Review: taking Coumadin and Metformin together


Summary

Drug interactions are reported among people who take Coumadin and Metformin together. This review analyzes the effectiveness and drug interactions between Coumadin and Metformin. It is created by eHealthMe based on reports of 7,139 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 80,735 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 117,555 users)

On Aug, 19, 2016

7,139 people who take Coumadin, Metformin are studied.


Number of reports submitted per year:

Coumadin and Metformin drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 30.0% - (6 of 20 people)
  • 6 - 12 months: 62.0% - (5 of 8 people)
  • 1 - 2 years: 60.0% - (12 of 20 people)
  • 2 - 5 years: 61.0% - (11 of 18 people)
  • 5 - 10 years: 73.0% - (14 of 19 people)
  • 10+ years: 73.0% - (14 of 19 people)
  • not specified: 0.0% - (0 of 1 people)
Metformin:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 50.0% - (5 of 10 people)
  • 6 - 12 months: 44.0% - (4 of 9 people)
  • 1 - 2 years: 35.0% - (6 of 17 people)
  • 2 - 5 years: 42.0% - (9 of 21 people)
  • 5 - 10 years: 55.0% - (19 of 34 people)
  • 10+ years: 57.0% - (8 of 14 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 51.0% - (17 of 33 people)
  • male: 60.0% - (45 of 74 people)
Metformin:
  • female: 44.0% - (16 of 36 people)
  • male: 47.0% - (35 of 73 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 0.0% - (0 of 5 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 63.0% - (14 of 22 people)
  • 60+: 61.0% - (45 of 73 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 60.0% - (3 of 5 people)
  • 40-49: 42.0% - (3 of 7 people)
  • 50-59: 50.0% - (12 of 24 people)
  • 60+: 45.0% - (33 of 72 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • dyspnoea
  • atrial fibrillation
  • thrombocytopenia
  • nausea
  • renal failure acute
  • abdominal pain
  • diarrhoea
  • anaemia
  • bradycardia
1 - 6 months:
  • confusional state
  • cerebral infarction
  • sedation
  • pyrexia
  • fatigue
  • headache
  • vomiting
  • international normalised ratio increased
  • bradycardia
  • amnesia
6 - 12 months:
  • dizziness
  • renal failure acute
  • aortic valve sclerosis
  • atrial fibrillation
  • atrial flutter
  • cough
  • diabetic retinopathy
  • dyspnoea
  • flushing
  • myalgia
1 - 2 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • anaemia
  • deep vein thrombosis
  • dyspnoea
  • pain
  • pulmonary embolism
  • international normalised ratio increased
2 - 5 years:
  • atherosclerosis
  • hypertension
  • ischaemic stroke
  • type 2 diabetes mellitus
  • anaemia
  • international normalised ratio increased
  • lactic acidosis
  • myocardial infarction
  • renal failure acute
  • atrial fibrillation
5 - 10 years:
  • depression
  • dizziness
  • cardiac failure congestive
  • anaemia
  • cerebrovascular accident
  • weakness
  • coronary artery disease
  • fatigue
  • headache
  • muscle twitching
10+ years:
  • renal failure acute
  • bradycardia
  • mental status changes
  • anuria
  • cardiogenic shock
  • coagulopathy
  • coma
  • lactic acidosis
  • metabolic acidosis
  • somnolence
not specified:
  • dyspnoea
  • atrial fibrillation
  • nausea
  • pain
  • international normalised ratio increased
  • cardiac failure congestive
  • fatigue
  • dizziness
  • asthenia
  • anxiety

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • international normalised ratio increased
  • pain
  • atrial fibrillation
  • fatigue
  • cardiac failure congestive
  • fall
  • anxiety
  • asthenia
male:
  • dyspnoea
  • atrial fibrillation
  • cardiac failure congestive
  • international normalised ratio increased
  • fatigue
  • pain
  • dizziness
  • nausea
  • renal failure acute
  • asthenia

Most common drug interactions by age *:

0-1:
  • muscular weakness
  • tremor
  • atrial fibrillation
  • cerebrovascular accident
  • neoplasm malignant
  • thrombophlebitis superficial
10-19:
  • deep vein thrombosis
  • pain
  • pain in extremity
  • pulmonary embolism
  • activities of daily living impaired
  • chest pain
  • cholelithiasis
  • hypercoagulation
  • injury
  • oedema peripheral
20-29:
  • deep vein thrombosis
  • pulmonary embolism
  • pain
  • anxiety
  • cholecystitis chronic
  • injury
  • mental disorder
  • pain in extremity
  • dyspnoea
  • abdominal pain
30-39:
  • pain
  • anxiety
  • type 2 diabetes mellitus
  • malaise
  • urinary tract infection
  • deep vein thrombosis
  • pulmonary embolism
  • sinus tachycardia
  • convulsion
  • dysphagia
40-49:
  • fatigue
  • dyspnoea
  • pain
  • nausea
  • myocardial infarction
  • diabetes mellitus
  • vomiting
  • weight decreased
  • anxiety
  • international normalised ratio increased
50-59:
  • atrial fibrillation
  • cardiac failure congestive
  • nausea
  • dyspnoea
  • myocardial infarction
  • oedema peripheral
  • pain
  • international normalised ratio increased
  • renal failure acute
  • diarrhoea
60+:
  • international normalised ratio increased
  • atrial fibrillation
  • dyspnoea
  • nausea
  • cardiac failure congestive
  • fatigue
  • dizziness
  • renal failure acute
  • fall
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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