Review: taking Cymbalta and Zoloft together


Summary

Drug interactions are reported among people who take Cymbalta and Zoloft together. This review analyzes the effectiveness and drug interactions between Cymbalta and Zoloft. It is created by eHealthMe based on reports of 1,352 people who take the same drugs from FDA and social media, and is updated regularly.

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Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 48,467 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 77,518 users)

On Jul, 27, 2016

1,352 people who take Cymbalta, Zoloft are studied.


Number of reports submitted per year:

Cymbalta and Zoloft drug interactions.

Drug effectiveness over time:

Cymbalta:
  • < 1 month: 23.0% - (3 of 13 people)
  • 1 - 6 months: 13.0% - (3 of 23 people)
  • 6 - 12 months: 0.0% - (0 of 8 people)
  • 1 - 2 years: 37.0% - (3 of 8 people)
  • 2 - 5 years: 87.0% - (7 of 8 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 1 people)
Zoloft:
  • < 1 month: 25.0% - (2 of 8 people)
  • 1 - 6 months: 41.0% - (5 of 12 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 12.0% - (2 of 16 people)
  • 2 - 5 years: 20.0% - (3 of 15 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 4 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Cymbalta:
  • female: 31.0% - (14 of 45 people)
  • male: 11.0% - (2 of 17 people)
Zoloft:
  • female: 23.0% - (11 of 46 people)
  • male: 11.0% - (2 of 17 people)

Drug effectiveness by age:

Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 35.0% - (5 of 14 people)
  • 40-49: 13.0% - (3 of 22 people)
  • 50-59: 47.0% - (8 of 17 people)
  • 60+: 0.0% - (0 of 2 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 40.0% - (2 of 5 people)
  • 30-39: 23.0% - (3 of 13 people)
  • 40-49: 13.0% - (3 of 22 people)
  • 50-59: 16.0% - (3 of 18 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • pain
  • pruritus
  • bipolar i disorder
  • diarrhoea
  • hypertension
  • subileus
  • palpitations
  • hyperhidrosis
  • hypersensitivity
1 - 6 months:
  • confusional state
  • anger
  • bradykinesia
  • bradyphrenia
  • type 2 diabetes mellitus
  • depression
  • hostility
  • anxiety
  • suicidal ideation
  • alanine aminotransferase increased
6 - 12 months:
  • anxiety
  • depression
  • dizziness
  • nausea
  • agitation aggravated
  • bone density decreased
  • confusion
  • fatigue aggravated
  • fear
  • hip fracture
1 - 2 years:
  • anger
  • completed suicide
  • erectile dysfunction
  • hostility
  • mood altered
  • depression aggravated
  • coronary artery disease
  • feeling abnormal
  • movement disorder
  • multiple sclerosis
2 - 5 years:
  • pain
  • pancreatitis
  • anger
  • anxiety
  • depression
  • road traffic accident
  • sleep apnoea syndrome
  • convulsion
  • hallucination
  • suicidal ideation
5 - 10 years:
  • gastrooesophageal reflux disease
  • acute myocardial infarction
  • anxiety
  • atrial fibrillation
  • blood triglycerides increased
  • cerebrovascular accident
  • chest pain
  • coronary artery disease
  • myocardial infarction
  • sinus disorder
10+ years:
  • drug ineffective
  • fatigue
  • somnolence
  • knee arthroplasty
  • suicidal behaviour
  • depression
  • arthropathy
  • blood glucose decreased
  • blood glucose increased
  • blood pressure increased
not specified:
  • pain
  • anxiety
  • depression
  • nausea
  • fall
  • drug ineffective
  • headache
  • type 2 diabetes mellitus
  • back pain
  • fatigue

Most common drug interactions by gender *:

female:
  • anxiety
  • pain
  • nausea
  • depression
  • fall
  • drug ineffective
  • arthralgia
  • diarrhoea
  • type 2 diabetes mellitus
  • bone disorder
male:
  • pain
  • headache
  • anxiety
  • back pain
  • depression
  • type 2 diabetes mellitus
  • weight decreased
  • fatigue
  • road traffic accident
  • vomiting

Most common drug interactions by age *:

0-1:
  • drug exposure via breast milk
  • neonatal disorder
  • umbilical cord around neck
  • body temperature fluctuation
  • convulsion neonatal
  • cyanosis neonatal
  • drug exposure during pregnancy
  • dysphagia
  • ischaemic stroke
  • neonatal hypotension
2-9:
  • foetal exposure during pregnancy
  • low birth weight baby
  • premature baby
10-19:
  • cholecystitis chronic
  • pain
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • anxiety
  • nausea
  • disturbance in attention
  • drug dependence
  • abdominal pain upper
20-29:
  • nausea
  • abdominal pain
  • cholelithiasis
  • abdominal pain upper
  • cholecystitis chronic
  • diarrhoea
  • biliary dyskinesia
  • depression
  • anxiety
  • drug ineffective
30-39:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • anxiety
  • diabetic neuropathy
  • blood cholesterol increased
  • hyperlipidaemia
  • pain
  • arthralgia
  • feeling abnormal
  • neuropathy peripheral
40-49:
  • pain
  • type 2 diabetes mellitus
  • depression
  • anxiety
  • drug ineffective
  • back pain
  • muscle spasms
  • headache
  • arthralgia
  • dyspnoea
50-59:
  • anxiety
  • nausea
  • pain
  • pyrexia
  • fall
  • osteonecrosis of jaw
  • pain in jaw
  • emotional distress
  • fatigue
  • diarrhoea
60+:
  • fall
  • anxiety
  • pain
  • pain in extremity
  • anaemia
  • back pain
  • pneumonia
  • dizziness
  • depression
  • drug ineffective

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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