Review: taking Cardizem and Xarelto together


Summary

Drug interactions are reported among people who take Cardizem and Xarelto together. This review analyzes the effectiveness and drug interactions between Cardizem and Xarelto. It is created by eHealthMe based on reports of 393 people who take the same drugs from FDA and social media, and is updated regularly.

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Cardizem

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. (latest outcomes from Cardizem 17,652 users)

Xarelto

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. (latest outcomes from Xarelto 14,768 users)

On Aug, 26, 2016

393 people who take Cardizem, Xarelto are studied.


Number of reports submitted per year:

Cardizem and Xarelto drug interactions.

Drug effectiveness over time:

Cardizem:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 100.0% - (1 of 1 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 57.0% - (4 of 7 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Xarelto:
  • < 1 month: 100.0% - (2 of 2 people)
  • 1 - 6 months: 66.0% - (2 of 3 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Cardizem:
  • female: 53.0% - (7 of 13 people)
  • male: 50.0% - (3 of 6 people)
Xarelto:
  • female: 81.0% - (9 of 11 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Cardizem:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 50.0% - (8 of 16 people)
Xarelto:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 78.0% - (11 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • hepatic enzyme increased
  • gastrointestinal haemorrhage
  • balance disorder
  • gastritis erosive
  • dizziness
  • nausea
  • asthenia
  • dehydration
  • dyspnoea
  • haemoglobin decreased
1 - 6 months:
  • gastrointestinal haemorrhage
  • hepatic enzyme increased
  • gastritis erosive
  • anaemia
  • atrial fibrillation
  • dyspnoea
  • haemorrhage
  • drug ineffective
  • haemoglobin decreased
  • international normalised ratio increased
6 - 12 months:
  • haemorrhage intracranial
  • abasia
  • dizziness
  • gastritis erosive
  • haemorrhagic anaemia
  • hepatic enzyme increased
  • melaena
  • upper gastrointestinal haemorrhage
  • gait disturbance
  • headache
1 - 2 years:
  • asthenia
  • cough
  • dizziness
  • fatigue
  • feeling abnormal
  • gastrointestinal sounds abnormal
  • haematochezia
  • local swelling
  • tenderness
  • tooth fracture
2 - 5 years:
  • eustachian tube dysfunction
  • hypertension
  • multiple allergies
  • abdominal pain
  • asthenia
  • hyponatraemia
  • pruritus generalised
  • asthma
  • atrial fibrillation/flutter
  • back pain
5 - 10 years:
  • dizziness aggravated
  • sweating increased
  • tinnitus
10+ years:
  • nausea
  • hallucination, visual
not specified:
  • gastrointestinal haemorrhage
  • dyspnoea
  • anaemia
  • dizziness
  • atrial fibrillation
  • asthenia
  • fatigue
  • haemoglobin decreased
  • international normalised ratio increased
  • blood urine present

Most common drug interactions by gender *:

female:
  • dizziness
  • gastrointestinal haemorrhage
  • asthenia
  • dyspnoea
  • anaemia
  • atrial fibrillation
  • fatigue
  • headache
  • nausea
  • haematochezia
male:
  • hepatic enzyme increased
  • gastritis erosive
  • dyspnoea
  • anaemia
  • blood urine present
  • haemoglobin decreased
  • haematuria
  • international normalised ratio increased
  • gastrointestinal haemorrhage
  • renal failure acute

Most common drug interactions by age *:

40-49:
  • anaemia
  • asthenia
  • fatigue
  • anxiety
  • blood cholesterol increased
  • blood creatinine increased
  • dizziness
  • epistaxis
  • nervousness
  • white blood cell count decreased
50-59:
  • gastritis erosive
  • hepatic enzyme increased
  • gastrointestinal haemorrhage
  • jaundice cholestatic
  • chest pain
  • deep vein thrombosis
  • abdominal pain
  • cardiac tamponade
  • dyspnoea
  • haematocrit decreased
60+:
  • gastrointestinal haemorrhage
  • dyspnoea
  • anaemia
  • dizziness
  • asthenia
  • atrial fibrillation
  • haematochezia
  • haemoglobin decreased
  • nausea
  • international normalised ratio increased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cardizem (diltiazem hydrochloride) is often used to treat high blood pressure. Xarelto (rivaroxaban) is often used to treat atrial fibrillation/flutter. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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