Review: taking Depakote er and Metoprolol tartrate together


Summary

Drug interactions are reported among people who take Depakote er and Metoprolol tartrate together. This review analyzes the effectiveness and drug interactions between Depakote er and Metoprolol tartrate. It is created by eHealthMe based on reports of 765 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 4,447 users)

Metoprolol Tartrate

Metoprolol tartrate has active ingredients of metoprolol tartrate. It is often used in high blood pressure. (latest outcomes from Metoprolol tartrate 46,723 users)

On Sep, 17, 2016

765 people who take Depakote Er, Metoprolol Tartrate are studied.


Number of reports submitted per year:

Depakote er and Metoprolol tartrate drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 100.0% - (1 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Metoprolol Tartrate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 16.0% - (1 of 6 people)
  • 6 - 12 months: 20.0% - (1 of 5 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 66.0% - (2 of 3 people)
  • male: 40.0% - (4 of 10 people)
Metoprolol Tartrate:
  • female: 0.0% - (0 of 3 people)
  • male: 27.0% - (3 of 11 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 50.0% - (1 of 2 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 50.0% - (2 of 4 people)
Metoprolol Tartrate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 50.0% - (1 of 2 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 20.0% - (1 of 5 people)

Most common drug interactions over time *:

< 1 month:
  • agitation
  • memory impairment
  • mental disorder
  • somnolence
  • convulsion
  • fatigue
  • overdose
  • trismus
  • abdominal pain
  • anxiety
1 - 6 months:
  • anaphylactic shock
  • atrial fibrillation
  • gastrointestinal haemorrhage
  • haemoptysis
  • rectal haemorrhage
  • arthritis
  • gastrointestinal disorder
  • liver injury
  • blood creatine phosphokinase increased
  • arthralgia
6 - 12 months:
  • hypomagnesemia
  • pancreatitis haemorrhagic
  • pancreatitis necrotising
1 - 2 years:
  • conjunctival haemorrhage
  • gastrointestinal haemorrhage
  • thrombocytopenia
  • nephrogenic systemic fibrosis
  • seizure
2 - 5 years:
  • hypertension
  • liver function test abnormal
  • type 2 diabetes mellitus
  • diabetic complication
  • diabetic ketoacidosis
  • dyslipidaemia
  • gastric ulcer
  • hyperglycaemia
  • loss of bladder control
  • loss of control of legs
5 - 10 years:
  • type 2 diabetes mellitus
  • arteriosclerosis coronary artery
  • back pain
  • cardiomegaly
  • cardiomyopathy
  • confusion
  • convulsion
  • coronary artery disease
  • diabetes mellitus
  • diabetic ketoacidosis
10+ years:
  • dysphagia
  • colon cancer
  • depressed level of consciousness
  • diarrhoea
  • epigastric discomfort
  • fall
  • neuralgia
  • oesophageal polyp
  • post procedural complication
  • sinusitis
not specified:
  • hypertension
  • pain
  • dyspnoea
  • diabetes mellitus
  • nausea
  • anxiety
  • type 2 diabetes mellitus
  • convulsion
  • fall
  • back pain

Most common drug interactions by gender *:

female:
  • pain
  • hypertension
  • nausea
  • dyspnoea
  • anxiety
  • fall
  • back pain
  • type 2 diabetes mellitus
  • dizziness
  • headache
male:
  • diabetes mellitus
  • hypertension
  • dyspnoea
  • somnolence
  • type 2 diabetes mellitus
  • convulsion
  • fatigue
  • pain
  • arthralgia
  • pneumonia

Most common drug interactions by age *:

10-19:
  • type 2 diabetes mellitus
  • cataract
  • cerebral haemorrhage
  • dysuria
  • fall
  • head injury
  • prostatic disorder
  • urinary tract infection
  • urosepsis
  • visual acuity reduced
20-29:
  • hypertension
  • weight increased
  • diabetes mellitus non-insulin-dependent
  • hyperglycaemia
  • prescribed overdose
  • pulmonary embolism
  • blood cholesterol increased
  • deep vein thrombosis
  • diabetic ketoacidosis
  • nausea
30-39:
  • diabetes mellitus
  • arthralgia
  • pain
  • hypertension
  • weight increased
  • anxiety
  • type 2 diabetes mellitus
  • malaise
  • agitation
  • pain in extremity
40-49:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • chest pain
  • diabetic neuropathy
  • diabetes mellitus inadequate control
  • hypertension
  • back pain
  • nausea
  • arthralgia
  • vomiting
50-59:
  • dyspnoea
  • pain
  • hypertension
  • convulsion
  • malaise
  • anxiety
  • headache
  • gastrooesophageal reflux disease
  • tachycardia
  • diabetes mellitus
60+:
  • atrial fibrillation
  • confusional state
  • nausea
  • tremor
  • fall
  • urinary tract infection
  • convulsion
  • dehydration
  • asthenia
  • pneumonia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex sodium) is often used to treat bipolar disorder. Metoprolol tartrate (metoprolol tartrate) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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