Review: taking Coumadin and Phenytoin together


Summary

Drug interactions are reported among people who take Coumadin and Phenytoin together. This review analyzes the effectiveness and drug interactions between Coumadin and Phenytoin. It is created by eHealthMe based on reports of 1,843 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,805 users)

Phenytoin

Phenytoin has active ingredients of phenytoin. It is often used in convulsion. (latest outcomes from Phenytoin 12,315 users)

On Sep, 20, 2016

1,843 people who take Coumadin, Phenytoin are studied.


Number of reports submitted per year:

Coumadin and Phenytoin drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 57.0% - (4 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 83.0% - (5 of 6 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Phenytoin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 100.0% - (3 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 100.0% - (1 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 70.0% - (7 of 10 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Coumadin:
  • female: 80.0% - (8 of 10 people)
  • male: 62.0% - (5 of 8 people)
Phenytoin:
  • female: 80.0% - (8 of 10 people)
  • male: 77.0% - (7 of 9 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 42.0% - (3 of 7 people)
  • 50-59: 100.0% - (7 of 7 people)
  • 60+: 66.0% - (2 of 3 people)
Phenytoin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 71.0% - (5 of 7 people)
  • 50-59: 85.0% - (6 of 7 people)
  • 60+: 75.0% - (3 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • alanine aminotransferase increased
  • stevens-johnson syndrome
  • transaminases increased
  • convulsion
  • hereditary angioedema
  • pancreatitis
  • urinary tract infection
  • pancytopenia
  • pyrexia
1 - 6 months:
  • cardiomegaly
  • coma hepatic
  • hepatic failure
  • hepatorenal syndrome
  • hyperthyroidism
  • blindness unilateral
  • hypotension
  • international normalised ratio increased
  • stevens-johnson syndrome
  • delirium
6 - 12 months:
  • myelodysplastic syndrome
  • brain herniation
  • cholecystitis acute
  • cholelithiasis
  • drug level increased
  • fall
  • speech disorder
  • subdural haematoma
  • abdominal wall haematoma
  • blood creatinine increased
1 - 2 years:
  • fall
  • syncope
  • arthropathy
  • atrophy
  • blood viscosity increased
  • dizziness (excl vertigo)
  • insomnia
  • laceration
  • lethargy
  • nervousness
2 - 5 years:
  • fall
  • aphasia
  • cerebral artery embolism
  • cerebral haemorrhage
  • confusional state
  • convulsion
  • haemorrhagic stroke
  • headache
  • insomnia
  • akathisia
5 - 10 years:
  • international normalised ratio increased
  • anticonvulsant drug level decreased
  • convulsion
  • abdominal distension
  • abdominal pain lower
  • aphasia
  • bladder disorder
  • cardiac disorder
  • cardio-respiratory arrest
  • chest pain
10+ years:
  • dizziness
  • arthritis
  • cartilage injury
  • deafness unilateral
  • drug ineffective
  • dysuria
  • fatigue
  • foot fracture
  • herpes zoster
  • hot flushes
not specified:
  • convulsion
  • pain
  • international normalised ratio increased
  • fall
  • dyspnoea
  • asthenia
  • headache
  • fatigue
  • pneumonia
  • anxiety

Most common drug interactions by gender *:

female:
  • pain
  • headache
  • asthenia
  • convulsion
  • depression
  • fall
  • dyspnoea
  • international normalised ratio increased
  • anxiety
  • pain in extremity
male:
  • convulsion
  • international normalised ratio increased
  • fall
  • pain
  • dyspnoea
  • oedema peripheral
  • renal failure
  • deep vein thrombosis
  • fatigue
  • pneumonia

Most common drug interactions by age *:

0-1:
  • sedation
  • weakness
2-9:
  • mucosal haemorrhage
  • thrombocytopenia
  • anxiety
  • death
  • depression
  • fear
  • injury
  • multi-organ failure
  • pain
  • renal failure
10-19:
  • convulsion
  • international normalised ratio increased
  • family stress
  • renal tubular disorder
  • stevens-johnson syndrome
  • tardive dyskinesia
  • alopecia
  • arrhythmia
  • atrial fibrillation
  • bradycardia
20-29:
  • pain
  • nephrogenic systemic fibrosis
  • mobility decreased
  • peroneal nerve palsy
  • skin depigmentation
  • skin tightness
  • oedema
  • dry skin
  • headache
  • skin hyperpigmentation
30-39:
  • pain
  • oedema peripheral
  • nephrogenic systemic fibrosis
  • joint contracture
  • joint range of motion decreased
  • skin hypertrophy
  • skin tightness
  • pruritus
  • anxiety
  • drug ineffective
40-49:
  • deep vein thrombosis
  • urinary tract infection
  • anaemia
  • confusional state
  • oedema peripheral
  • convulsion
  • international normalised ratio increased
  • pancreatitis
  • hereditary angioedema
  • cytokine storm
50-59:
  • arthralgia
  • pain
  • international normalised ratio increased
  • anxiety
  • convulsion
  • pain in extremity
  • fall
  • oedema peripheral
  • back pain
  • bronchitis
60+:
  • convulsion
  • international normalised ratio increased
  • fall
  • pain
  • asthenia
  • depression
  • dyspnoea
  • headache
  • pneumonia
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Phenytoin (phenytoin) is often used to treat convulsion. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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