Review: taking Cymbalta and Mirapex together


Summary

Drug interactions are reported among people who take Cymbalta and Mirapex together. This review analyzes the effectiveness and drug interactions between Cymbalta and Mirapex. It is created by eHealthMe based on reports of 1,013 people who take the same drugs from FDA and social media, and is updated regularly.

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Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 89,411 users)

Mirapex

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. (latest outcomes from Mirapex 13,040 users)

On Sep, 19, 2016

1,013 people who take Cymbalta, Mirapex are studied.


Number of reports submitted per year:

Cymbalta and Mirapex drug interactions.

Drug effectiveness over time:

Cymbalta:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 6 people)
  • 1 - 2 years: 16.0% - (1 of 6 people)
  • 2 - 5 years: 52.0% - (9 of 17 people)
  • 5 - 10 years: 12.0% - (1 of 8 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Mirapex:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 16.0% - (1 of 6 people)
  • 6 - 12 months: 44.0% - (4 of 9 people)
  • 1 - 2 years: 26.0% - (4 of 15 people)
  • 2 - 5 years: 78.0% - (11 of 14 people)
  • 5 - 10 years: 100.0% - (3 of 3 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Cymbalta:
  • female: 24.0% - (10 of 41 people)
  • male: 16.0% - (2 of 12 people)
Mirapex:
  • female: 45.0% - (18 of 40 people)
  • male: 63.0% - (7 of 11 people)

Drug effectiveness by age:

Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 16.0% - (2 of 12 people)
  • 50-59: 33.0% - (6 of 18 people)
  • 60+: 18.0% - (3 of 16 people)
Mirapex:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 50.0% - (2 of 4 people)
  • 40-49: 18.0% - (2 of 11 people)
  • 50-59: 57.0% - (11 of 19 people)
  • 60+: 62.0% - (10 of 16 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • dizziness
  • haematemesis
  • diplopia
  • fall
  • insomnia
  • somnolence
  • agitation
  • drug withdrawal syndrome
  • dyspnoea
1 - 6 months:
  • confusional state
  • depression
  • pain
  • bradykinesia
  • bradyphrenia
  • emotional distress
  • anhedonia
  • anxiety
  • bereavement reaction
  • dependence
6 - 12 months:
  • fatigue
  • loss of consciousness
  • sudden onset of sleep
  • alanine aminotransferase increased
  • amnesia
  • anger
  • anxiety
  • aspartate aminotransferase increased
  • bladder disorder
  • blood alkaline phosphatase increased
1 - 2 years:
  • insomnia
  • depression
  • headache
  • anxiety
  • gait disturbance
  • pain
  • weight increased
  • anhedonia
  • constipation
  • dizziness
2 - 5 years:
  • bradykinesia
  • bradyphrenia
  • confusional state
  • anxiety
  • pathological gambling
  • obsessive-compulsive disorder
  • depression
  • fatigue
  • nosebleed
  • dizziness
5 - 10 years:
  • obsessive-compulsive disorder
  • pathological gambling
  • depression
  • weight increased
  • abnormal behaviour
  • major depression
  • suicidal ideation
  • headache
  • hyperphagia
  • pain - neck
10+ years:
  • carbohydrate craving
  • depression
  • emotional distress
  • headache
  • heat cramps
  • itching scar
  • joint sprain
  • obsessive-compulsive disorder
  • pathological gambling
  • petechiae
not specified:
  • nausea
  • fall
  • fatigue
  • pain in extremity
  • pain
  • asthenia
  • drug ineffective
  • insomnia
  • diarrhoea
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • fall
  • fatigue
  • pain in extremity
  • pain
  • asthenia
  • insomnia
  • drug ineffective
  • diarrhoea
  • arthralgia
male:
  • fall
  • depression
  • headache
  • drug ineffective
  • dizziness
  • suicidal ideation
  • erythema
  • fatigue
  • insomnia
  • muscle spasms

Most common drug interactions by age *:

10-19:
  • feeling abnormal
  • impulsive behaviour
  • shoplifting
  • fatigue
  • restless legs syndrome
  • somnolence
20-29:
  • agitation
  • cholelithiasis
  • drug exposure during pregnancy
  • nausea
  • emotional distress
  • abdominal pain
  • abdominal pain upper
  • affective disorder
  • anxiety
  • arteriosclerosis
30-39:
  • nausea
  • vomiting
  • abdominal pain
  • muscular weakness
  • urinary tract infection
  • weight decreased
  • back pain
  • diarrhoea
  • headache
  • pain
40-49:
  • insomnia
  • depression
  • dizziness
  • dyspnoea
  • nausea
  • fatigue
  • headache
  • transient ischaemic attack
  • hypokalaemia
  • fall
50-59:
  • insomnia
  • fall
  • nausea
  • pain in extremity
  • diarrhoea
  • asthenia
  • weight increased
  • drug ineffective
  • fatigue
  • pain
60+:
  • fall
  • nausea
  • fatigue
  • pain in extremity
  • drug ineffective
  • asthenia
  • diarrhoea
  • pain
  • dizziness
  • dyspnoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Mirapex (pramipexole dihydrochloride) is often used to treat restless leg syndrome. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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