Review: taking Claritin and Methotrexate together


Summary

Drug interactions are reported among people who take Claritin and Methotrexate together. This review analyzes the effectiveness and drug interactions between Claritin and Methotrexate. It is created by eHealthMe based on reports of 1,403 people who take the same drugs from FDA and social media, and is updated regularly.

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Claritin

Claritin has active ingredients of loratadine. It is often used in hypersensitivity. (latest outcomes from Claritin 38,014 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

On Sep, 17, 2016

1,403 people who take Claritin, Methotrexate are studied.


Number of reports submitted per year:

Claritin and Methotrexate drug interactions.

Drug effectiveness over time:

Claritin:
  • < 1 month: 66.0% - (2 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Claritin:
  • female: 50.0% - (4 of 8 people)
  • male: 100.0% - (3 of 3 people)
Methotrexate:
  • female: 44.0% - (4 of 9 people)
  • male: 75.0% - (3 of 4 people)

Drug effectiveness by age:

Claritin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (2 of 2 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 50.0% - (3 of 6 people)
  • 60+: 100.0% - (1 of 1 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 66.0% - (2 of 3 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 50.0% - (3 of 6 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • hypotension
  • acute respiratory distress syndrome
  • pneumonitis
  • blood bilirubin increased
  • hypernatraemia
  • pneumonia respiratory syncytial viral
  • diarrhoea
  • headache
  • dehydration
  • febrile neutropenia
1 - 6 months:
  • electrocardiogram qt prolonged
  • macrocytosis
  • pancytopenia
  • psoriasis
  • rash
  • skin infection
  • vomiting
  • convulsion
  • cough
  • fatigue
6 - 12 months:
  • abdominal pain
  • electrocardiogram qt prolonged
  • oral candidiasis
  • pancreatitis acute
  • skin candida
  • stomatitis
  • abdominal distension
  • alopecia
  • arthralgia
  • arthropathy
1 - 2 years:
  • malaise
  • acute respiratory distress syndrome
  • basal cell carcinoma
  • dehydration
  • fatigue
  • hypoxia
  • myalgia
  • myoglobinuria
  • neuroleptic malignant syndrome
  • pneumonia
2 - 5 years:
  • asthenia
  • alanine aminotransferase increased
  • arthritis
  • dizziness
  • rash
  • arthralgia
  • diarrhoea
  • dry mouth
  • dyspnoea
  • lymphadenopathy
5 - 10 years:
  • acute respiratory failure
  • altered state of consciousness
  • aphasia
  • breast cancer
  • csf mononuclear cell count increased
  • death
  • feeling abnormal
  • headache
  • hypoglycaemia
  • lung disorder
10+ years:
  • hypertensive emergency
  • aortic valve incompetence
  • breathlessness
  • bronchitis
  • cardiac failure congestive
  • decreased appetite
  • diastolic dysfunction
  • fatigue - chronic
  • gout
  • herpes zoster
not specified:
  • nausea
  • drug ineffective
  • dyspnoea
  • arthralgia
  • injection site pain
  • pain
  • headache
  • fatigue
  • cough
  • vomiting

Most common drug interactions by gender *:

female:
  • nausea
  • injection site pain
  • drug ineffective
  • arthralgia
  • pain
  • dyspnoea
  • headache
  • fatigue
  • diarrhoea
  • cough
male:
  • pain
  • dyspnoea
  • nausea
  • headache
  • arthralgia
  • cough
  • drug ineffective
  • pyrexia
  • chest pain
  • back pain

Most common drug interactions by age *:

0-1:
  • bladder diverticulum
  • clostridial infection
  • palatal disorder
  • reflux nephropathy
  • renal hypertrophy
  • respiratory syncytial virus infection
  • urinary tract infection
2-9:
  • diarrhoea
  • headache
  • dyspnoea
  • nausea
  • pain
  • somnolence
  • dehydration
  • mucosal inflammation
  • bradycardia
  • cardio-respiratory arrest
10-19:
  • pneumonitis
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypotension
  • lung infection
  • febrile neutropenia
  • acute psychosis
  • arthritis
  • hypernatraemia
  • platelet count decreased
20-29:
  • pyrexia
  • deep vein thrombosis
  • epistaxis
  • headache
  • infusion related reaction
  • pulmonary embolism
  • diarrhoea
  • abdominal pain upper
  • anal abscess
  • back pain
30-39:
  • injection site pain
  • nausea
  • dizziness
  • pain
  • panic attack
  • dyspnoea
  • drug ineffective
  • erythema
  • hypersensitivity
  • hypoaesthesia
40-49:
  • arthralgia
  • injection site pain
  • headache
  • nausea
  • pain
  • drug ineffective
  • dyspnoea
  • fatigue
  • hypoaesthesia
  • pain in extremity
50-59:
  • dyspnoea
  • arthralgia
  • nausea
  • pain
  • fatigue
  • headache
  • vomiting
  • sinusitis
  • pyrexia
  • cough
60+:
  • dyspnoea
  • pneumonia
  • arthralgia
  • nausea
  • injection site pain
  • back pain
  • pain
  • oedema peripheral
  • rheumatoid arthritis
  • cough

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Claritin (loratadine) is often used to treat hypersensitivity. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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