Review: taking Coumadin and Methotrexate together


Summary

Drug interactions are reported among people who take Coumadin and Methotrexate together. This review analyzes the effectiveness and drug interactions between Coumadin and Methotrexate. It is created by eHealthMe based on reports of 2,611 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 80,735 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 152,717 users)

On Aug, 19, 2016

2,611 people who take Coumadin, Methotrexate are studied.


Number of reports submitted per year:

Coumadin and Methotrexate drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 60.0% - (3 of 5 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 75.0% - (3 of 4 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 0.0% - (0 of 3 people)
  • 5 - 10 years: 25.0% - (1 of 4 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 75.0% - (9 of 12 people)
  • male: 85.0% - (6 of 7 people)
Methotrexate:
  • female: 23.0% - (3 of 13 people)
  • male: 42.0% - (3 of 7 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 80.0% - (4 of 5 people)
  • 60+: 72.0% - (8 of 11 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 28.0% - (2 of 7 people)
  • 60+: 36.0% - (4 of 11 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • atypical pneumonia
  • nausea
  • arthralgia
  • fall
  • platelet count decreased
  • stomatitis
  • anaemia
  • arrhythmia
  • cardiac failure congestive
1 - 6 months:
  • anaemia
  • confusional state
  • alopecia
  • asthenia
  • blood pressure increased
  • depression
  • hemiparesis
  • international normalised ratio decreased
  • lethargy
  • loss of consciousness
6 - 12 months:
  • rash
  • alopecia
  • liver disorder
  • atrial fibrillation
  • chest pain
  • decreased appetite
  • exposure to communicable disease
  • gastrooesophageal reflux disease
  • inflammation
  • nausea
1 - 2 years:
  • cerebrovascular accident
  • pulmonary embolism
  • vulval cellulitis
  • diverticulum intestinal haemorrhagic
  • vomiting
  • cerebral haemorrhage
  • constipation
  • deep vein thrombosis
  • diarrhoea
  • hemiplegia
2 - 5 years:
  • cellulitis
  • pancytopenia
  • dizziness
  • hearing impaired
  • lightheadedness
  • muscle twitching
  • muscle weakness
  • shaking palsy
  • vertigo positional
  • balance disorder
5 - 10 years:
  • asthenia
  • cerebrovascular accident
  • weight decreased
  • arthralgia
  • back pain
  • fall
  • fatigue
  • gait disturbance
  • headache
  • hypertension
10+ years:
  • dyspnoea
  • dyspnoea at rest
  • oedema peripheral
  • anxiety
  • asthenia
  • atrial fibrillation
  • autoimmune hepatitis
  • bone disorder
  • cardiac failure chronic
  • femur fracture
not specified:
  • pain
  • atrial fibrillation
  • dyspnoea
  • arthralgia
  • pneumonia
  • anaemia
  • fatigue
  • asthenia
  • fall
  • pulmonary embolism

Most common drug interactions by gender *:

female:
  • pain
  • atrial fibrillation
  • arthralgia
  • dyspnoea
  • anaemia
  • fall
  • pneumonia
  • fatigue
  • pulmonary embolism
  • nausea
male:
  • pneumonia
  • atrial fibrillation
  • dyspnoea
  • asthenia
  • pain
  • pyrexia
  • arthralgia
  • fatigue
  • headache
  • anaemia

Most common drug interactions by age *:

2-9:
  • alopecia
  • skin plaque
  • thrombosis
  • drug ineffective
  • gangrene
  • general physical health deterioration
  • sepsis
  • skin ulcer
  • ulcer
10-19:
  • headache
  • infusion related reaction
  • pneumonia
  • scoliosis
  • vomiting
20-29:
  • pancytopenia
  • drug ineffective
  • international normalised ratio increased
  • wegener's granulomatosis
  • arthralgia
  • diabetes mellitus
  • diarrhoea
  • dizziness
  • dyspnoea
  • hyponatraemia
30-39:
  • arthralgia
  • pneumonia
  • nausea
  • back pain
  • chest pain
  • drug ineffective
  • vomiting
  • abdominal pain
  • acute right ventricular failure
  • anaemia
40-49:
  • pain
  • depression
  • anxiety
  • fatigue
  • pneumonia
  • pulmonary embolism
  • osteonecrosis of jaw
  • arthralgia
  • bronchitis
  • pyrexia
50-59:
  • fatigue
  • arthralgia
  • dyspnoea
  • pain
  • cough
  • anaemia
  • atrial fibrillation
  • joint swelling
  • rheumatoid arthritis
  • headache
60+:
  • atrial fibrillation
  • pain
  • asthenia
  • pneumonia
  • fall
  • dyspnoea
  • anaemia
  • arthralgia
  • pyrexia
  • pulmonary embolism

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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