Review: taking Benadryl and Clonazepam together


Summary

Drug interactions are reported among people who take Benadryl and Clonazepam together. This review analyzes the effectiveness and drug interactions between Benadryl and Clonazepam. It is created by eHealthMe based on reports of 2,840 people who take the same drugs from FDA and social media, and is updated regularly.

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Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

Clonazepam

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 60,448 users)

On Sep, 16, 2016

2,840 people who take Benadryl, Clonazepam are studied.


Number of reports submitted per year:

Benadryl and Clonazepam drug interactions.

Drug effectiveness over time:

Benadryl:
  • < 1 month: 31.0% - (7 of 22 people)
  • 1 - 6 months: 38.0% - (5 of 13 people)
  • 6 - 12 months: 60.0% - (6 of 10 people)
  • 1 - 2 years: 45.0% - (5 of 11 people)
  • 2 - 5 years: 41.0% - (5 of 12 people)
  • 5 - 10 years: 37.0% - (6 of 16 people)
  • 10+ years: 63.0% - (7 of 11 people)
  • not specified: 100.0% - (3 of 3 people)
Clonazepam:
  • < 1 month: 29.0% - (5 of 17 people)
  • 1 - 6 months: 31.0% - (6 of 19 people)
  • 6 - 12 months: 37.0% - (3 of 8 people)
  • 1 - 2 years: 80.0% - (4 of 5 people)
  • 2 - 5 years: 45.0% - (11 of 24 people)
  • 5 - 10 years: 64.0% - (11 of 17 people)
  • 10+ years: 76.0% - (10 of 13 people)
  • not specified: 100.0% - (2 of 2 people)

Drug effectiveness by gender:

Benadryl:
  • female: 44.0% - (34 of 76 people)
  • male: 45.0% - (10 of 22 people)
Clonazepam:
  • female: 49.0% - (40 of 81 people)
  • male: 50.0% - (12 of 24 people)

Drug effectiveness by age:

Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 75.0% - (3 of 4 people)
  • 20-29: 40.0% - (8 of 20 people)
  • 30-39: 41.0% - (10 of 24 people)
  • 40-49: 40.0% - (8 of 20 people)
  • 50-59: 57.0% - (12 of 21 people)
  • 60+: 33.0% - (3 of 9 people)
Clonazepam:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 60.0% - (3 of 5 people)
  • 20-29: 47.0% - (11 of 23 people)
  • 30-39: 50.0% - (12 of 24 people)
  • 40-49: 34.0% - (8 of 23 people)
  • 50-59: 71.0% - (15 of 21 people)
  • 60+: 33.0% - (3 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • cystitis haemorrhagic
  • sepsis
  • headache
  • hypotension
  • bk virus infection
  • cytomegalovirus infection
  • dehydration
  • hyperbilirubinaemia
  • mucosal inflammation
  • pneumonia
1 - 6 months:
  • depression
  • arthritis
  • pseudoporphyria
  • feeling jittery
  • restlessness aggravated
  • anxiety
  • anxiety disorder
  • constipation
  • depression suicidal
  • facial nerve disorder
6 - 12 months:
  • feeling jittery
  • depression
  • restlessness aggravated
  • pneumonia
  • cardiomegaly
  • choledochal cyst
  • cyanosis neonatal
  • headache
  • infusion related reaction
  • neonatal respiratory distress syndrome
1 - 2 years:
  • anaemia
  • nausea
  • abdominal wall haematoma
  • back pain
  • chronic obstructive pulmonary disease
  • dizziness
  • hypoglycaemia
  • insomnia
  • pelvic haematoma
  • rash
2 - 5 years:
  • anger
  • injury
  • pain exacerbated
  • stress
  • acute hepatic failure
  • aggression aggravated
  • anxiety
  • bipolar disorder
  • bradycardia
  • cholelithiasis
5 - 10 years:
  • arthritis
  • pseudoporphyria
  • anxiety
  • anxiety disorder
  • constipation
  • depression
  • depression suicidal
  • facial nerve disorder
  • facial nerve palsy
  • facial pain
10+ years:
  • back pain aggravated
  • dizziness
  • lightheadedness
  • itching
  • breathing difficulty - lying down
  • breathing sounds
  • chronic pain
  • sinusitis
  • syncope vasovagal
  • accidental death
not specified:
  • pain
  • nausea
  • headache
  • depression
  • fatigue
  • anxiety
  • insomnia
  • fall
  • dyspnoea
  • vomiting

Most common drug interactions by gender *:

female:
  • pain
  • headache
  • depression
  • nausea
  • fatigue
  • fall
  • insomnia
  • anxiety
  • dyspnoea
  • vomiting
male:
  • drug abuse
  • pain
  • death
  • anxiety
  • fatigue
  • depression
  • nausea
  • headache
  • dyspnoea
  • dizziness

Most common drug interactions by age *:

0-1:
  • diarrhoea
  • foetal exposure during pregnancy
  • nasal congestion
  • pulmonary hypertension
  • anaemia
  • blood urea decreased
  • bone marrow failure
  • carbon dioxide increased
  • clostridium difficile colitis
  • dermatitis
2-9:
  • death
  • abnormal behaviour
  • convulsion
  • dehydration
  • drug administration error
  • grand mal convulsion
  • seizure
  • suicidal ideation
  • anaemia
  • anxiety
10-19:
  • suicidal ideation
  • weight increased
  • nausea
  • depression
  • fatigue
  • vomiting
  • musculoskeletal stiffness
  • pyrexia
  • abdominal pain upper
  • chest pain
20-29:
  • vomiting
  • completed suicide
  • drug abuse
  • nausea
  • insomnia
  • urinary tract infection
  • death
  • dyspnoea
  • asthenia
  • pericardial effusion
30-39:
  • drug abuse
  • completed suicide
  • nausea
  • death
  • pain
  • headache
  • chest pain
  • anxiety
  • diabetes mellitus
  • vomiting
40-49:
  • depression
  • headache
  • fatigue
  • pain
  • nausea
  • anxiety
  • dyspnoea
  • fall
  • pneumonia
  • back pain
50-59:
  • pain
  • fall
  • anxiety
  • headache
  • insomnia
  • nausea
  • depression
  • cough
  • pyrexia
  • dyspnoea
60+:
  • fatigue
  • pain
  • headache
  • anxiety
  • nausea
  • dyspnoea
  • diarrhoea
  • fall
  • anaemia
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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