Review: taking Coumadin and Zanaflex together


Summary

Drug interactions are reported among people who take Coumadin and Zanaflex together. This review analyzes the effectiveness and drug interactions between Coumadin and Zanaflex. It is created by eHealthMe based on reports of 438 people who take the same drugs from FDA and social media, and is updated regularly.

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 73,270 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 7,227 users)

On Jul, 23, 2016

438 people who take Coumadin, Zanaflex are studied.


Number of reports submitted per year:

Coumadin and Zanaflex drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 75.0% - (3 of 4 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Zanaflex:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 40.0% - (2 of 5 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 100.0% - (2 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 66.0% - (8 of 12 people)
  • male: 66.0% - (2 of 3 people)
Zanaflex:
  • female: 30.0% - (4 of 13 people)
  • male: 66.0% - (2 of 3 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 83.0% - (5 of 6 people)
  • 60+: 50.0% - (2 of 4 people)
Zanaflex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 50.0% - (3 of 6 people)
  • 60+: 25.0% - (1 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • dehydration
  • dysgeusia
  • fatigue
  • haemodynamic instability
  • headache
  • hypotension
  • international normalised ratio decreased
  • liver function test abnormal
  • respiratory distress
1 - 6 months:
  • anaemia
  • arthralgia
  • coagulopathy
  • convulsion
  • fungal sepsis
  • hyperhidrosis
  • hypokalaemia
  • hypomagnesaemia
  • international normalised ratio decreased
  • nausea
6 - 12 months:
  • anaemia
  • c-reactive protein increased
  • diarrhoea
  • disseminated intravascular coagulation
  • granulocyte count decreased
  • infection
  • pyrexia
  • rash pruritic
  • anxiety and stress
  • stress urinary incontinence
1 - 2 years:
  • aphasia
  • asthenia
  • cellulitis
  • central nervous system lesion
  • clostridium difficile colitis
  • decreased appetite
  • diarrhoea
  • dysarthria
  • dysphagia
  • extremity contracture
2 - 5 years:
  • anaemia
  • stress urinary incontinence
  • convulsion
  • fungal sepsis
  • hypokalaemia
  • hypomagnesaemia
  • neutropenia
  • neutropenic sepsis
  • pericardial effusion
  • clostridium difficile colitis
10+ years:
  • anxiety and stress
not specified:
  • fall
  • pain
  • fatigue
  • asthenia
  • hypotension
  • anxiety
  • nausea
  • pain in extremity
  • diarrhoea
  • pyrexia

Most common drug interactions by gender *:

female:
  • fall
  • pain
  • fatigue
  • asthenia
  • anaemia
  • nausea
  • diarrhoea
  • anxiety
  • hypotension
  • chest pain
male:
  • hypotension
  • oedema peripheral
  • pyrexia
  • asthenia
  • dyspnoea
  • fatigue
  • fall
  • pain
  • anxiety
  • deep vein thrombosis

Most common drug interactions by age *:

0-1:
  • atrioventricular block complete
  • bradycardia
  • death
  • dementia alzheimer's type
  • hypertension
  • pain in extremity
  • syncope
20-29:
  • pulmonary embolism
  • drug ineffective
  • flushing
  • nausea
  • palpitations
  • pressure sore
  • anticonvulsant drug level decreased
  • arthralgia
  • chills
  • constipation
30-39:
  • death
  • hypertension
  • multiple sclerosis
  • asthenia
  • fatigue
  • hypoaesthesia
  • infected cyst
  • pulmonary embolism
  • staphylococcal infection
  • chest pain
40-49:
  • pain in extremity
  • thrombosis
  • deep vein thrombosis
  • fall
  • pyrexia
  • urinary tract infection
  • anxiety
  • asthenia
  • pain
  • vomiting
50-59:
  • asthenia
  • hypotension
  • anaemia
  • fatigue
  • pyrexia
  • headache
  • anxiety
  • dyspnoea
  • nausea
  • depression
60+:
  • fall
  • hypotension
  • pain
  • fatigue
  • diarrhoea
  • nausea
  • asthenia
  • anaemia
  • osteoarthritis
  • coronary artery disease

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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