Review: taking Coumadin and Methadone hydrochloride together


Summary

Drug interactions are reported among people who take Coumadin and Methadone hydrochloride together. This review analyzes the effectiveness and drug interactions between Coumadin and Methadone hydrochloride. It is created by eHealthMe based on reports of 659 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 80,735 users)

Methadone Hydrochloride

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone hydrochloride 2,951 users)

On Aug, 22, 2016

659 people who take Coumadin, Methadone Hydrochloride are studied.


Number of reports submitted per year:

Coumadin and Methadone hydrochloride drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 66.0% - (2 of 3 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 100.0% - (1 of 1 people)
Methadone Hydrochloride:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 66.0% - (4 of 6 people)
  • male: 80.0% - (4 of 5 people)
Methadone Hydrochloride:
  • female: 57.0% - (4 of 7 people)
  • male: 57.0% - (4 of 7 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 66.0% - (2 of 3 people)
  • 60+: 100.0% - (2 of 2 people)
Methadone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 80.0% - (4 of 5 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • radiation mucositis
  • loss of consciousness
  • anaemia
  • bladder cancer
  • cardiac failure
  • death
  • dizziness
  • fall
  • febrile neutropenia
1 - 6 months:
  • radiation mucositis
  • febrile neutropenia
  • neutropenia
  • oropharyngeal pain
  • overdose
  • anaemia
  • coagulopathy
  • crohn's disease
  • depression
  • drug abuse
6 - 12 months:
  • calculus urinary
  • crohn's disease
  • overdose
  • renal impairment
  • suicide attempt
  • anxiety
  • constipation
  • depression
  • drug ineffective
  • musculoskeletal stiffness
1 - 2 years:
  • atrial fibrillation
  • drug abuse
  • drug ineffective
  • feeling abnormal
  • international normalised ratio increased
  • overdose
  • pneumonia
  • retroperitoneal haemorrhage
  • swelling face
2 - 5 years:
  • breast mass
  • calculus ureteric
  • abdominal pain
  • anaemia
  • anhedonia
  • anxiety
  • arthritis
  • asthenia
  • blindness
  • bone disorder
5 - 10 years:
  • pemphigoid
10+ years:
  • erectile dysfunction
not specified:
  • pain
  • dyspnoea
  • anxiety
  • osteonecrosis of jaw
  • back pain
  • cellulitis
  • dizziness
  • nausea
  • pyrexia
  • anaemia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • back pain
  • osteonecrosis of jaw
  • dyspnoea
  • pneumonia
  • urinary tract infection
  • pyrexia
  • weight decreased
  • headache
male:
  • pain
  • dyspnoea
  • anxiety
  • osteonecrosis of jaw
  • cellulitis
  • hypertension
  • anaemia
  • back pain
  • dizziness
  • osteomyelitis

Most common drug interactions by age *:

0-1:
  • international normalised ratio increased
2-9:
  • clostridium difficile colitis
  • irritability
  • withdrawal syndrome
  • application site urticaria
  • rash
10-19:
  • abdominal pain upper
  • abdominal mass
  • abdominal pain
  • actinomycosis
  • albumin globulin ratio decreased
  • alopecia
  • alveolitis
  • amnesia
  • anaemia
  • angina pectoris
20-29:
  • pain
  • pain in extremity
  • cellulitis
  • osteonecrosis of jaw
  • headache
  • asthenia
  • anhedonia
  • anxiety
  • bone disorder
  • injury
30-39:
  • calculus urinary
  • renal impairment
  • pain
  • drug abuse
  • drug ineffective
  • overdose
  • swelling face
  • feeling abnormal
  • nephrogenic systemic fibrosis
  • pain in extremity
40-49:
  • urinary tract infection
  • pyrexia
  • dyspnoea
  • anaemia
  • back pain
  • nausea
  • bone disorder
  • vomiting
  • chest pain
  • osteoarthritis
50-59:
  • pain
  • arthralgia
  • anxiety
  • headache
  • dyspnoea
  • abdominal pain
  • back pain
  • oedema peripheral
  • pneumonia
  • osteonecrosis of jaw
60+:
  • pain
  • anaemia
  • anxiety
  • injury
  • vomiting
  • nausea
  • osteomyelitis
  • osteonecrosis of jaw
  • asthenia
  • cellulitis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Methadone hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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