Review: taking Coumadin and Centrum silver together


Summary

Drug interactions are reported among people who take Coumadin and Centrum silver together. This review analyzes the effectiveness and drug interactions between Coumadin and Centrum silver. It is created by eHealthMe based on reports of 7,041 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,806 users)

Centrum Silver

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. (latest outcomes from Centrum silver 9,651 users)

On Sep, 17, 2016

7,041 people who take Coumadin, Centrum Silver are studied.


Number of reports submitted per year:

Coumadin and Centrum silver drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 33.0% - (2 of 6 people)
  • 1 - 6 months: 22.0% - (2 of 9 people)
  • 6 - 12 months: 100.0% - (7 of 7 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 100.0% - (11 of 11 people)
  • 10+ years: 92.0% - (12 of 13 people)
  • not specified: 100.0% - (2 of 2 people)
Centrum Silver:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 25.0% - (1 of 4 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 42.0% - (3 of 7 people)
  • 5 - 10 years: 8.0% - (1 of 12 people)
  • 10+ years: 50.0% - (8 of 16 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 67.0% - (23 of 34 people)
  • male: 72.0% - (18 of 25 people)
Centrum Silver:
  • female: 32.0% - (9 of 28 people)
  • male: 31.0% - (7 of 22 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 100.0% - (5 of 5 people)
  • 50-59: 71.0% - (15 of 21 people)
  • 60+: 64.0% - (20 of 31 people)
Centrum Silver:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 25.0% - (1 of 4 people)
  • 50-59: 35.0% - (6 of 17 people)
  • 60+: 29.0% - (8 of 27 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • nausea
  • abdominal pain
  • hypertension
  • polycythaemia
  • anaemia
  • asthenia
  • diarrhoea
  • atrial fibrillation
  • urinary tract infection
1 - 6 months:
  • gastrointestinal haemorrhage
  • contusion
  • international normalised ratio increased
  • white blood cell count increased
  • haemoglobin decreased
  • arthralgia
  • aspartate aminotransferase increased
  • lethargy
  • urinary tract infection
  • abdominal pain
6 - 12 months:
  • dehydration
  • lower gastrointestinal haemorrhage
  • mucosal inflammation
  • death
  • international normalised ratio increased
  • anaemia
  • anxiety
  • asthenia
  • blood urea increased
  • coagulopathy
1 - 2 years:
  • anaemia
  • haemorrhage
  • hoarseness or changing voice
  • abdominal pain
  • chest pain
  • confusional state
  • contusion
  • epistaxis
  • hypotension
  • international normalised ratio increased
2 - 5 years:
  • shortness of breath
  • diarrhoea
  • international normalised ratio increased
  • low blood sugar
  • muscle weakness
  • myelodysplastic syndrome
  • constipation
  • syncope
  • abdominal pain aggravated
  • anaemia
5 - 10 years:
  • nephrogenic systemic fibrosis
  • pain
  • anxiety
  • emotional distress
  • skin hyperpigmentation
  • skin hypertrophy
  • skin induration
  • skin tightness
  • musculoskeletal stiffness
  • anhedonia
10+ years:
  • international normalised ratio increased
  • dizziness
  • shortness of breath
  • low blood sugar
  • muscle weakness
  • atrial fibrillation
  • chest pain
  • coagulopathy
  • confusional state
  • depression
not specified:
  • pain
  • fatigue
  • dyspnoea
  • nausea
  • asthenia
  • anxiety
  • anaemia
  • fall
  • atrial fibrillation
  • oedema peripheral

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • fatigue
  • dyspnoea
  • asthenia
  • fall
  • diarrhoea
  • pain in extremity
  • atrial fibrillation
  • anaemia
male:
  • pain
  • fatigue
  • dyspnoea
  • anxiety
  • nausea
  • anaemia
  • pneumonia
  • atrial fibrillation
  • oedema peripheral
  • asthenia

Most common drug interactions by age *:

0-1:
  • drug exposure via breast milk
  • hypothyroidism
2-9:
  • abdominal pain
  • actinic keratosis
  • anaemia
  • appendicitis
  • bone disorder
  • cardiac failure congestive
  • cardiac murmur
  • cardiomyopathy
  • carpal tunnel syndrome
  • cerebral calcification
10-19:
  • headache
  • nausea
  • atrial fibrillation
  • cardiac failure congestive
  • drug hypersensitivity
  • ill-defined disorder
  • pyrexia
  • vomiting
  • abdominal pain
  • asthenia
20-29:
  • fall
  • bronchitis
  • fatigue
  • cardiac failure congestive
  • insomnia
  • pain
  • cholecystitis
  • flank pain
  • influenza like illness
  • sinusitis
30-39:
  • pain
  • fatigue
  • anxiety
  • pain in extremity
  • gait disturbance
  • anhedonia
  • malaise
  • myalgia
  • gastrooesophageal reflux disease
  • cough
40-49:
  • pain
  • dyspnoea
  • depression
  • oedema peripheral
  • fatigue
  • pain in extremity
  • vision blurred
  • cough
  • cataract
  • nausea
50-59:
  • pain
  • anxiety
  • bone disorder
  • osteonecrosis of jaw
  • fatigue
  • arthralgia
  • nausea
  • anaemia
  • infection
  • impaired healing
60+:
  • dyspnoea
  • fatigue
  • nausea
  • asthenia
  • pain
  • atrial fibrillation
  • diarrhoea
  • fall
  • dizziness
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) is often used to treat vitamin supplementation. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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