Review: taking Clonidine and Benadryl together


Summary

Drug interactions are reported among people who take Clonidine and Benadryl together. This review analyzes the effectiveness and drug interactions between Clonidine and Benadryl. It is created by eHealthMe based on reports of 743 people who take the same drugs from FDA and social media, and is updated regularly.

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Clonidine

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. (latest outcomes from Clonidine 23,226 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

743 people who take Clonidine, Benadryl are studied.


Number of reports submitted per year:

Clonidine and Benadryl drug interactions.

Drug effectiveness over time:

Clonidine:
  • < 1 month: 100.0% - (4 of 4 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 2 people)
  • 1 - 2 years: 100.0% - (4 of 4 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 14.0% - (1 of 7 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 4 people)
  • 2 - 5 years: 33.0% - (2 of 6 people)
  • 5 - 10 years: 0.0% - (0 of 6 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Clonidine:
  • female: 71.0% - (10 of 14 people)
  • male: 21.0% - (3 of 14 people)
Benadryl:
  • female: 21.0% - (3 of 14 people)
  • male: 8.0% - (1 of 12 people)

Drug effectiveness by age:

Clonidine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 3 people)
  • 10-19: 60.0% - (3 of 5 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 100.0% - (5 of 5 people)
  • 60+: 36.0% - (4 of 11 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 4 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 20.0% - (1 of 5 people)
  • 60+: 0.0% - (0 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • renal failure acute
  • mental status changes
  • renal tubular necrosis
  • sepsis syndrome
  • syncope
  • vomiting
  • abscess
  • blood creatinine increased
  • constipation
  • dyspnoea
1 - 6 months:
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypernatraemia
  • hypotension
  • pneumonia respiratory syncytial viral
  • pneumonitis
  • dehydration
  • failure to thrive
  • febrile neutropenia
  • nausea
6 - 12 months:
  • cardiac failure congestive
  • delirium
  • erythema
  • fabry's disease
  • foot fracture
  • infusion related reaction
  • irritability
  • lymphoedema
  • pain
  • renal impairment
1 - 2 years:
  • hyponatraemia
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • cognitive deterioration
  • constipation
  • depression
  • diarrhea
2 - 5 years:
  • chronic sinusitis
  • cognitive deterioration
  • constipation
  • depression
  • headache
  • pain of skin
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
5 - 10 years:
  • vertigo positional
  • menopausal symptoms
  • nipple discharge - abnormal
  • short-term memory loss
not specified:
  • nausea
  • dyspnoea
  • pain
  • pyrexia
  • asthenia
  • anxiety
  • vomiting
  • headache
  • arthralgia
  • chest pain

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • chest pain
  • pain
  • headache
  • vomiting
  • fatigue
  • oedema peripheral
  • pyrexia
  • insomnia
male:
  • pyrexia
  • pain
  • anxiety
  • arthralgia
  • gait disturbance
  • nausea
  • anaemia
  • asthenia
  • dyspnoea
  • vomiting

Most common drug interactions by age *:

0-1:
  • aggression
  • convulsion
  • agitation
  • application site discolouration
  • foaming at mouth
  • tardive dyskinesia
2-9:
  • vomiting
  • cough
  • enuresis
  • eyelid ptosis
  • hypertension
  • blood pressure decreased
  • pyrexia
  • somnolence
  • speech disorder
  • abdominal distension
10-19:
  • hypotension
  • weight increased
  • compartment syndrome
  • drug administration error
  • extremity necrosis
  • neuroleptic malignant syndrome
  • rhabdomyolysis
  • aggression
  • agitation
  • pneumonia
20-29:
  • nausea
  • bronchitis
  • vomiting
  • cardiac failure congestive
  • insomnia
  • sinusitis
  • urinary tract infection
  • abdominal pain
  • abdominal pain upper
  • atrial fibrillation
30-39:
  • diabetes mellitus
  • pain
  • abdominal pain
  • headache
  • nausea
  • dyspnoea
  • anxiety
  • arteriosclerosis
  • depression
  • diarrhoea
40-49:
  • depression
  • anxiety
  • pain
  • nausea
  • fall
  • chest pain
  • arthralgia
  • muscle spasms
  • pyrexia
  • dizziness
50-59:
  • nausea
  • depression
  • asthenia
  • pyrexia
  • fatigue
  • renal failure acute
  • cardiac failure congestive
  • hypertension
  • oedema peripheral
  • sepsis
60+:
  • dyspnoea
  • pyrexia
  • anaemia
  • pain
  • renal failure chronic
  • nausea
  • anxiety
  • asthenia
  • pleural effusion
  • chest pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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