Review: taking Coumadin and Loperamide hydrochloride together


Summary

Drug interactions are reported among people who take Coumadin and Loperamide hydrochloride together. This review analyzes the effectiveness and drug interactions between Coumadin and Loperamide hydrochloride. It is created by eHealthMe based on reports of 1,298 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 73,270 users)

Loperamide Hydrochloride

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. (latest outcomes from Loperamide hydrochloride 2,151 users)

On Jul, 22, 2016

1,298 people who take Coumadin, Loperamide Hydrochloride are studied.


Number of reports submitted per year:

Coumadin and Loperamide hydrochloride drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 40.0% - (2 of 5 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 100.0% - (3 of 3 people)
  • 2 - 5 years: 42.0% - (3 of 7 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 50.0% - (3 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Loperamide Hydrochloride:
  • < 1 month: 30.0% - (3 of 10 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 71.0% - (5 of 7 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 46.0% - (7 of 15 people)
  • male: 63.0% - (7 of 11 people)
Loperamide Hydrochloride:
  • female: 46.0% - (6 of 13 people)
  • male: 54.0% - (6 of 11 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 20.0% - (2 of 10 people)
  • 60+: 75.0% - (9 of 12 people)
Loperamide Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 50.0% - (5 of 10 people)
  • 60+: 63.0% - (7 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • anaemia
  • vomiting
  • dehydration
  • nausea
  • diarrhoea
  • international normalised ratio increased
  • abdominal pain
  • thrombocytopenia
  • hypotension
  • febrile neutropenia
1 - 6 months:
  • platelet count decreased
  • ascites
  • diarrhoea
  • nephrotic syndrome
  • anaemia
  • renal failure chronic
  • asthenia
  • myositis
  • neuropathy peripheral
  • rash
6 - 12 months:
  • gastrointestinal haemorrhage
  • dehydration
  • diarrhoea
  • febrile neutropenia
  • anaemia
  • blood sodium decreased
  • haematemesis
  • hypotension
  • fatigue
  • international normalised ratio increased
1 - 2 years:
  • diarrhoea
  • duodenal ulcer
  • duodenal ulcer haemorrhage
  • fall
  • haematemesis
  • haemoglobin decreased
  • hypomagnesaemia
  • international normalised ratio increased
  • nausea
  • serotonin syndrome
2 - 5 years:
  • diarrhoea
  • cardiac failure congestive
  • fall
  • hot flushes
  • nausea
  • serotonin syndrome
  • adverse drug reaction
  • adverse reaction
  • atrial fibrillation
  • blood glucose increased
5 - 10 years:
  • thrombosis
  • malignant melanoma
  • oesophageal varices haemorrhage
  • ventricular tachycardia
  • cystitis
  • sudden death
10+ years:
  • depression aggravated
  • diarrhoea
  • elevated mood
  • international normalised ratio increased
  • ringing in the ears
not specified:
  • diarrhoea
  • pain
  • nausea
  • anxiety
  • oedema peripheral
  • dyspnoea
  • international normalised ratio increased
  • anaemia
  • asthenia
  • atrial fibrillation

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • diarrhoea
  • oedema peripheral
  • anxiety
  • anaemia
  • asthenia
  • dyspnoea
  • atrial fibrillation
  • injury
male:
  • diarrhoea
  • international normalised ratio increased
  • pyrexia
  • nausea
  • deep vein thrombosis
  • pain
  • anxiety
  • gastrointestinal haemorrhage
  • vomiting
  • pneumonia

Most common drug interactions by age *:

0-1:
  • contusion
  • international normalised ratio increased
  • neutropenia
  • petechiae
  • supraventricular extrasystoles
  • drug eruption
  • mitral valve disease
  • pyrexia
  • rash
  • rash papular
10-19:
  • atelectasis
  • blood sodium decreased
  • diabetes mellitus
  • electrolyte imbalance
  • hypercoagulation
  • hyperlipidaemia
  • hypoalbuminaemia
  • leukocytosis
  • nephrotic syndrome
20-29:
  • nausea
  • pulmonary hypertension
  • hypotension
  • vomiting
  • drug ineffective
  • catheter related complication
  • diarrhoea
  • pyrexia
  • rash
  • abscess
30-39:
  • pulmonary embolism
  • deep vein thrombosis
  • diabetes mellitus
  • ketosis
  • nausea
  • oedema peripheral
  • diarrhoea
  • thrombosis
  • cellulitis
  • device related infection
40-49:
  • diarrhoea
  • international normalised ratio increased
  • rash
  • haematoma
  • contusion
  • oedema
  • swelling
  • pain
  • dyspnoea
  • pyrexia
50-59:
  • pain
  • anxiety
  • oedema peripheral
  • anaemia
  • diarrhoea
  • pain in extremity
  • osteoarthritis
  • nausea
  • depression
  • bone disorder
60+:
  • diarrhoea
  • nausea
  • international normalised ratio increased
  • asthenia
  • vomiting
  • atrial fibrillation
  • anxiety
  • hypotension
  • dyspnoea
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Loperamide hydrochloride (loperamide hydrochloride) is often used to treat diarrhea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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