Review: taking Benadryl and Zofran together


Summary

Drug interactions are reported among people who take Benadryl and Zofran together. This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 3,345 people who take the same drugs from FDA and social media, and is updated regularly.

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Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

Zofran

Zofran has active ingredients of ondansetron. It is often used in nausea. (latest outcomes from Zofran 22,994 users)

On Jul, 20, 2016

3,345 people who take Benadryl, Zofran are studied.


Number of reports submitted per year:

Benadryl and Zofran drug interactions.

Drug effectiveness over time:

Benadryl:
  • < 1 month: 50.0% - (3 of 6 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)
Zofran:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 75.0% - (3 of 4 people)
  • 6 - 12 months: 66.0% - (2 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Benadryl:
  • female: 58.0% - (7 of 12 people)
  • male: 25.0% - (1 of 4 people)
Zofran:
  • female: 76.0% - (10 of 13 people)
  • male: 0.0% - (0 of 4 people)

Drug effectiveness by age:

Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 0.0% - (0 of 1 people)
Zofran:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 80.0% - (4 of 5 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • hypotension
  • nausea
  • dyspnoea
  • vomiting
  • pyrexia
  • dehydration
  • blood bilirubin increased
  • constipation
  • febrile neutropenia
  • pneumonia
1 - 6 months:
  • febrile neutropenia
  • dehydration
  • sepsis
  • hypotension
  • respiratory failure
  • dermatitis acneiform
  • fall
  • stomatitis
  • nausea
  • tachycardia
6 - 12 months:
  • constipation
  • nausea
  • pain
  • pneumonia
  • abdominal pain
  • abnormal dreams
  • adrenal insufficiency
  • anxiety
  • confusional state
  • dizziness postural
1 - 2 years:
  • osteonecrosis
  • tooth extraction
  • jaw disorder
  • bone disorder
  • exostosis
  • mucosal inflammation
  • gingival disorder
2 - 5 years:
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • cognitive deterioration
  • depression
  • constipation
  • headache
  • nausea
5 - 10 years:
  • burning eyes
  • adverse drug reaction
  • blood potassium decreased
  • constipation
  • drug administration error
  • drug ineffective
  • vomiting
not specified:
  • nausea
  • pain
  • vomiting
  • pyrexia
  • dyspnoea
  • anxiety
  • anaemia
  • dehydration
  • diarrhoea
  • back pain

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • vomiting
  • anxiety
  • dyspnoea
  • anaemia
  • pyrexia
  • back pain
  • fatigue
  • diarrhoea
male:
  • nausea
  • dehydration
  • pyrexia
  • pneumonia
  • vomiting
  • hypotension
  • dyspnoea
  • pain
  • diarrhoea
  • thrombocytopenia

Most common drug interactions by age *:

0-1:
  • pyrexia
  • tachycardia
  • tachypnoea
  • constipation
  • vomiting
  • hepatomegaly
  • bradycardia
  • brain hypoxia
  • cardio-respiratory arrest
  • circulatory collapse
2-9:
  • vomiting
  • diarrhoea
  • nausea
  • asthenia
  • pyrexia
  • abdominal pain
  • constipation
  • dry skin
  • lipase increased
  • pericardial effusion
10-19:
  • hypotension
  • blood bilirubin increased
  • vomiting
  • nausea
  • pyrexia
  • pain
  • headache
  • pneumonitis
  • acute respiratory distress syndrome
  • neutropenia
20-29:
  • nausea
  • vomiting
  • upper respiratory tract infection
  • abdominal pain upper
  • headache
  • supraventricular tachycardia
  • chest discomfort
  • multi-organ failure
  • pyrexia
  • renal failure
30-39:
  • nausea
  • pain
  • vomiting
  • pyrexia
  • anaemia
  • dyspnoea
  • anxiety
  • dehydration
  • hypotension
  • intervertebral disc protrusion
40-49:
  • nausea
  • vomiting
  • pain
  • pyrexia
  • dyspnoea
  • back pain
  • fatigue
  • anxiety
  • injury
  • chest pain
50-59:
  • nausea
  • pyrexia
  • dehydration
  • anxiety
  • pain
  • dyspnoea
  • anaemia
  • vomiting
  • back pain
  • emotional distress
60+:
  • nausea
  • vomiting
  • dyspnoea
  • hypotension
  • dehydration
  • diarrhoea
  • pneumonia
  • pyrexia
  • asthenia
  • anxiety

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Benadryl (diphenhydramine) is often used to treat hypersensitivity. Zofran (ondansetron) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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