Cymbalta and Zoloft drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Cymbalta and Zoloft together. This review analyzes the effectiveness and drug interactions between Cymbalta and Zoloft. It is created by eHealthMe based on reports of 2,197 people who take the same drugs from FDA, and is updated regularly.

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Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 92,210 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 99,105 users)

On Feb, 22, 2017

2,197 people who take Cymbalta, Zoloft are studied.


Number of reports submitted per year:

Cymbalta and Zoloft drug interactions.

Most common drug interactions over time *:

< 1 month:
  • nausea
  • pain
  • drug ineffective
  • pruritus
  • bipolar i disorder
  • hypertension
  • diarrhoea
  • subileus
  • anxiety
  • palpitations
1 - 6 months:
  • confusional state
  • anxiety
  • depression
  • bradykinesia
  • bradyphrenia
  • type 2 diabetes mellitus
  • pain
  • suicidal ideation
  • headache
  • hyperhidrosis
6 - 12 months:
  • hip fracture
  • osteopenia
  • pain
  • rib fracture
  • stress fracture
  • bone density decreased
  • anxiety
  • depression
  • drug ineffective
  • type 2 diabetes mellitus
1 - 2 years:
  • feeling abnormal
  • feeling hot
  • hyperhidrosis
  • dizziness
  • migraine
  • nausea
  • suicidal ideation
  • congenital anomaly
  • weight increased
  • insomnia
2 - 5 years:
  • pain
  • pancreatitis
  • anxiety
  • depression
  • convulsion
  • road traffic accident
  • sleep apnoea syndrome
  • suicidal ideation
  • hallucination
  • suicide attempt
5 - 10 years:
  • gastrooesophageal reflux disease
  • anxiety
  • atrial fibrillation
  • acute myocardial infarction
  • atrial septal defect
  • blood triglycerides increased
  • cerebrovascular accident
  • chest pain
  • coronary artery disease
  • myocardial infarction
10+ years:
  • fatigue
  • drug ineffective
  • somnolence
  • fall
  • knee arthroplasty
  • suicidal behaviour
  • anxiety
  • depression
  • grand mal convulsion
  • ventricular septal defect
not specified:
  • pain
  • anxiety
  • depression
  • nausea
  • drug ineffective
  • fall
  • headache
  • fatigue
  • dizziness
  • arthralgia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • depression
  • drug ineffective
  • fall
  • headache
  • dizziness
  • fatigue
  • arthralgia
male:
  • pain
  • anxiety
  • depression
  • drug ineffective
  • nausea
  • dizziness
  • headache
  • fatigue
  • weight decreased
  • back pain

Most common drug interactions by age *:

0-1:
  • drug exposure via breast milk
  • neonatal disorder
  • umbilical cord around neck
  • body temperature fluctuation
  • convulsion neonatal
  • cyanosis neonatal
  • drug exposure during pregnancy
  • dysphagia
  • feeding disorder neonatal
  • foetal exposure during pregnancy
2-9:
  • cardiovascular disorder
  • electrolyte imbalance
  • intentional overdose
  • mental disorder
  • suicide attempt
  • pancreatitis
  • balance disorder
  • diabetic coma
  • foetal exposure during pregnancy
  • international normalised ratio increased
10-19:
  • cholecystitis chronic
  • pain
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • anxiety
  • nausea
  • drug dependence
  • suicidal ideation
  • ventricular septal defect
20-29:
  • nausea
  • drug ineffective
  • abdominal pain
  • depression
  • abdominal pain upper
  • biliary dyskinesia
  • cholelithiasis
  • anxiety
  • cholecystitis chronic
  • diarrhoea
30-39:
  • type 2 diabetes mellitus
  • pain
  • nausea
  • depression
  • anxiety
  • diabetes mellitus
  • dizziness
  • headache
  • diabetic neuropathy
  • feeling abnormal
40-49:
  • pain
  • drug ineffective
  • depression
  • nausea
  • anxiety
  • type 2 diabetes mellitus
  • headache
  • back pain
  • arthralgia
  • muscle spasms
50-59:
  • anxiety
  • pain
  • nausea
  • depression
  • fall
  • fatigue
  • pyrexia
  • headache
  • diarrhoea
  • gastrooesophageal reflux disease
60+:
  • pain
  • anxiety
  • fall
  • dizziness
  • fatigue
  • pain in extremity
  • back pain
  • nausea
  • drug ineffective
  • depression

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Cymbalta and Zoloft?

Interactions between Cymbalta and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Zoloft and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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