Review: taking Coumadin and Sertraline together


Summary

Drug interactions are reported among people who take Coumadin and Sertraline together. This review analyzes the effectiveness and drug interactions between Coumadin and Sertraline. It is created by eHealthMe based on reports of 5,201 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,806 users)

Sertraline

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Sertraline 46,905 users)

On Sep, 19, 2016

5,201 people who take Coumadin, Sertraline are studied.


Number of reports submitted per year:

Coumadin and Sertraline drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 62.0% - (5 of 8 people)
  • 6 - 12 months: 90.0% - (9 of 10 people)
  • 1 - 2 years: 75.0% - (9 of 12 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 85.0% - (6 of 7 people)
  • 10+ years: 90.0% - (10 of 11 people)
  • not specified: 0.0% - (0 of 1 people)
Sertraline:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 25.0% - (3 of 12 people)
  • 6 - 12 months: 0.0% - (0 of 9 people)
  • 1 - 2 years: 46.0% - (6 of 13 people)
  • 2 - 5 years: 61.0% - (8 of 13 people)
  • 5 - 10 years: 63.0% - (7 of 11 people)
  • 10+ years: 60.0% - (6 of 10 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 70.0% - (29 of 41 people)
  • male: 66.0% - (18 of 27 people)
Sertraline:
  • female: 38.0% - (16 of 42 people)
  • male: 50.0% - (15 of 30 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 76.0% - (10 of 13 people)
  • 50-59: 68.0% - (15 of 22 people)
  • 60+: 71.0% - (20 of 28 people)
Sertraline:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 40.0% - (2 of 5 people)
  • 40-49: 46.0% - (6 of 13 people)
  • 50-59: 52.0% - (12 of 23 people)
  • 60+: 36.0% - (11 of 30 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • atrial fibrillation
  • dehydration
  • sepsis
  • dyspnoea
  • multi-organ failure
  • cardiovascular disorder
  • gastrointestinal haemorrhage
  • haematuria
  • lower respiratory tract infection
1 - 6 months:
  • international normalised ratio increased
  • hepatic failure
  • confusional state
  • thrombocytopenia
  • bradykinesia
  • bradyphrenia
  • cerebral haemorrhage
  • cough
  • liver disorder
  • oedema peripheral
6 - 12 months:
  • renal failure acute
  • hyperthyroidism
  • hypothyroidism
  • international normalised ratio increased
  • oedema peripheral
  • pain
  • bradykinesia
  • bradyphrenia
  • extrapyramidal disorder
  • pleural effusion
1 - 2 years:
  • anxiety
  • nephrogenic systemic fibrosis
  • gangrene
  • cough
  • pain in extremity
  • pneumonia
  • cellulitis
  • fall
  • impaired healing
  • mental status changes
2 - 5 years:
  • asthenia
  • atrial septal defect
  • cardiac failure congestive
  • congenital anomaly
  • hypocoagulable state
  • cardiomegaly
  • depression
  • foetal exposure during pregnancy
  • ventricular septal defect
  • anaemia
5 - 10 years:
  • depression
  • anxiety
  • aggression
  • intentional overdose
  • loss of consciousness
  • pleural haemorrhage
  • suicide attempt
  • aphasia
  • arthralgia
  • gastrointestinal haemorrhage
10+ years:
  • chest pain
  • pneumonia
  • cardiac failure congestive
  • pulmonary haemorrhage
  • international normalised ratio increased
  • numbness and tingling
  • numbness in hands or feet
  • pulmonary alveolar haemorrhage
  • short-term memory loss
  • spasticity
not specified:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fall
  • fatigue
  • asthenia
  • depression
  • international normalised ratio increased
  • anaemia

Most common drug interactions by gender *:

female:
  • fall
  • nausea
  • pain
  • anxiety
  • dyspnoea
  • fatigue
  • asthenia
  • depression
  • anaemia
  • oedema peripheral
male:
  • pain
  • anxiety
  • dyspnoea
  • nausea
  • fatigue
  • international normalised ratio increased
  • depression
  • asthenia
  • headache
  • cardiac failure congestive

Most common drug interactions by age *:

0-1:
  • muscular weakness
  • tremor
  • bradycardia
  • cerebrovascular accident
  • death
  • dementia alzheimer's type
  • neoplasm malignant
2-9:
  • international normalised ratio increased
  • cardiovascular disorder
  • electrolyte imbalance
  • intentional overdose
  • mental disorder
  • suicide attempt
  • balance disorder
  • irritability
  • cerebral haemorrhage
  • fall
10-19:
  • drug hypersensitivity
  • ill-defined disorder
  • malaise
  • pyrexia
  • blindness
  • death
  • gastrointestinal haemorrhage
  • headache
  • international normalised ratio increased
  • macular degeneration
20-29:
  • vomiting
  • nausea
  • atelectasis
  • anxiety
  • pain
  • pulmonary embolism
  • cough
  • drug ineffective
  • chest pain
  • contusion
30-39:
  • anxiety
  • fatigue
  • weight decreased
  • pain
  • asthenia
  • muscle spasms
  • injury
  • depression
  • malaise
  • urinary tract infection
40-49:
  • anxiety
  • pain
  • pain in extremity
  • dyspnoea
  • depression
  • headache
  • nausea
  • fatigue
  • oedema peripheral
  • deep vein thrombosis
50-59:
  • pain
  • nausea
  • depression
  • anxiety
  • fatigue
  • dyspnoea
  • bone disorder
  • headache
  • anaemia
  • oedema peripheral
60+:
  • fall
  • dyspnoea
  • international normalised ratio increased
  • nausea
  • pain
  • anxiety
  • asthenia
  • cardiac failure congestive
  • atrial fibrillation
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Sertraline (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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