Review: taking Depakote er and Keppra together


Summary

Drug interactions are reported among people who take Depakote er and Keppra together. This review analyzes the effectiveness and drug interactions between Depakote er and Keppra. It is created by eHealthMe based on reports of 1,672 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 4,447 users)

Keppra

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 36,047 users)

On Sep, 17, 2016

1,672 people who take Depakote Er, Keppra are studied.


Number of reports submitted per year:

Depakote er and Keppra drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 25.0% - (1 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 50.0% - (3 of 6 people)
  • 2 - 5 years: 14.0% - (1 of 7 people)
  • 5 - 10 years: 87.0% - (7 of 8 people)
  • 10+ years: 66.0% - (6 of 9 people)
  • not specified: 0.0% - (0 of 1 people)
Keppra:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 33.0% - (2 of 6 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 0.0% - (0 of 6 people)
  • 2 - 5 years: 36.0% - (4 of 11 people)
  • 5 - 10 years: 83.0% - (5 of 6 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 29.0% - (5 of 17 people)
  • male: 60.0% - (14 of 23 people)
Keppra:
  • female: 31.0% - (5 of 16 people)
  • male: 43.0% - (10 of 23 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (3 of 3 people)
  • 10-19: 33.0% - (3 of 9 people)
  • 20-29: 70.0% - (7 of 10 people)
  • 30-39: 37.0% - (3 of 8 people)
  • 40-49: 33.0% - (2 of 6 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 0.0% - (0 of 1 people)
Keppra:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 100.0% - (2 of 2 people)
  • 10-19: 10.0% - (1 of 10 people)
  • 20-29: 55.0% - (5 of 9 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 66.0% - (4 of 6 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • granulocytopenia
  • convulsion
  • blood cholesterol increased
  • blood glucose increased
  • blood triglycerides increased
  • haematocrit decreased
  • haemoglobin decreased
  • overdose
  • abnormal behaviour
  • memory impairment
1 - 6 months:
  • convulsion
  • pyrexia
  • drug ineffective
  • fall
  • pain
  • syncope
  • deep vein thrombosis
  • dizziness
  • confusional state
  • grand mal convulsion
6 - 12 months:
  • seizure
  • atrial fibrillation
  • abnormal behaviour
  • asthenia
  • convulsion
  • overdose
  • tremor
  • weight decreased
  • atrophy
  • cognitive disorder
1 - 2 years:
  • somnolence
  • atrophy
  • cognitive disorder
  • gait disturbance
  • memory impairment
  • postictal paralysis
  • speech disorder
  • weight decreased
  • sedation
  • abnormal behaviour
2 - 5 years:
  • convulsion
  • dizziness
  • gait disturbance
  • constipation
  • depression
  • status epilepticus
  • anger
  • asthenia
  • grand mal convulsion
  • headache
5 - 10 years:
  • diabetes mellitus
  • convulsion
  • alopecia
  • diabetic ketoacidosis
  • pancreatitis
  • weight decreased
  • aggression
  • chest pain
  • malaise
  • speech disorder
10+ years:
  • memory impairment
  • convulsion
  • somnolence
  • tremor
  • abnormal loss of weight
  • hypoglycaemia
  • abnormal dreams
  • amnesia
  • anxiety
  • aphonia
not specified:
  • convulsion
  • seizure
  • drug ineffective
  • somnolence
  • tremor
  • fall
  • fatigue
  • dizziness
  • headache
  • anxiety

Most common drug interactions by gender *:

female:
  • convulsion
  • drug ineffective
  • seizure
  • tremor
  • memory impairment
  • decreased appetite
  • dizziness
  • alopecia
  • fatigue
  • anxiety
male:
  • convulsion
  • seizure
  • drug ineffective
  • somnolence
  • fall
  • abnormal behaviour
  • grand mal convulsion
  • aggression
  • dizziness
  • tremor

Most common drug interactions by age *:

0-1:
  • seizure
  • atrial septal defect
  • cyanosis
  • hypoglycaemia
  • hypotonia
  • maternal drugs affecting foetus
  • neonatal respiratory distress syndrome
  • pneumonia
  • prominent epicanthal folds
  • small for dates baby
2-9:
  • convulsion
  • drug ineffective
  • seizure
  • aggression
  • abnormal behaviour
  • epilepsy
  • somnolence
  • lethargy
  • pneumonia
  • adverse drug reaction
10-19:
  • convulsion
  • abnormal behaviour
  • weight decreased
  • somnolence
  • sedation
  • grand mal convulsion
  • seizure
  • dizziness
  • fall
  • vomiting
20-29:
  • convulsion
  • drug ineffective
  • confusional state
  • seizure
  • pregnancy
  • aggression
  • granulocytopenia
  • anxiety
  • somnolence
  • injury
30-39:
  • amnesia
  • anxiety
  • convulsion
  • memory impairment
  • abnormal dreams
  • abnormal loss of weight
  • decreased appetite
  • hypoglycaemia
  • vitamin c deficiency
  • seizure
40-49:
  • convulsion
  • seizure
  • mental status changes
  • somnolence
  • back pain
  • diabetes mellitus
  • weight decreased
  • loss of consciousness
  • aphasia
  • nausea
50-59:
  • convulsion
  • dizziness
  • pyrexia
  • drug ineffective
  • pain
  • seizure
  • syncope
  • deep vein thrombosis
  • fall
  • tremor
60+:
  • convulsion
  • tremor
  • fall
  • confusional state
  • dizziness
  • status epilepticus
  • loss of consciousness
  • pneumonia
  • memory impairment
  • drug ineffective

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex sodium) is often used to treat bipolar disorder. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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