Review: taking Coumadin and Metformin together


Summary

Drug interactions are reported among people who take Coumadin and Metformin together. This review analyzes the effectiveness and drug interactions between Coumadin and Metformin. It is created by eHealthMe based on reports of 9,170 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,806 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,674 users)

On Sep, 17, 2016

9,170 people who take Coumadin, Metformin are studied.


Number of reports submitted per year:

Coumadin and Metformin drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 30.0% - (6 of 20 people)
  • 6 - 12 months: 62.0% - (5 of 8 people)
  • 1 - 2 years: 60.0% - (12 of 20 people)
  • 2 - 5 years: 61.0% - (11 of 18 people)
  • 5 - 10 years: 73.0% - (14 of 19 people)
  • 10+ years: 73.0% - (14 of 19 people)
  • not specified: 0.0% - (0 of 1 people)
Metformin:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 50.0% - (5 of 10 people)
  • 6 - 12 months: 44.0% - (4 of 9 people)
  • 1 - 2 years: 35.0% - (6 of 17 people)
  • 2 - 5 years: 42.0% - (9 of 21 people)
  • 5 - 10 years: 55.0% - (19 of 34 people)
  • 10+ years: 57.0% - (8 of 14 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 51.0% - (17 of 33 people)
  • male: 60.0% - (45 of 74 people)
Metformin:
  • female: 44.0% - (16 of 36 people)
  • male: 47.0% - (35 of 73 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 0.0% - (0 of 5 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 63.0% - (14 of 22 people)
  • 60+: 61.0% - (45 of 73 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 60.0% - (3 of 5 people)
  • 40-49: 42.0% - (3 of 7 people)
  • 50-59: 50.0% - (12 of 24 people)
  • 60+: 45.0% - (33 of 72 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • dyspnoea
  • blood creatine phosphokinase increased
  • muscular weakness
  • myositis
  • anaemia
  • atrial fibrillation
  • diarrhoea
  • nausea
  • myocardial infarction
1 - 6 months:
  • confusional state
  • cerebral infarction
  • sedation
  • international normalised ratio increased
  • headache
  • pyrexia
  • fatigue
  • vomiting
  • bradycardia
  • amnesia
6 - 12 months:
  • dizziness
  • atrial fibrillation
  • renal failure acute
  • metabolic acidosis
  • aortic valve sclerosis
  • atrial flutter
  • cough
  • diabetic retinopathy
  • dyspnoea
  • flushing
1 - 2 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • lactic acidosis
  • renal failure
  • anaemia
  • pain
  • dyspnoea
  • deep vein thrombosis
2 - 5 years:
  • atherosclerosis
  • hypertension
  • ischaemic stroke
  • type 2 diabetes mellitus
  • international normalised ratio increased
  • anaemia
  • lactic acidosis
  • myocardial infarction
  • renal failure acute
  • atrial fibrillation
5 - 10 years:
  • depression
  • dizziness
  • anaemia
  • cardiac failure congestive
  • cerebrovascular accident
  • fatigue
  • thrombocytopenia
  • weakness
  • chest pain
  • coronary artery disease
10+ years:
  • renal failure acute
  • bradycardia
  • mental status changes
  • anuria
  • cardiogenic shock
  • coagulopathy
  • coma
  • international normalised ratio increased
  • lactic acidosis
  • metabolic acidosis
not specified:
  • dyspnoea
  • atrial fibrillation
  • nausea
  • international normalised ratio increased
  • fatigue
  • pain
  • cardiac failure congestive
  • dizziness
  • asthenia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • dyspnoea
  • nausea
  • international normalised ratio increased
  • fatigue
  • pain
  • atrial fibrillation
  • fall
  • asthenia
  • cardiac failure congestive
  • dizziness
male:
  • dyspnoea
  • atrial fibrillation
  • international normalised ratio increased
  • cardiac failure congestive
  • fatigue
  • dizziness
  • nausea
  • pain
  • asthenia
  • renal failure acute

Most common drug interactions by age *:

0-1:
  • muscular weakness
  • tremor
  • atrial fibrillation
  • cerebrovascular accident
  • neoplasm malignant
  • thrombophlebitis superficial
10-19:
  • deep vein thrombosis
  • pain
  • pain in extremity
  • pulmonary embolism
  • chest pain
  • activities of daily living impaired
  • cholelithiasis
  • dizziness
  • hypercoagulation
  • injury
20-29:
  • drug ineffective
  • liver injury
  • deep vein thrombosis
  • pain
  • pulmonary embolism
  • epilepsy
  • hypoglycaemia
  • injury
  • lip injury
  • pain in extremity
30-39:
  • pain
  • anxiety
  • deep vein thrombosis
  • malaise
  • pulmonary embolism
  • type 2 diabetes mellitus
  • urinary tract infection
  • sinus tachycardia
  • convulsion
  • dysphagia
40-49:
  • dyspnoea
  • nausea
  • pain
  • fatigue
  • diabetes mellitus
  • myocardial infarction
  • vomiting
  • headache
  • diarrhoea
  • anxiety
50-59:
  • atrial fibrillation
  • nausea
  • dyspnoea
  • cardiac failure congestive
  • myocardial infarction
  • fatigue
  • oedema peripheral
  • pain
  • diarrhoea
  • international normalised ratio increased
60+:
  • dyspnoea
  • international normalised ratio increased
  • atrial fibrillation
  • nausea
  • cardiac failure congestive
  • fatigue
  • dizziness
  • asthenia
  • fall
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Metformin?

Can you answer these questions?

More questions for: Coumadin, Metformin

You may be interested in these reviews

More reviews for: Coumadin, Metformin

On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.