Coumadin and Methotrexate drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Coumadin and Methotrexate together. This review analyzes the effectiveness and drug interactions between Coumadin and Methotrexate. It is created by eHealthMe based on reports of 3,220 people who take the same drugs from FDA, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from Coumadin 103,651 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 212,550 users)

On Jan, 30, 2017

3,220 people who take Coumadin, Methotrexate are studied.


Number of reports submitted per year:

Coumadin and Methotrexate drug interactions.

Most common drug interactions over time *:

< 1 month:
  • nausea
  • international normalised ratio increased
  • pyrexia
  • atypical pneumonia
  • arthralgia
  • fall
  • platelet count decreased
  • pneumonia
  • stomatitis
  • abdominal pain upper
1 - 6 months:
  • asthenia
  • confusional state
  • gastrointestinal haemorrhage
  • anxiety
  • atrial fibrillation
  • cellulitis
  • nausea
  • anaemia
  • dehydration
  • visual impairment
6 - 12 months:
  • rash
  • alopecia
  • liver disorder
  • nausea
  • swelling face
  • vomiting
  • atrial fibrillation
  • chest pain
  • decreased appetite
  • exposure to communicable disease
1 - 2 years:
  • cerebrovascular accident
  • pulmonary embolism
  • vulval cellulitis
  • diarrhoea
  • diverticulum intestinal haemorrhagic
  • fracture nonunion
  • osteopenia
  • pneumonia
  • vomiting
  • arthralgia
2 - 5 years:
  • glioma
  • mycobacterium tuberculosis complex test positive
  • pancytopenia
  • acute myocardial infarction
  • cellulitis
  • clostridium difficile colitis
  • death
  • interstitial lung disease
  • latent tuberculosis
  • anaemia
5 - 10 years:
  • cerebrovascular accident
  • fall
  • asthenia
  • deep vein thrombosis
  • epistaxis
  • gastrointestinal haemorrhage
  • pleurisy
  • weight decreased
  • arthralgia
  • back pain
10+ years:
  • jaundice cholestatic
  • pancreatic carcinoma
  • asthenia
  • atrial fibrillation
  • dyspnoea
  • oedema peripheral
  • anxiety
  • autoimmune hepatitis
  • bone disorder
  • cardiac failure chronic
not specified:
  • pain
  • atrial fibrillation
  • arthralgia
  • dyspnoea
  • pneumonia
  • fatigue
  • asthenia
  • fall
  • nausea
  • drug ineffective

Most common drug interactions by gender *:

female:
  • pain
  • atrial fibrillation
  • arthralgia
  • dyspnoea
  • fall
  • pneumonia
  • nausea
  • fatigue
  • anaemia
  • asthenia
male:
  • pneumonia
  • pain
  • atrial fibrillation
  • arthralgia
  • dyspnoea
  • asthenia
  • fatigue
  • pyrexia
  • headache
  • drug ineffective

Most common drug interactions by age *:

2-9:
  • alopecia
  • skin plaque
  • thrombosis
  • therapeutic response unexpected
  • drug ineffective
  • gangrene
  • general physical health deterioration
  • sepsis
  • skin ulcer
  • ulcer
10-19:
  • device dislocation
  • apgar score low
  • cellulitis
  • chondrodystrophy
  • convulsion
  • crohn's disease
  • drug ineffective
  • encephalitis
  • epistaxis
  • foetal exposure during pregnancy
20-29:
  • drug ineffective
  • nasopharyngitis
  • nausea
  • cough
  • pancytopenia
  • vomiting
  • dyspnoea
  • nephrolithiasis
  • pain
  • productive cough
30-39:
  • arthralgia
  • pneumonia
  • nausea
  • pruritus
  • psoriasis
  • back pain
  • chest pain
  • drug ineffective
  • vomiting
  • weight increased
40-49:
  • anxiety
  • pneumonia
  • depression
  • pain
  • bronchitis
  • fatigue
  • cataract
  • asthenia
  • headache
  • arthralgia
50-59:
  • fatigue
  • arthralgia
  • dyspnoea
  • pain
  • nausea
  • cough
  • pyrexia
  • anaemia
  • joint swelling
  • headache
60+:
  • atrial fibrillation
  • pain
  • fall
  • pneumonia
  • dyspnoea
  • asthenia
  • arthralgia
  • drug ineffective
  • pyrexia
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Methotrexate?

Interactions between Coumadin and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Methotrexate and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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