Benadryl and Zofran drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Benadryl and Zofran together. This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 6,438 people who take the same drugs from FDA, and is updated regularly.

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Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 44,713 users)

Zofran

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (latest outcomes from Zofran 38,117 users)

On Feb, 06, 2017

6,438 people who take Benadryl, Zofran are studied.


Number of reports submitted per year:

Benadryl and Zofran drug interactions.

Most common drug interactions over time *:

< 1 month:
  • febrile neutropenia
  • nausea
  • dyspnoea
  • hypotension
  • pyrexia
  • vomiting
  • pneumonia
  • dehydration
  • diarrhoea
  • hyponatraemia
1 - 6 months:
  • febrile neutropenia
  • sepsis
  • hypotension
  • nausea
  • dehydration
  • acute respiratory failure
  • haemorrhage intracranial
  • failure to thrive
  • respiratory failure
  • pyrexia
6 - 12 months:
  • urinary tract infection
  • constipation
  • hyponatraemia
  • nausea
  • confusional state
  • pain
  • asthenia
  • dyspnoea
  • abdominal pain
  • anxiety
1 - 2 years:
  • exostosis
  • osteonecrosis
  • tooth extraction
  • jaw disorder
  • anaemia
  • asthenia
  • bone disorder
  • hyperthyroidism
  • incontinence
  • intervertebral disc protrusion
2 - 5 years:
  • nephrogenic systemic fibrosis
  • pneumonia
  • acute respiratory distress syndrome
  • cardiac arrest
  • coeliac artery compression syndrome
  • constipation
  • drug dependence
  • hepatic necrosis
  • pleural effusion
  • cardiac failure congestive
5 - 10 years:
  • vomiting
  • adverse drug reaction
  • blood potassium decreased
  • constipation
  • drug administration error
  • drug ineffective
10+ years:
  • cellulitis
  • haematoma
  • pyrexia
  • sepsis
  • subdural haematoma
not specified:
  • nausea
  • vomiting
  • fatigue
  • pain
  • dyspnoea
  • pyrexia
  • diarrhoea
  • anxiety
  • anaemia
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • vomiting
  • pain
  • dyspnoea
  • fatigue
  • pyrexia
  • anxiety
  • diarrhoea
  • headache
  • anaemia
male:
  • nausea
  • fatigue
  • pyrexia
  • vomiting
  • dehydration
  • diarrhoea
  • pneumonia
  • dyspnoea
  • death
  • hypotension

Most common drug interactions by age *:

0-1:
  • constipation
  • tachycardia
  • tachypnoea
  • diarrhoea
  • vomiting
  • hypernatraemia
  • hypoxia
  • pyrexia
  • histiocytosis haematophagic
  • sleep apnoea syndrome
2-9:
  • vomiting
  • pyrexia
  • febrile neutropenia
  • diarrhoea
  • nausea
  • dehydration
  • mucosal inflammation
  • hypokalaemia
  • thrombocytopenia
  • hyponatraemia
10-19:
  • hypotension
  • nausea
  • vomiting
  • pyrexia
  • blood bilirubin increased
  • headache
  • hypokalaemia
  • febrile neutropenia
  • crohn's disease
  • dehydration
20-29:
  • nausea
  • pain
  • headache
  • pyrexia
  • vomiting
  • anxiety
  • back pain
  • diarrhoea
  • dyspnoea
  • abdominal pain upper
30-39:
  • nausea
  • pain
  • vomiting
  • dyspnoea
  • pyrexia
  • anaemia
  • fatigue
  • headache
  • abdominal pain
  • anxiety
40-49:
  • nausea
  • vomiting
  • pain
  • pyrexia
  • dyspnoea
  • fatigue
  • back pain
  • chest pain
  • diarrhoea
  • anxiety
50-59:
  • nausea
  • fatigue
  • dyspnoea
  • pain
  • pyrexia
  • vomiting
  • dehydration
  • headache
  • anxiety
  • pneumonia
60+:
  • nausea
  • dyspnoea
  • diarrhoea
  • fatigue
  • vomiting
  • pneumonia
  • pyrexia
  • asthenia
  • dehydration
  • hypotension

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Zofran?

Interactions between Benadryl and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Zofran and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Zofran (ondansetron hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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