months: 23.0% - (7 of 30 people)
  • 1 - 2 years: 38.0% - (18 of 47 people)
  • 2 - 5 years: 52.0% - (37 of 70 people)
  • 5 - 10 years: 62.0% - (31 of 50 people)
  • 10+ years: 80.0% - (20 of 25 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Amlodipine:
  • female: 43.0% - (49 of 112 people)
  • male: 42.0% - (68 of 159 people)
Simvastatin:
  • female: 39.0% - (41 of 104 people)
  • male: 52.0% - (81 of 155 people)

Drug effectiveness by age:

Amlodipine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 38.0% - (5 of 13 people)
  • 40-49: 43.0% - (13 of 30 people)
  • 50-59: 27.0% - (17 of 61 people)
  • 60+: 49.0% - (81 of 165 people)
Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 27.0% - (3 of 11 people)
  • 40-49: 51.0% - (14 of 27 people)
  • 50-59: 37.0% - (22 of 59 people)
  • 60+: 51.0% - (83 of 160 people)

Most common drug interactions over time *:

< 1 month:
  • myalgia
  • fatigue
  • renal failure acute
  • renal failure
  • rhabdomyolysis
  • dyspnoea
  • abdominal pain upper
  • depression
  • dizziness
  • pneumonia
1 - 6 months:
  • renal failure acute
  • hypertension
  • myalgia
  • rhabdomyolysis
  • local swelling
  • muscle spasms
  • myocardial infarction
  • pain
  • pain in extremity
  • paraesthesia
6 - 12 months:
  • myalgia
  • alveolitis
  • blood creatine phosphokinase increased
  • muscular weakness
  • diabetes mellitus
  • abdominal pain
  • alopecia
  • androgenetic alopecia
  • myositis
  • transaminases increased
1 - 2 years:
  • myalgia
  • fatigue
  • dizziness
  • dyspnoea
  • gait disturbance
  • rhabdomyolysis
  • paraesthesia
  • asthenia
  • chest pain
  • cough
2 - 5 years:
  • arthralgia
  • muscle atrophy
  • myalgia
  • pain in extremity
  • asthenia
  • pain
  • chest pain
  • dizziness
  • dyspnoea
  • muscle spasms
5 - 10 years:
  • dyspnoea
  • atrial fibrillation
  • myocardial infarction
  • anxiety
  • asthenia
  • pain in extremity
  • arthralgia
  • fatigue
  • gastrointestinal haemorrhage
  • cardiac failure congestive
10+ years:
  • fatigue
  • back pain
  • cough
  • arthralgia
  • intervertebral disc protrusion
  • cerebrovascular accident
  • fall
  • injury
  • pain in extremity
  • arthritis
not specified:
  • dyspnoea
  • nausea
  • fatigue
  • pain
  • diarrhoea
  • dizziness
  • asthenia
  • fall
  • drug ineffective
  • chest pain

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • fatigue
  • pain
  • fall
  • diarrhoea
  • dizziness
  • asthenia
  • vomiting
  • pain in extremity
male:
  • dyspnoea
  • fatigue
  • pain
  • asthenia
  • renal failure acute
  • dizziness
  • chest pain
  • myocardial infarction
  • diarrhoea
  • pneumonia

Most common drug interactions by age *:

0-1:
  • pneumonia
  • renal impairment
  • accident
  • anxiety
  • arthritis
  • atelectasis
  • blood chloride increased
  • bronchoalveolar lavage abnormal
  • cardiac failure
  • cold sweat
2-9:
  • cardiac valve disease
  • cerebrovascular accident
  • diarrhoea
  • duodenal ulcer haemorrhage
  • faeces discoloured
  • gastrointestinal haemorrhage
  • loss of consciousness
  • pallor
  • paralysis
  • syncope
10-19:
  • vomiting
  • arthralgia
  • blood creatine phosphokinase increased
  • fall
  • malaise
  • musculoskeletal pain
  • rhabdomyolysis
  • acute myocardial infarction
  • brain stem glioma
  • cerebrovascular accident
20-29:
  • hypotension
  • nausea
  • rhabdomyolysis
  • vomiting
  • diarrhoea
  • lung infiltration
  • metabolic acidosis
  • renal failure
  • renal tubular necrosis
  • fall
30-39:
  • dizziness
  • blood cholesterol increased
  • cough
  • fall
  • gastrooesophageal reflux disease
  • blood creatinine increased
  • depression
  • insomnia
  • muscular weakness
  • sleep apnoea syndrome
40-49:
  • pain
  • fatigue
  • anxiety
  • nausea
  • dyspnoea
  • depression
  • dizziness
  • chest pain
  • asthenia
  • myocardial infarction
50-59:
  • fatigue
  • nausea
  • dyspnoea
  • pain
  • diarrhoea
  • asthenia
  • anxiety
  • chest pain
  • depression
  • myocardial infarction
60+:
  • dyspnoea
  • nausea
  • fatigue
  • pain
  • diarrhoea
  • fall
  • asthenia
  • dizziness
  • pneumonia
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Amlodipine (amlodipine besylate) is often used to treat high blood pressure. Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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