Review: taking Coumadin and Norvasc together


Summary

Drug interactions are reported among people who take Coumadin and Norvasc together. This review analyzes the effectiveness and drug interactions between Coumadin and Norvasc. It is created by eHealthMe based on reports of 7,962 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 82,667 users)

Norvasc

Norvasc has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Norvasc 87,169 users)

On Aug, 27, 2016

7,962 people who take Coumadin, Norvasc are studied.


Number of reports submitted per year:

Coumadin and Norvasc drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 25.0% - (2 of 8 people)
  • 1 - 6 months: 50.0% - (8 of 16 people)
  • 6 - 12 months: 71.0% - (5 of 7 people)
  • 1 - 2 years: 61.0% - (8 of 13 people)
  • 2 - 5 years: 77.0% - (14 of 18 people)
  • 5 - 10 years: 58.0% - (7 of 12 people)
  • 10+ years: 94.0% - (18 of 19 people)
  • not specified: 100.0% - (1 of 1 people)
Norvasc:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 21.0% - (3 of 14 people)
  • 6 - 12 months: 37.0% - (3 of 8 people)
  • 1 - 2 years: 22.0% - (4 of 18 people)
  • 2 - 5 years: 59.0% - (13 of 22 people)
  • 5 - 10 years: 58.0% - (10 of 17 people)
  • 10+ years: 73.0% - (11 of 15 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 50.0% - (18 of 36 people)
  • male: 77.0% - (45 of 58 people)
Norvasc:
  • female: 40.0% - (15 of 37 people)
  • male: 47.0% - (29 of 61 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 86.0% - (13 of 15 people)
  • 60+: 63.0% - (46 of 73 people)
Norvasc:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 20.0% - (1 of 5 people)
  • 50-59: 35.0% - (5 of 14 people)
  • 60+: 48.0% - (38 of 78 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • diarrhoea
  • multi-organ failure
  • dyspnoea
  • renal failure
  • neutropenia
  • rash macular
  • septic shock
  • renal failure acute
  • gastrointestinal haemorrhage
1 - 6 months:
  • dyspnoea
  • oedema peripheral
  • headache
  • anxiety
  • cardiac failure congestive
  • cerebrovascular accident
  • haemorrhoids
  • intracranial aneurysm
  • myocardial infarction
  • cellulitis
6 - 12 months:
  • dyspnoea
  • dizziness
  • fall
  • international normalised ratio increased
  • atrial fibrillation
  • renal failure acute
  • bradycardia
  • dyspepsia
  • hypotension
  • pain in extremity
1 - 2 years:
  • hypertension
  • atherosclerosis
  • ischaemic stroke
  • type 2 diabetes mellitus
  • nephrogenic systemic fibrosis
  • nausea
  • asthenia
  • anxiety
  • pyrexia
  • diarrhoea
2 - 5 years:
  • anxiety
  • cerebrovascular accident
  • depression
  • infection
  • loose tooth
  • osteonecrosis
  • blood disorder
  • cardiac disorder
  • impaired healing
  • abdominal pain
5 - 10 years:
  • anxiety
  • mobility decreased
  • nephrogenic systemic fibrosis
  • pain
  • general physical health deterioration
  • international normalised ratio increased
  • rash
  • anaemia
  • discomfort
  • emotional distress
10+ years:
  • international normalised ratio increased
  • gingival bleeding
  • haemoglobin decreased
  • occult blood positive
  • dizziness
  • coagulopathy
  • pain - knee
  • upper gastrointestinal haemorrhage
  • gastric cancer
  • abdominal pain upper
not specified:
  • pain
  • oedema peripheral
  • dyspnoea
  • anxiety
  • nausea
  • atrial fibrillation
  • asthenia
  • fatigue
  • international normalised ratio increased
  • anaemia

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • asthenia
  • oedema peripheral
  • atrial fibrillation
  • dyspnoea
  • anxiety
  • international normalised ratio increased
  • anaemia
  • fatigue
male:
  • pain
  • dyspnoea
  • oedema peripheral
  • anxiety
  • cardiac failure congestive
  • international normalised ratio increased
  • atrial fibrillation
  • asthenia
  • fatigue
  • nausea

Most common drug interactions by age *:

0-1:
  • pleural effusion
  • disseminated intravascular coagulation
  • hepatic function abnormal
  • rhabdomyolysis
  • anaemia
  • pneumonia
  • pulmonary hypertension
  • pyrexia
  • bradycardia
  • death
2-9:
  • fall
  • hip fracture
  • confusional state
  • constipation
  • contusion
  • drug administration error
  • feeling abnormal
  • hallucination, visual
  • hypoacusis
  • road traffic accident
10-19:
  • contusion
  • subdural haematoma
  • syncope
  • deep vein thrombosis
  • skull fracture
  • abdominal distension
  • abdominal pain
  • abscess jaw
  • acidosis hyperchloraemic
  • actinic keratosis
20-29:
  • pain
  • nephrogenic systemic fibrosis
  • mobility decreased
  • oedema
  • skin tightness
  • oedema peripheral
  • skin disorder
  • skin hyperpigmentation
  • peroneal nerve palsy
  • skin depigmentation
30-39:
  • pain
  • nephrogenic systemic fibrosis
  • anxiety
  • skin induration
  • skin tightness
  • renal failure
  • dyspnoea
  • oedema peripheral
  • fibrosis
  • skin hypertrophy
40-49:
  • dyspnoea
  • international normalised ratio increased
  • oedema peripheral
  • pain in extremity
  • erythema
  • fatigue
  • nephrogenic systemic fibrosis
  • arthralgia
  • headache
  • pain
50-59:
  • pain
  • anxiety
  • oedema peripheral
  • nausea
  • depression
  • dyspnoea
  • nephrogenic systemic fibrosis
  • fatigue
  • anaemia
  • pain in extremity
60+:
  • atrial fibrillation
  • international normalised ratio increased
  • pain
  • asthenia
  • dyspnoea
  • nausea
  • oedema peripheral
  • anaemia
  • cardiac failure congestive
  • anxiety

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Norvasc (amlodipine besylate) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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