Review: taking Coumadin and Methotrexate together


Summary

Drug interactions are reported among people who take Coumadin and Methotrexate together. This review analyzes the effectiveness and drug interactions between Coumadin and Methotrexate. It is created by eHealthMe based on reports of 3,185 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,806 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,730 users)

On Sep, 19, 2016

3,185 people who take Coumadin, Methotrexate are studied.


Number of reports submitted per year:

Coumadin and Methotrexate drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 60.0% - (3 of 5 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 75.0% - (3 of 4 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 0.0% - (0 of 3 people)
  • 5 - 10 years: 25.0% - (1 of 4 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 75.0% - (9 of 12 people)
  • male: 85.0% - (6 of 7 people)
Methotrexate:
  • female: 23.0% - (3 of 13 people)
  • male: 42.0% - (3 of 7 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 80.0% - (4 of 5 people)
  • 60+: 72.0% - (8 of 11 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 28.0% - (2 of 7 people)
  • 60+: 36.0% - (4 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • international normalised ratio increased
  • pyrexia
  • atypical pneumonia
  • arthralgia
  • fall
  • platelet count decreased
  • pneumonia
  • stomatitis
  • abdominal pain upper
1 - 6 months:
  • asthenia
  • confusional state
  • anxiety
  • atrial fibrillation
  • gastrointestinal haemorrhage
  • nausea
  • anaemia
  • cellulitis
  • dehydration
  • dizziness
6 - 12 months:
  • rash
  • alopecia
  • liver disorder
  • swelling face
  • atrial fibrillation
  • chest pain
  • decreased appetite
  • exposure to communicable disease
  • gastrooesophageal reflux disease
  • inflammation
1 - 2 years:
  • cerebrovascular accident
  • pulmonary embolism
  • vulval cellulitis
  • diarrhoea
  • diverticulum intestinal haemorrhagic
  • fracture nonunion
  • osteopenia
  • pneumonia
  • vomiting
  • arthralgia
2 - 5 years:
  • cellulitis
  • glioma
  • mycobacterium tuberculosis complex test positive
  • pancytopenia
  • dizziness
  • hearing impaired
  • interstitial lung disease
  • lightheadedness
  • muscle twitching
  • muscle weakness
5 - 10 years:
  • asthenia
  • cerebrovascular accident
  • deep vein thrombosis
  • pleurisy
  • weight decreased
  • arthralgia
  • back pain
  • fall
  • fatigue
  • gait disturbance
10+ years:
  • jaundice cholestatic
  • pancreatic carcinoma
  • asthenia
  • atrial fibrillation
  • dyspnoea
  • dyspnoea at rest
  • oedema peripheral
  • anxiety
  • autoimmune hepatitis
  • bone disorder
not specified:
  • pain
  • atrial fibrillation
  • arthralgia
  • dyspnoea
  • pneumonia
  • fatigue
  • asthenia
  • fall
  • nausea
  • anaemia

Most common drug interactions by gender *:

female:
  • atrial fibrillation
  • pain
  • arthralgia
  • dyspnoea
  • pneumonia
  • fall
  • fatigue
  • nausea
  • anaemia
  • asthenia
male:
  • pneumonia
  • pain
  • atrial fibrillation
  • dyspnoea
  • asthenia
  • arthralgia
  • pyrexia
  • fatigue
  • headache
  • drug ineffective

Most common drug interactions by age *:

2-9:
  • alopecia
  • skin plaque
  • thrombosis
  • therapeutic response unexpected
  • drug ineffective
  • gangrene
  • general physical health deterioration
  • sepsis
  • skin ulcer
  • ulcer
10-19:
  • device dislocation
  • apgar score low
  • cellulitis
  • chondrodystrophy
  • convulsion
  • crohn's disease
  • drug ineffective
  • encephalitis
  • epistaxis
  • foetal exposure during pregnancy
20-29:
  • drug ineffective
  • nasopharyngitis
  • nausea
  • cough
  • pancytopenia
  • vomiting
  • dyspnoea
  • nephrolithiasis
  • pain
  • productive cough
30-39:
  • arthralgia
  • pneumonia
  • nausea
  • pruritus
  • psoriasis
  • back pain
  • chest pain
  • drug ineffective
  • vomiting
  • malaise
40-49:
  • anxiety
  • pneumonia
  • depression
  • pain
  • bronchitis
  • fatigue
  • cataract
  • asthenia
  • headache
  • arthralgia
50-59:
  • fatigue
  • arthralgia
  • dyspnoea
  • pain
  • nausea
  • anaemia
  • cough
  • joint swelling
  • pyrexia
  • atrial fibrillation
60+:
  • atrial fibrillation
  • pain
  • fall
  • pneumonia
  • dyspnoea
  • asthenia
  • arthralgia
  • drug ineffective
  • deep vein thrombosis
  • pyrexia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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