Review: taking Claritin and Methotrexate together


Summary

Drug interactions are reported among people who take Claritin and Methotrexate together. This review analyzes the effectiveness and drug interactions between Claritin and Methotrexate. It is created by eHealthMe based on reports of 711 people who take the same drugs from FDA and social media, and is updated regularly.

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Claritin

Claritin has active ingredients of loratadine. It is often used in hypersensitivity. (latest outcomes from Claritin 21,145 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,047 users)

On Jul, 28, 2016

711 people who take Claritin, Methotrexate are studied.


Number of reports submitted per year:

Claritin and Methotrexate drug interactions.

Drug effectiveness over time:

Claritin:
  • < 1 month: 66.0% - (2 of 3 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 50.0% - (1 of 2 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Claritin:
  • female: 55.0% - (5 of 9 people)
  • male: 100.0% - (3 of 3 people)
Methotrexate:
  • female: 40.0% - (4 of 10 people)
  • male: 75.0% - (3 of 4 people)

Drug effectiveness by age:

Claritin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (2 of 2 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 57.0% - (4 of 7 people)
  • 60+: 100.0% - (1 of 1 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 66.0% - (2 of 3 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 42.0% - (3 of 7 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • hypotension
  • acute respiratory distress syndrome
  • pneumonitis
  • blood bilirubin increased
  • hypernatraemia
  • pneumonia respiratory syncytial viral
  • blood sodium increased
  • lung infection
  • bradycardia
  • cardio-respiratory arrest
1 - 6 months:
  • macrocytosis
  • pancytopenia
  • psoriasis
  • rash
  • skin infection
  • convulsion
  • leukopenia
  • upper respiratory tract infection
  • urticaria
  • cough
6 - 12 months:
  • pancreatitis acute
  • abdominal distension
  • arthralgia
  • arthropathy
  • asthenia
  • bursitis
  • dyspepsia
  • ear infection
  • fatigue
  • flatulence
1 - 2 years:
  • malaise
  • acute respiratory distress syndrome
  • basal cell carcinoma
  • dehydration
  • fatigue
  • hypoxia
  • myalgia
  • myoglobinuria
  • neuroleptic malignant syndrome
  • pneumonia
2 - 5 years:
  • alanine aminotransferase increased
  • arthritis
  • asthenia
  • arthralgia
  • diarrhoea
  • dizziness
  • dry mouth
  • lymphadenopathy
  • musculoskeletal stiffness
  • rash
5 - 10 years:
  • altered state of consciousness
  • aphasia
  • csf mononuclear cell count increased
  • feeling abnormal
  • headache
  • hypoglycaemia
  • memory impairment
  • motor dysfunction
  • rheumatoid lung
  • alveolitis allergic
10+ years:
  • hypertensive emergency
  • aortic valve incompetence
  • breathlessness
  • bronchitis
  • cardiac failure congestive
  • decreased appetite
  • diastolic dysfunction
  • fatigue - chronic
  • gout
  • herpes zoster
not specified:
  • nausea
  • dyspnoea
  • arthralgia
  • pain
  • cough
  • oedema peripheral
  • headache
  • pyrexia
  • drug ineffective
  • vomiting

Most common drug interactions by gender *:

female:
  • nausea
  • arthralgia
  • dyspnoea
  • oedema peripheral
  • fatigue
  • hypoaesthesia
  • pain
  • cough
  • vomiting
  • pyrexia
male:
  • dyspnoea
  • cough
  • headache
  • nausea
  • pain
  • oxygen saturation decreased
  • somnolence
  • coma
  • pneumonia
  • pyrexia

Most common drug interactions by age *:

0-1:
  • bladder diverticulum
  • clostridial infection
  • palatal disorder
  • reflux nephropathy
  • renal hypertrophy
  • respiratory syncytial virus infection
  • urinary tract infection
2-9:
  • diarrhoea
  • dyspnoea
  • headache
  • nausea
  • somnolence
  • bradycardia
  • cardio-respiratory arrest
  • coma
  • cough
  • epistaxis
10-19:
  • pneumonitis
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypotension
  • hypernatraemia
  • pneumonia respiratory syncytial viral
  • acanthosis
  • blood sodium increased
  • lung infection
  • convulsion
20-29:
  • deep vein thrombosis
  • epistaxis
  • pulmonary embolism
  • haemorrhage
  • pancytopenia
  • purpura
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • bleeding time prolonged
  • bone marrow toxicity
30-39:
  • alanine aminotransferase increased
  • injection site pain
  • erythema
  • aphonia
  • pain
  • drug ineffective
  • headache
  • hypersensitivity
  • hypothyroidism
  • infusion related reaction
40-49:
  • arthralgia
  • nausea
  • drug ineffective
  • headache
  • hypoaesthesia
  • gait disturbance
  • injection site erythema
  • injection site pain
  • pruritus
  • paraesthesia
50-59:
  • arthralgia
  • nausea
  • dyspnoea
  • hypoaesthesia
  • asthenia
  • oedema peripheral
  • pain in extremity
  • abdominal pain
  • cough
  • injury
60+:
  • dyspnoea
  • nausea
  • back pain
  • cough
  • pneumonia
  • oedema peripheral
  • pyrexia
  • fatigue
  • arthralgia
  • dry mouth

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Claritin (loratadine) is often used to treat hypersensitivity. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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