Review: taking Coumadin and Zanaflex together


Summary

Drug interactions are reported among people who take Coumadin and Zanaflex together. This review analyzes the effectiveness and drug interactions between Coumadin and Zanaflex. It is created by eHealthMe based on reports of 756 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Coumadin

Coumadin has active ingredients of warfarin sodium. It is often used in atrial fibrillation/flutter. (latest outcomes from Coumadin 101,806 users)

Zanaflex

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 10,095 users)

On Sep, 19, 2016

756 people who take Coumadin, Zanaflex are studied.


Number of reports submitted per year:

Coumadin and Zanaflex drug interactions.

Drug effectiveness over time:

Coumadin:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 66.0% - (2 of 3 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Zanaflex:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 40.0% - (2 of 5 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Coumadin:
  • female: 66.0% - (8 of 12 people)
  • male: 50.0% - (1 of 2 people)
Zanaflex:
  • female: 30.0% - (4 of 13 people)
  • male: 50.0% - (1 of 2 people)

Drug effectiveness by age:

Coumadin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 80.0% - (4 of 5 people)
  • 60+: 50.0% - (2 of 4 people)
Zanaflex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 50.0% - (1 of 2 people)
  • 40-49: 0.0% - (0 of 2 people)
  • 50-59: 40.0% - (2 of 5 people)
  • 60+: 25.0% - (1 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • international normalised ratio increased
  • dehydration
  • dizziness
  • dysgeusia
  • fatigue
  • gastrointestinal haemorrhage
  • haemodynamic instability
  • headache
  • hypotension
  • international normalised ratio decreased
1 - 6 months:
  • anaemia
  • arthralgia
  • coagulopathy
  • convulsion
  • fungal sepsis
  • hyperhidrosis
  • hypokalaemia
  • hypomagnesaemia
  • international normalised ratio decreased
  • nausea
6 - 12 months:
  • anaemia
  • c-reactive protein increased
  • diarrhoea
  • disseminated intravascular coagulation
  • granulocyte count decreased
  • infection
  • pyrexia
  • rash pruritic
  • anxiety and stress
  • stress urinary incontinence
1 - 2 years:
  • aphasia
  • asthenia
  • cellulitis
  • central nervous system lesion
  • clostridium difficile colitis
  • decreased appetite
  • diarrhoea
  • dysarthria
  • dysphagia
  • extremity contracture
2 - 5 years:
  • neutropenia
  • neutropenic sepsis
  • pericardial effusion
  • clostridium difficile colitis
  • stress urinary incontinence
  • anaemia
  • convulsion
  • fungal sepsis
  • hypokalaemia
  • hypomagnesaemia
5 - 10 years:
  • gastrointestinal haemorrhage
  • rectal haemorrhage
10+ years:
  • epistaxis
  • gastrointestinal haemorrhage
  • anxiety and stress
not specified:
  • pain
  • fall
  • nausea
  • fatigue
  • gastrooesophageal reflux disease
  • dyspnoea
  • pneumonia
  • anxiety
  • asthenia
  • vomiting

Most common drug interactions by gender *:

female:
  • pain
  • fall
  • nausea
  • gastrooesophageal reflux disease
  • fatigue
  • somnolence
  • pneumonia aspiration
  • asthenia
  • pneumonia
  • diarrhoea
male:
  • dyspnoea
  • thrombosis
  • pyrexia
  • fatigue
  • oedema peripheral
  • anxiety
  • depression
  • hypotension
  • asthenia
  • hypertension

Most common drug interactions by age *:

0-1:
  • atrioventricular block complete
  • bradycardia
  • death
  • dementia alzheimer's type
  • hypertension
  • pain in extremity
  • syncope
2-9:
  • clostridium difficile colitis
  • irritability
  • withdrawal syndrome
  • application site urticaria
  • rash
20-29:
  • drug ineffective
  • liver injury
  • memory impairment
  • nausea
  • pulmonary embolism
  • acne
  • contusion
  • cough
  • infection susceptibility increased
  • injection site erythema
30-39:
  • death
  • fatigue
  • hypertension
  • multiple sclerosis
  • pneumonia
  • asthenia
  • dehydration
  • diarrhoea
  • hypoaesthesia
  • infected cyst
40-49:
  • urinary tract infection
  • bronchitis
  • pneumonia
  • depression
  • pneumonia aspiration
  • pulmonary embolism
  • thrombosis
  • cystitis
  • cystitis haemorrhagic
  • hip arthroplasty
50-59:
  • fatigue
  • nausea
  • dyspnoea
  • fall
  • asthenia
  • pyrexia
  • headache
  • pain
  • anxiety
  • hypotension
60+:
  • gastrooesophageal reflux disease
  • somnolence
  • hypotension
  • fall
  • coma
  • pain
  • pneumonia aspiration
  • diarrhoea
  • dyspnoea
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Zanaflex?

Can you answer these questions?

More questions for: Coumadin, Zanaflex

You may be interested in these reviews

More reviews for: Coumadin, Zanaflex

On eHealthMe, Coumadin (warfarin sodium) is often used to treat atrial fibrillation/flutter. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.