Review: taking Benadryl and Clonazepam together


Summary

Drug interactions are reported among people who take Benadryl and Clonazepam together. This review analyzes the effectiveness and drug interactions between Benadryl and Clonazepam. It is created by eHealthMe based on reports of 1,783 people who take the same drugs from FDA and social media, and is updated regularly.

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Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)

Clonazepam

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 45,597 users)

On Aug, 18, 2016

1,783 people who take Benadryl, Clonazepam are studied.


Number of reports submitted per year:

Benadryl and Clonazepam drug interactions.

Drug effectiveness over time:

Benadryl:
  • < 1 month: 31.0% - (7 of 22 people)
  • 1 - 6 months: 38.0% - (5 of 13 people)
  • 6 - 12 months: 60.0% - (6 of 10 people)
  • 1 - 2 years: 45.0% - (5 of 11 people)
  • 2 - 5 years: 41.0% - (5 of 12 people)
  • 5 - 10 years: 37.0% - (6 of 16 people)
  • 10+ years: 63.0% - (7 of 11 people)
  • not specified: 100.0% - (3 of 3 people)
Clonazepam:
  • < 1 month: 29.0% - (5 of 17 people)
  • 1 - 6 months: 31.0% - (6 of 19 people)
  • 6 - 12 months: 37.0% - (3 of 8 people)
  • 1 - 2 years: 80.0% - (4 of 5 people)
  • 2 - 5 years: 45.0% - (11 of 24 people)
  • 5 - 10 years: 64.0% - (11 of 17 people)
  • 10+ years: 76.0% - (10 of 13 people)
  • not specified: 100.0% - (2 of 2 people)

Drug effectiveness by gender:

Benadryl:
  • female: 44.0% - (34 of 76 people)
  • male: 45.0% - (10 of 22 people)
Clonazepam:
  • female: 49.0% - (40 of 81 people)
  • male: 50.0% - (12 of 24 people)

Drug effectiveness by age:

Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 75.0% - (3 of 4 people)
  • 20-29: 40.0% - (8 of 20 people)
  • 30-39: 41.0% - (10 of 24 people)
  • 40-49: 40.0% - (8 of 20 people)
  • 50-59: 57.0% - (12 of 21 people)
  • 60+: 33.0% - (3 of 9 people)
Clonazepam:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 60.0% - (3 of 5 people)
  • 20-29: 47.0% - (11 of 23 people)
  • 30-39: 50.0% - (12 of 24 people)
  • 40-49: 34.0% - (8 of 23 people)
  • 50-59: 71.0% - (15 of 21 people)
  • 60+: 33.0% - (3 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • headache
  • cystitis haemorrhagic
  • hypotension
  • bk virus infection
  • cytomegalovirus infection
  • dehydration
  • hyperbilirubinaemia
  • mucosal inflammation
  • sepsis
  • suicidal ideation
1 - 6 months:
  • depression
  • arthritis
  • pseudoporphyria
  • feeling jittery
  • restlessness aggravated
  • anxiety
  • anxiety disorder
  • constipation
  • depression suicidal
  • facial nerve disorder
6 - 12 months:
  • feeling jittery
  • depression
  • restlessness aggravated
  • vision blurred
  • rash pustular
  • adrenal mass
  • arthritis
  • back pain
  • blepharitis
  • blood triglycerides increased
1 - 2 years:
  • adrenal mass
  • antinuclear antibody increased
  • antinuclear factor positive
  • arthritis
  • back pain
  • blepharitis
  • blood bilirubin increased
  • blood iron increased
  • bone and joint pain
  • cerumen impaction
2 - 5 years:
  • anger
  • pain exacerbated
  • stress
  • aggression aggravated
  • bipolar disorder
  • bradycardia
  • cholelithiasis
  • dry skin
  • hallucinations, mixed
  • injury
5 - 10 years:
  • arthritis
  • pseudoporphyria
  • anxiety
  • anxiety disorder
  • constipation
  • depression
  • depression suicidal
  • facial nerve disorder
  • facial nerve palsy
  • facial pain
10+ years:
  • back pain aggravated
  • dizziness
  • lightheadedness
  • itching
  • breathing difficulty - lying down
  • breathing sounds
  • chronic pain
  • syncope vasovagal
  • accidental death
  • aortic valve stenosis
not specified:
  • pain
  • nausea
  • depression
  • anxiety
  • fatigue
  • headache
  • fall
  • insomnia
  • dyspnoea
  • weight increased

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • depression
  • headache
  • fall
  • anxiety
  • insomnia
  • fatigue
  • dyspnoea
  • dizziness
male:
  • pain
  • anxiety
  • depression
  • fatigue
  • dyspnoea
  • nausea
  • weight increased
  • insomnia
  • back pain
  • headache

Most common drug interactions by age *:

0-1:
  • pulmonary hypertension
  • myocarditis post infection
  • nephrolithiasis
  • obstruction gastric
  • pancreatitis
  • type 2 diabetes mellitus
  • urethral stenosis
  • weight increased
2-9:
  • convulsion
  • dehydration
  • drug administration error
  • grand mal convulsion
  • suicidal ideation
  • anaemia
  • anxiety
  • blood pressure increased
  • death
  • depression
10-19:
  • suicidal ideation
  • weight increased
  • nausea
  • fatigue
  • pyrexia
  • abdominal pain upper
  • depression
  • musculoskeletal stiffness
  • drug ineffective
  • weight decreased
20-29:
  • insomnia
  • nausea
  • urinary tract infection
  • vomiting
  • asthenia
  • pericardial effusion
  • dyspnoea
  • abdominal pain upper
  • anaemia
  • upper respiratory tract infection
30-39:
  • nausea
  • completed suicide
  • pain
  • diabetes mellitus
  • anxiety
  • dyspnoea
  • chest pain
  • vomiting
  • headache
  • migraine
40-49:
  • depression
  • headache
  • pain
  • anxiety
  • dyspnoea
  • fall
  • fatigue
  • nausea
  • back pain
  • suicidal ideation
50-59:
  • pain
  • fall
  • anxiety
  • depression
  • insomnia
  • cough
  • pyrexia
  • headache
  • nausea
  • pain in extremity
60+:
  • fatigue
  • pain
  • dyspnoea
  • anxiety
  • nausea
  • hypertension
  • insomnia
  • anaemia
  • depression
  • headache

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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