Review: taking Cardizem and Xarelto together


Summary

Drug interactions are reported among people who take Cardizem and Xarelto together. This review analyzes the effectiveness and drug interactions between Cardizem and Xarelto. It is created by eHealthMe based on reports of 121 people who take the same drugs from FDA and social media, and is updated regularly.

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Cardizem

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. (latest outcomes from Cardizem 16,234 users)

Xarelto

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from Xarelto 4,204 users)

On Jul, 28, 2016

121 people who take Cardizem, Xarelto are studied.


Number of reports submitted per year:

Cardizem and Xarelto drug interactions.

Drug effectiveness over time:

Cardizem:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 60.0% - (3 of 5 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 54.0% - (6 of 11 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Xarelto:
  • < 1 month: 100.0% - (2 of 2 people)
  • 1 - 6 months: 75.0% - (3 of 4 people)
  • 6 - 12 months: 60.0% - (3 of 5 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 100.0% - (5 of 5 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Cardizem:
  • female: 57.0% - (11 of 19 people)
  • male: 57.0% - (4 of 7 people)
Xarelto:
  • female: 81.0% - (13 of 16 people)
  • male: 71.0% - (5 of 7 people)

Drug effectiveness by age:

Cardizem:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 56.0% - (13 of 23 people)
Xarelto:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 80.0% - (16 of 20 people)

Most common drug interactions over time *:

< 1 month:
  • hepatic enzyme increased
  • gastritis erosive
  • balance disorder
  • decreased appetite
  • dehydration
  • hallucination
  • head injury
  • skeletal injury
  • jaundice cholestatic
  • asthenia
1 - 6 months:
  • hepatic enzyme increased
  • gastritis erosive
  • gastrointestinal haemorrhage
  • jaundice cholestatic
  • hypertension
  • abdominal pain
  • cardiac tamponade
  • chest pain
  • dyspnoea
  • hypotension
6 - 12 months:
  • gastritis erosive
  • hepatic enzyme increased
  • back pain
  • erectile dysfunction
  • alanine aminotransferase increased
  • colon cancer
  • hallucination, visual
  • hepatocellular injury
  • hepatotoxicity
  • melaena
1 - 2 years:
  • cough
  • carditis
  • lipids
  • nausea and vomiting
  • vertigo
  • abdominal pain
  • joint pain
  • muscle weakness
  • pain - back
  • short-term memory loss
2 - 5 years:
  • eustachian tube dysfunction
  • hypertension
  • multiple allergies
  • abdominal pain
  • asthenia
  • hyponatraemia
  • pruritus generalised
  • asthma
  • atrial fibrillation/flutter
  • back pain
5 - 10 years:
  • dizziness aggravated
  • sweating increased
  • tinnitus
10+ years:
  • nausea
  • hallucination, visual
not specified:
  • dyspnoea
  • gastrointestinal haemorrhage
  • anaemia
  • hepatic enzyme increased
  • epistaxis
  • haemoptysis
  • dizziness
  • asthenia
  • fatigue
  • gastritis erosive

Most common drug interactions by gender *:

female:
  • gastrointestinal haemorrhage
  • dyspnoea
  • balance disorder
  • decreased appetite
  • dehydration
  • dizziness
  • hallucination
  • head injury
  • skeletal injury
  • asthenia
male:
  • hepatic enzyme increased
  • gastritis erosive
  • dyspnoea
  • haemoptysis
  • jaundice cholestatic
  • gastrointestinal haemorrhage
  • anaemia
  • melaena
  • epistaxis
  • haematuria

Most common drug interactions by age *:

40-49:
  • arrhythmia
  • erectile dysfunction
  • fatigue
  • gastric ulcer
  • gastritis
  • gastrointestinal haemorrhage
50-59:
  • gastritis erosive
  • hepatic enzyme increased
  • jaundice cholestatic
  • abdominal pain
  • cardiac tamponade
  • chest pain
  • dyspnoea
  • gastrointestinal haemorrhage
  • hypotension
  • pericardial haemorrhage
60+:
  • dyspnoea
  • gastrointestinal haemorrhage
  • anaemia
  • epistaxis
  • asthenia
  • balance disorder
  • decreased appetite
  • dehydration
  • dizziness
  • hallucination

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cardizem (diltiazem hydrochloride) is often used to treat high blood pressure. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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