Review: taking Antabuse and Zoloft together


Summary

Drug interactions are reported among people who take Antabuse and Zoloft together. This review analyzes the effectiveness and drug interactions between Antabuse and Zoloft. It is created by eHealthMe based on reports of 78 people who take the same drugs from FDA and social media, and is updated regularly.

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Antabuse

Antabuse has active ingredients of disulfiram. It is often used in alcoholism. (latest outcomes from Antabuse 953 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 97,228 users)

On Sep, 20, 2016

78 people who take Antabuse, Zoloft are studied.


Number of reports submitted per year:

Antabuse and Zoloft drug interactions.

Drug effectiveness over time:

Antabuse:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Zoloft:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 100.0% - (3 of 3 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 0 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Antabuse:
  • female: 60.0% - (3 of 5 people)
  • male: 100.0% - (1 of 1 people)
Zoloft:
  • female: 83.0% - (5 of 6 people)
  • male: 0.0% - (0 of 2 people)

Drug effectiveness by age:

Antabuse:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • abdominal pain
  • hepatitis
  • malaise
  • vomiting
1 - 6 months:
  • activities of daily living impaired
  • alcoholic
  • amnesia
  • communication disorder
  • confusional state
  • coordination abnormal
  • fall
  • impaired self-care
  • impaired work ability
  • injury
1 - 2 years:
  • alcoholic
10+ years:
  • deafness unilateral
  • hepatitis c
  • nephrolithiasis
  • splenomegaly
  • thrombocytopenia
  • age indeterminate myocardial infarction
  • asthenia
  • deafness neurosensory
  • deafness transitory
  • epistaxis
not specified:
  • haemoglobin decreased
  • cardiac arrest
  • hepatitis c
  • ceruloplasmin increased
  • neutrophil count decreased
  • platelet count decreased
  • suicidal ideation
  • white blood cell count decreased
  • asthenia
  • sedation

Most common drug interactions by gender *:

female:
  • breast pain
  • cardiac arrest
  • drug ineffective
  • hyperprolactinaemia
  • lactic acidosis
  • nausea
  • shock
  • vomiting
  • abdominal pain
  • alcoholic
male:
  • haemoglobin decreased
  • hepatitis c
  • asthenia
  • cardiac arrest
  • ceruloplasmin increased
  • neutrophil count decreased
  • platelet count decreased
  • suicidal ideation
  • white blood cell count decreased
  • sedation

Most common drug interactions by age *:

10-19:
  • appetite decreased
  • constipation
  • drug screen positive
  • fatigue
  • hepatic failure
  • liver transplant
  • nausea
  • necrosis
  • peptic ulcer
  • urine discolouration
20-29:
  • blood lactate dehydrogenase increased
  • haematocrit decreased
  • haemoglobin decreased
  • haemolytic anaemia
  • haptoglobin decreased
  • mean cell volume increased
  • red blood cell count decreased
  • red blood cell morphology abnormal
  • grand mal convulsion
  • haemolysis
30-39:
  • pyrexia
  • amnesia
  • anxiety
  • depressed level of consciousness
  • diabetes mellitus
  • disorientation
  • disturbance in attention
  • disturbance in sexual arousal
  • hypersensitivity
  • injection site induration
40-49:
  • ceruloplasmin increased
  • haemoglobin decreased
  • hepatitis c
  • neutrophil count decreased
  • platelet count decreased
  • white blood cell count decreased
  • blood carbon dioxide increased
  • cardiac arrest
  • hyperpyrexia malignant
  • sedation
50-59:
  • cardiac arrest
  • diarrhoea
  • lactic acidosis
  • shock
  • vomiting
  • abnormal dreams
  • anorexia
  • arthralgia
  • asthenia
  • back pain
60+:
  • injury
  • myocardial infarction
  • ventricular extrasystoles
  • abdominal distension
  • abdominal pain
  • abdominal pain upper
  • acquired cardiac septal defect
  • activities of daily living impaired
  • alopecia
  • amnesia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Antabuse (disulfiram) is often used to treat alcoholism. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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