Review: taking Benadryl and Zofran together


Summary

Drug interactions are reported among people who take Benadryl and Zofran together. This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 6,152 people who take the same drugs from FDA and social media, and is updated regularly.

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Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

Zofran

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (latest outcomes from Zofran 36,472 users)

On Sep, 16, 2016

6,152 people who take Benadryl, Zofran are studied.


Number of reports submitted per year:

Benadryl and Zofran drug interactions.

Drug effectiveness over time:

Benadryl:
  • < 1 month: 50.0% - (3 of 6 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)
Zofran:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 75.0% - (3 of 4 people)
  • 6 - 12 months: 66.0% - (2 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Benadryl:
  • female: 70.0% - (7 of 10 people)
  • male: 25.0% - (1 of 4 people)
Zofran:
  • female: 72.0% - (8 of 11 people)
  • male: 0.0% - (0 of 4 people)

Drug effectiveness by age:

Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 66.0% - (2 of 3 people)
  • 60+: 0.0% - (0 of 1 people)
Zofran:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 66.0% - (2 of 3 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • febrile neutropenia
  • dyspnoea
  • nausea
  • hypotension
  • pyrexia
  • vomiting
  • dehydration
  • pneumonia
  • diarrhoea
  • hyponatraemia
1 - 6 months:
  • febrile neutropenia
  • hypotension
  • sepsis
  • dehydration
  • nausea
  • acute respiratory failure
  • haemorrhage intracranial
  • failure to thrive
  • respiratory failure
  • pyrexia
6 - 12 months:
  • constipation
  • urinary tract infection
  • nausea
  • hyponatraemia
  • confusional state
  • pain
  • asthenia
  • dyspnoea
  • abdominal pain
  • anxiety
1 - 2 years:
  • osteonecrosis
  • tooth extraction
  • jaw disorder
  • bone disorder
  • exostosis
  • angioedema
  • arthralgia
  • aspartate aminotransferase increased
  • asthenia
  • balance disorder
2 - 5 years:
  • constipation
  • headache
  • nausea
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • cognitive deterioration
  • depression
5 - 10 years:
  • drug ineffective
  • vomiting
  • burning eyes
  • adverse drug reaction
  • blood potassium decreased
  • constipation
  • drug administration error
10+ years:
  • cellulitis
  • haematoma
  • pyrexia
  • sepsis
  • subdural haematoma
not specified:
  • nausea
  • vomiting
  • fatigue
  • pain
  • dyspnoea
  • pyrexia
  • diarrhoea
  • anxiety
  • anaemia
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • vomiting
  • pain
  • dyspnoea
  • fatigue
  • pyrexia
  • anxiety
  • diarrhoea
  • headache
  • anaemia
male:
  • nausea
  • pyrexia
  • fatigue
  • vomiting
  • dehydration
  • diarrhoea
  • pneumonia
  • dyspnoea
  • death
  • hypotension

Most common drug interactions by age *:

0-1:
  • constipation
  • tachycardia
  • tachypnoea
  • diarrhoea
  • vomiting
  • hypernatraemia
  • hypoxia
  • pyrexia
  • histiocytosis haematophagic
  • sleep apnoea syndrome
2-9:
  • vomiting
  • febrile neutropenia
  • diarrhoea
  • pyrexia
  • nausea
  • dehydration
  • mucosal inflammation
  • hypokalaemia
  • thrombocytopenia
  • hyponatraemia
10-19:
  • hypotension
  • nausea
  • vomiting
  • pyrexia
  • blood bilirubin increased
  • headache
  • crohn's disease
  • dehydration
  • hypokalaemia
  • febrile neutropenia
20-29:
  • nausea
  • pain
  • headache
  • pyrexia
  • vomiting
  • back pain
  • anxiety
  • diarrhoea
  • dyspnoea
  • abdominal pain upper
30-39:
  • nausea
  • pain
  • vomiting
  • pyrexia
  • dyspnoea
  • fatigue
  • anaemia
  • headache
  • abdominal pain
  • anxiety
40-49:
  • nausea
  • vomiting
  • pain
  • pyrexia
  • dyspnoea
  • fatigue
  • back pain
  • chest pain
  • diarrhoea
  • anxiety
50-59:
  • nausea
  • dyspnoea
  • fatigue
  • pyrexia
  • pain
  • vomiting
  • dehydration
  • headache
  • anxiety
  • pneumonia
60+:
  • nausea
  • dyspnoea
  • fatigue
  • diarrhoea
  • vomiting
  • pneumonia
  • pyrexia
  • asthenia
  • dehydration
  • hypotension

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Zofran (ondansetron hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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