Review: taking Cymbalta and Zoloft together


Summary

Drug interactions are reported among people who take Cymbalta and Zoloft together. This review analyzes the effectiveness and drug interactions between Cymbalta and Zoloft. It is created by eHealthMe based on reports of 1,629 people who take the same drugs from FDA and social media, and is updated regularly.

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Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 56,552 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 84,365 users)

On Aug, 23, 2016

1,629 people who take Cymbalta, Zoloft are studied.


Number of reports submitted per year:

Cymbalta and Zoloft drug interactions.

Drug effectiveness over time:

Cymbalta:
  • < 1 month: 33.0% - (3 of 9 people)
  • 1 - 6 months: 20.0% - (3 of 15 people)
  • 6 - 12 months: 0.0% - (0 of 7 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 80.0% - (4 of 5 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)
Zoloft:
  • < 1 month: 28.0% - (2 of 7 people)
  • 1 - 6 months: 40.0% - (4 of 10 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 11.0% - (1 of 9 people)
  • 2 - 5 years: 37.0% - (3 of 8 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 4 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Cymbalta:
  • female: 30.0% - (11 of 36 people)
  • male: 12.0% - (1 of 8 people)
Zoloft:
  • female: 27.0% - (10 of 37 people)
  • male: 12.0% - (1 of 8 people)

Drug effectiveness by age:

Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 4 people)
  • 30-39: 38.0% - (5 of 13 people)
  • 40-49: 20.0% - (2 of 10 people)
  • 50-59: 38.0% - (5 of 13 people)
  • 60+: 0.0% - (0 of 2 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 25.0% - (3 of 12 people)
  • 40-49: 20.0% - (2 of 10 people)
  • 50-59: 14.0% - (2 of 14 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • pain
  • pruritus
  • bipolar i disorder
  • diarrhoea
  • hypertension
  • subileus
  • palpitations
  • hyperhidrosis
  • hypersensitivity
1 - 6 months:
  • confusional state
  • anger
  • bradykinesia
  • bradyphrenia
  • type 2 diabetes mellitus
  • depression
  • anxiety
  • hostility
  • pain
  • suicidal ideation
6 - 12 months:
  • anxiety
  • depression
  • hip fracture
  • osteopenia
  • pain
  • rib fracture
  • stress fracture
  • bone density decreased
  • dizziness
  • nausea
1 - 2 years:
  • anger
  • completed suicide
  • erectile dysfunction
  • hostility
  • mood altered
  • depression aggravated
  • feeling abnormal
  • weight increased
  • congenital anomaly
  • coronary artery disease
2 - 5 years:
  • pain
  • pancreatitis
  • anger
  • anxiety
  • depression
  • convulsion
  • road traffic accident
  • sleep apnoea syndrome
  • suicidal ideation
  • hallucination
5 - 10 years:
  • gastrooesophageal reflux disease
  • atrial fibrillation
  • acute myocardial infarction
  • anxiety
  • blood triglycerides increased
  • cerebrovascular accident
  • chest pain
  • coronary artery disease
  • myocardial infarction
  • sinus disorder
10+ years:
  • drug ineffective
  • fatigue
  • somnolence
  • knee arthroplasty
  • suicidal behaviour
  • depression
  • fall
  • grand mal convulsion
  • ventricular septal defect
  • arthropathy
not specified:
  • pain
  • anxiety
  • depression
  • nausea
  • fall
  • drug ineffective
  • headache
  • back pain
  • fatigue
  • arthralgia

Most common drug interactions by gender *:

female:
  • anxiety
  • pain
  • nausea
  • depression
  • fall
  • drug ineffective
  • arthralgia
  • headache
  • weight increased
  • diarrhoea
male:
  • pain
  • headache
  • anxiety
  • depression
  • back pain
  • weight decreased
  • drug ineffective
  • nausea
  • fatigue
  • dizziness

Most common drug interactions by age *:

0-1:
  • drug exposure via breast milk
  • neonatal disorder
  • umbilical cord around neck
  • body temperature fluctuation
  • convulsion neonatal
  • cyanosis neonatal
  • drug exposure during pregnancy
  • dysphagia
  • ischaemic stroke
  • neonatal hypotension
2-9:
  • cardiovascular disorder
  • electrolyte imbalance
  • intentional overdose
  • mental disorder
  • suicide attempt
  • pancreatitis
  • balance disorder
  • diabetic coma
  • foetal exposure during pregnancy
  • international normalised ratio increased
10-19:
  • cholecystitis chronic
  • pain
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • anxiety
  • nausea
  • drug dependence
  • ventricular septal defect
  • disturbance in attention
20-29:
  • nausea
  • drug ineffective
  • abdominal pain
  • abdominal pain upper
  • biliary dyskinesia
  • cholelithiasis
  • depression
  • cholecystitis chronic
  • diarrhoea
  • anxiety
30-39:
  • type 2 diabetes mellitus
  • pain
  • nausea
  • anxiety
  • diabetes mellitus
  • diabetic neuropathy
  • blood cholesterol increased
  • dizziness
  • depression
  • headache
40-49:
  • pain
  • depression
  • drug ineffective
  • type 2 diabetes mellitus
  • anxiety
  • muscle spasms
  • headache
  • back pain
  • arthralgia
  • nausea
50-59:
  • anxiety
  • pain
  • nausea
  • pyrexia
  • depression
  • fall
  • fatigue
  • osteonecrosis of jaw
  • diarrhoea
  • gastrooesophageal reflux disease
60+:
  • pain
  • fall
  • anxiety
  • pain in extremity
  • back pain
  • dizziness
  • anaemia
  • depression
  • pneumonia
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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