Review: taking Cardizem and Xarelto together


Summary

Drug interactions are reported among people who take Cardizem and Xarelto together. This review analyzes the effectiveness and drug interactions between Cardizem and Xarelto. It is created by eHealthMe based on reports of 1,671 people who take the same drugs from FDA and social media, and is updated regularly.

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Cardizem

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. (latest outcomes from Cardizem 20,325 users)

Xarelto

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from Xarelto 53,959 users)

On Sep, 16, 2016

1,671 people who take Cardizem, Xarelto are studied.


Number of reports submitted per year:

Cardizem and Xarelto drug interactions.

Drug effectiveness over time:

Cardizem:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 100.0% - (1 of 1 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 57.0% - (4 of 7 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Xarelto:
  • < 1 month: 100.0% - (2 of 2 people)
  • 1 - 6 months: 66.0% - (2 of 3 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Cardizem:
  • female: 53.0% - (7 of 13 people)
  • male: 50.0% - (3 of 6 people)
Xarelto:
  • female: 81.0% - (9 of 11 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Cardizem:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 50.0% - (8 of 16 people)
Xarelto:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 78.0% - (11 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • haemorrhagic anaemia
  • haematuria
  • upper gastrointestinal haemorrhage
  • epistaxis
  • haemorrhage
  • haematochezia
  • lower gastrointestinal haemorrhage
1 - 6 months:
  • gastrointestinal haemorrhage
  • anaemia
  • haemorrhagic anaemia
  • rectal haemorrhage
  • upper gastrointestinal haemorrhage
  • epistaxis
  • haemorrhage
  • pericardial haemorrhage
  • atrial fibrillation
  • haematuria
6 - 12 months:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • haemorrhagic anaemia
  • haemorrhage intracranial
  • upper gastrointestinal haemorrhage
  • haematuria
  • lower gastrointestinal haemorrhage
  • cerebrovascular accident
  • epistaxis
1 - 2 years:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • haematuria
  • anaemia
  • cerebral haemorrhage
  • haemorrhagic anaemia
  • epistaxis
  • renal haemorrhage
  • lower gastrointestinal haemorrhage
  • abdominal wall haematoma
2 - 5 years:
  • gastrointestinal haemorrhage
  • haemorrhagic anaemia
  • rectal haemorrhage
  • lower gastrointestinal haemorrhage
  • upper gastrointestinal haemorrhage
  • haemorrhoidal haemorrhage
  • iron deficiency anaemia
  • renal injury
  • gastric ulcer haemorrhage
  • hyponatraemia
5 - 10 years:
  • gastrointestinal haemorrhage
  • diverticulum intestinal haemorrhagic
  • dizziness aggravated
  • sweating increased
  • tinnitus
  • cerebral haemorrhage
  • dieulafoy's vascular malformation
  • haematuria
  • lower gastrointestinal haemorrhage
  • rectal haemorrhage
10+ years:
  • haematuria
  • nausea
  • renal failure
  • systemic inflammatory response syndrome
  • hallucination, visual
  • hypovolaemic shock
  • intestinal ischaemia
  • lactic acidosis
  • lower gastrointestinal haemorrhage
  • rectal haemorrhage
not specified:
  • gastrointestinal haemorrhage
  • anaemia
  • epistaxis
  • atrial fibrillation
  • rectal haemorrhage
  • dyspnoea
  • haematuria
  • haemorrhagic anaemia
  • fatigue
  • haemorrhage

Most common drug interactions by gender *:

female:
  • gastrointestinal haemorrhage
  • anaemia
  • haemorrhagic anaemia
  • epistaxis
  • rectal haemorrhage
  • atrial fibrillation
  • haematuria
  • fatigue
  • dizziness
  • dyspnoea
male:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • anaemia
  • epistaxis
  • upper gastrointestinal haemorrhage
  • haematuria
  • haemorrhagic anaemia
  • dyspnoea
  • atrial fibrillation
  • haemorrhage

Most common drug interactions by age *:

0-1:
  • abdominal pain
  • confusional state
  • hypotension
  • peritoneal haemorrhage
  • splenic rupture
10-19:
  • neutrophil count decreased
20-29:
  • abdominal pain
  • anxiety
  • constipation
  • disorientation
  • dizziness
  • erythema
  • feeling abnormal
  • gastrooesophageal reflux disease
  • heart rate increased
  • hypotension
30-39:
  • gastrointestinal haemorrhage
  • haemorrhage intracranial
  • iron deficiency anaemia
  • oxygen saturation decreased
  • rectal haemorrhage
  • fibrin d dimer increased
  • headache
  • anaemia
  • atrial fibrillation
  • cardiac disorder
40-49:
  • gastrointestinal haemorrhage
  • vaginal haemorrhage
  • rectal haemorrhage
  • anxiety
  • haematuria
  • anaemia
  • asthenia
  • fatigue
  • arthritis
  • blood cholesterol increased
50-59:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
  • gastritis erosive
  • hepatic enzyme increased
  • anaemia
  • pericardial haemorrhage
  • epistaxis
  • haematuria
  • atrial fibrillation
  • haemorrhagic anaemia
60+:
  • gastrointestinal haemorrhage
  • anaemia
  • haemorrhagic anaemia
  • rectal haemorrhage
  • epistaxis
  • upper gastrointestinal haemorrhage
  • haematuria
  • atrial fibrillation
  • dyspnoea
  • haemorrhage

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cardizem (diltiazem hydrochloride) is often used to treat high blood pressure. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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