Review: taking Clonidine and Benadryl together


Summary

Drug interactions are reported among people who take Clonidine and Benadryl together. This review analyzes the effectiveness and drug interactions between Clonidine and Benadryl. It is created by eHealthMe based on reports of 1,159 people who take the same drugs from FDA and social media, and is updated regularly.

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Clonidine

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. (latest outcomes from Clonidine 29,482 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,260 users)

On Sep, 16, 2016

1,159 people who take Clonidine, Benadryl are studied.


Number of reports submitted per year:

Clonidine and Benadryl drug interactions.

Drug effectiveness over time:

Clonidine:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 66.0% - (2 of 3 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Clonidine:
  • female: 50.0% - (4 of 8 people)
  • male: 30.0% - (3 of 10 people)
Benadryl:
  • female: 37.0% - (3 of 8 people)
  • male: 12.0% - (1 of 8 people)

Drug effectiveness by age:

Clonidine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 3 people)
  • 10-19: 60.0% - (3 of 5 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 25.0% - (1 of 4 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 4 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 0.0% - (0 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • gastroenteritis
  • skin ulcer
  • pneumonia
  • renal failure acute
  • impaired healing
  • mental status changes
  • renal tubular necrosis
  • sepsis syndrome
  • syncope
  • blood alkaline phosphatase increased
1 - 6 months:
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypernatraemia
  • hypotension
  • pneumonia respiratory syncytial viral
  • pneumonitis
  • nausea
  • abdominal wall haematoma
  • anaemia
  • cardiac failure congestive
6 - 12 months:
  • cardiac failure congestive
  • dyspnoea
  • atrial fibrillation
  • blood glucose decreased
  • blood glucose increased
  • delirium
  • diabetes mellitus
  • disability
  • erythema
  • fabry's disease
1 - 2 years:
  • hyponatraemia
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • cognitive deterioration
  • constipation
  • depression
  • diarrhea
2 - 5 years:
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • depression
  • headache
  • lethargy
  • nausea
  • pain of skin
5 - 10 years:
  • vertigo positional
  • hallucination
  • menopausal symptoms
  • nipple discharge - abnormal
  • short-term memory loss
not specified:
  • nausea
  • pain
  • dyspnoea
  • vomiting
  • pyrexia
  • anxiety
  • fatigue
  • arthralgia
  • asthenia
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • pain
  • vomiting
  • fatigue
  • headache
  • depression
  • oedema peripheral
  • asthenia
  • arthralgia
male:
  • pain
  • anaemia
  • pyrexia
  • nausea
  • anxiety
  • vomiting
  • dyspnoea
  • diarrhoea
  • arthralgia
  • asthenia

Most common drug interactions by age *:

0-1:
  • nasal congestion
  • adenovirus infection
  • aggression
  • bone marrow transplant rejection
  • convulsion
  • cough
  • multi-organ failure
  • renal failure
  • respiratory failure
  • urinary glycosaminoglycans increased
2-9:
  • enuresis
  • vomiting
  • cough
  • influenza
  • eyelid ptosis
  • astigmatism
  • arthralgia
  • asthenia
  • hypertension
  • aggression
10-19:
  • weight increased
  • agitation
  • hypotension
  • compartment syndrome
  • drug administration error
  • extremity necrosis
  • neuroleptic malignant syndrome
  • rhabdomyolysis
  • aggression
  • pneumonia
20-29:
  • gastroenteritis
  • nausea
  • vomiting
  • cardiac failure congestive
  • urinary tract infection
  • bronchitis
  • abdominal pain upper
  • hypertension
  • abdominal pain
  • cholecystitis
30-39:
  • nausea
  • diabetes mellitus
  • headache
  • pain
  • vomiting
  • abdominal pain
  • dizziness
  • anxiety
  • depression
  • diarrhoea
40-49:
  • nausea
  • depression
  • pain
  • anxiety
  • chest pain
  • headache
  • arthralgia
  • fall
  • pyrexia
  • dyspnoea
50-59:
  • nausea
  • hypertension
  • completed suicide
  • fatigue
  • asthenia
  • depression
  • pyrexia
  • vomiting
  • renal failure acute
  • oedema peripheral
60+:
  • dyspnoea
  • anxiety
  • nausea
  • pain
  • anaemia
  • pyrexia
  • asthenia
  • fall
  • pleural effusion
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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