Coumadin and Zanaflex drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Coumadin and Zanaflex together. This review analyzes the effectiveness and drug interactions between Coumadin and Zanaflex. It is created by eHealthMe based on reports of 766 people who take the same drugs from FDA, and is updated regularly.

What to expect?

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Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from Coumadin 103,655 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 10,449 users)

On Feb, 07, 2017

766 people who take Coumadin, Zanaflex are studied.


Number of reports submitted per year:

Coumadin and Zanaflex drug interactions.

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • dehydration
  • dizziness
  • dysgeusia
  • fatigue
  • gastrointestinal haemorrhage
  • haemodynamic instability
  • headache
  • hypotension
  • international normalised ratio decreased
1 - 6 months:
  • anaemia
  • arthralgia
  • coagulopathy
  • convulsion
  • fungal sepsis
  • hyperhidrosis
  • hypokalaemia
  • hypomagnesaemia
  • international normalised ratio decreased
  • nausea
6 - 12 months:
  • anaemia
  • c-reactive protein increased
  • diarrhoea
  • disseminated intravascular coagulation
  • granulocyte count decreased
  • infection
  • pyrexia
  • rash pruritic
1 - 2 years:
  • aphasia
  • asthenia
  • cellulitis
  • central nervous system lesion
  • clostridium difficile colitis
  • decreased appetite
  • diarrhoea
  • dysarthria
  • dysphagia
  • extremity contracture
2 - 5 years:
  • fungal sepsis
  • hypokalaemia
  • hypomagnesaemia
  • neutropenia
  • neutropenic sepsis
  • pericardial effusion
  • clostridium difficile colitis
  • dizziness
  • anaemia
  • convulsion
5 - 10 years:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
10+ years:
  • epistaxis
  • gastrointestinal haemorrhage
  • back injury
  • hypertension
  • restless legs syndrome
  • sleep apnoea syndrome
not specified:
  • pain
  • gastrooesophageal reflux disease
  • fall
  • nausea
  • fatigue
  • pneumonia
  • dyspnoea
  • anxiety
  • somnolence
  • asthenia

Most common drug interactions by gender *:

female:
  • pain
  • gastrooesophageal reflux disease
  • fall
  • nausea
  • fatigue
  • somnolence
  • pneumonia aspiration
  • asthenia
  • pneumonia
  • coma
male:
  • dyspnoea
  • thrombosis
  • pyrexia
  • fatigue
  • oedema peripheral
  • anxiety
  • depression
  • hypertension
  • hypotension
  • asthenia

Most common drug interactions by age *:

0-1:
  • atrioventricular block complete
  • bradycardia
  • death
  • dementia alzheimer's type
  • hypertension
  • pain in extremity
  • syncope
2-9:
  • clostridium difficile colitis
  • irritability
  • withdrawal syndrome
  • application site urticaria
  • rash
20-29:
  • drug ineffective
  • liver injury
  • memory impairment
  • nausea
  • pulmonary embolism
  • acne
  • contusion
  • cough
  • infection susceptibility increased
  • injection site erythema
30-39:
  • death
  • pneumonia
  • fatigue
  • hypertension
  • multiple sclerosis
  • asthenia
  • dehydration
  • diarrhoea
  • hypoaesthesia
  • infected cyst
40-49:
  • urinary tract infection
  • bronchitis
  • pneumonia
  • depression
  • pneumonia aspiration
  • pulmonary embolism
  • thrombosis
  • cystitis
  • cystitis haemorrhagic
  • hip arthroplasty
50-59:
  • fatigue
  • nausea
  • fall
  • dyspnoea
  • pain
  • asthenia
  • pyrexia
  • anaemia
  • headache
  • anxiety
60+:
  • gastrooesophageal reflux disease
  • somnolence
  • coma
  • pneumonia aspiration
  • hypotension
  • fall
  • pain
  • diarrhoea
  • dyspnoea
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Zanaflex?

Interactions between Coumadin and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Zanaflex and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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