Review: taking Bisoprolol fumarate and Spironolactone together


Summary

Drug interactions are reported among people who take Bisoprolol fumarate and Spironolactone together. This review analyzes the effectiveness and drug interactions between Bisoprolol fumarate and Spironolactone. It is created by eHealthMe based on reports of 1,532 people who take the same drugs from FDA and social media, and is updated regularly.

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Bisoprolol Fumarate

Bisoprolol fumarate has active ingredients of bisoprolol fumarate. It is often used in high blood pressure. (latest outcomes from Bisoprolol fumarate 14,968 users)

Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Spironolactone 25,644 users)

On Jul, 27, 2016

1,532 people who take Bisoprolol Fumarate, Spironolactone are studied.


Number of reports submitted per year:

Bisoprolol fumarate and Spironolactone drug interactions.

Drug effectiveness over time:

Bisoprolol Fumarate:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 66.0% - (6 of 9 people)
  • 5 - 10 years: 20.0% - (1 of 5 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Spironolactone:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 72.0% - (8 of 11 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 25.0% - (1 of 4 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Bisoprolol Fumarate:
  • female: 46.0% - (6 of 13 people)
  • male: 57.0% - (4 of 7 people)
Spironolactone:
  • female: 64.0% - (9 of 14 people)
  • male: 57.0% - (4 of 7 people)

Drug effectiveness by age:

Bisoprolol Fumarate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 71.0% - (5 of 7 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 30.0% - (3 of 10 people)
Spironolactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 85.0% - (6 of 7 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 36.0% - (4 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • hyperkalaemia
  • renal failure acute
  • atrioventricular block complete
  • sinus bradycardia
  • blood pressure decreased
  • renal failure
  • renal impairment
  • syncope
  • blood potassium increased
  • bradycardia
1 - 6 months:
  • hyponatraemia
  • renal failure acute
  • nausea
  • vomiting
  • dehydration
  • hyperkalaemia
  • diarrhoea
  • cardiac failure
  • cloudy cornea
  • eyes - sensitive to light
6 - 12 months:
  • hyperkalaemia
  • renal failure acute
  • circulatory collapse
  • hyponatraemia
  • anaemia
  • neutropenia
  • blood creatinine increased
  • bradycardia
  • asthenia
  • bundle branch block left
1 - 2 years:
  • syncope
  • hyperkalaemia
  • arrhythmia
  • hyperkinetic heart syndrome
  • renal failure acute
  • abdominal pain upper
  • amnesia
  • angina pectoris
  • cardiac failure
  • dehydration
2 - 5 years:
  • hyperkalaemia
  • disease progression
  • myocardial infarction
  • palpitations
  • cloudy cornea
  • dementia
  • eyes - sensitive to light
  • hyponatraemia
  • bile duct cancer
  • bradycardia
5 - 10 years:
  • decreased activity
  • dilatation ventricular
  • dizziness
  • dyspnoea
  • insomnia
  • pain exacerbated
  • shortness of breath
  • blood creatinine increased
  • blood urea increased
  • creatinine renal clearance decreased
10+ years:
  • atrial fibrillation
  • cardiac failure
  • left ventricular dysfunction
  • gastrointestinal haemorrhage
not specified:
  • renal failure acute
  • atrial fibrillation
  • vomiting
  • hyperkalaemia
  • dehydration
  • cardiac failure
  • renal failure
  • dyspnoea
  • nausea
  • pyrexia

Most common drug interactions by gender *:

female:
  • renal failure acute
  • atrial fibrillation
  • dehydration
  • nausea
  • vomiting
  • cardiac failure
  • pancreatitis
  • hyperkalaemia
  • hypertension
  • pyrexia
male:
  • hyperkalaemia
  • renal failure acute
  • dyspnoea
  • vomiting
  • renal failure
  • atrial fibrillation
  • cardiac failure
  • alanine aminotransferase increased
  • fatigue
  • international normalised ratio increased

Most common drug interactions by age *:

0-1:
  • blood creatinine increased
  • drug exposure during pregnancy
  • polyuria
  • premature baby
  • body temperature increased
  • bronchitis
  • c-reactive protein increased
  • convulsion
  • cough
  • cyanosis
10-19:
  • acute myeloid leukaemia
  • carotid artery occlusion
  • cerebrovascular accident
  • convulsion
  • hemiplegia
  • infection
  • leukopenia
  • pyrexia
  • vomiting
  • drug ineffective
20-29:
  • cardiac failure
  • rhabdomyolysis
  • arrhythmia
  • cardio-respiratory arrest
  • clonic convulsion
  • congestive cardiomyopathy
  • diabetes mellitus
  • hepatic infarction
  • hypokalaemia
  • pericardial effusion
30-39:
  • cardiac failure congestive
  • cardiac arrest
  • ejection fraction decreased
  • hypoxic-ischaemic encephalopathy
  • pneumonia
  • sepsis
  • congestive cardiomyopathy
  • diarrhoea
  • haemoglobin decreased
  • hypoventilation
40-49:
  • pancreatitis
  • hypertension
  • weight increased
  • atrial fibrillation
  • fear of eating
  • dehydration
  • nausea
  • pyrexia
  • gastrooesophageal reflux disease
  • dyspepsia
50-59:
  • hyperkalaemia
  • renal failure acute
  • international normalised ratio increased
  • renal failure
  • cardiac failure
  • diarrhoea
  • rectal haemorrhage
  • hyponatraemia
  • dehydration
  • dyspnoea
60+:
  • renal failure acute
  • hyperkalaemia
  • atrial fibrillation
  • vomiting
  • cardiac failure
  • dyspnoea
  • renal failure
  • nausea
  • bradycardia
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Bisoprolol fumarate (bisoprolol fumarate) is often used to treat high blood pressure. Spironolactone (spironolactone) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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