Review: taking Depakote er and Prevacid together


Summary

Drug interactions are reported among people who take Depakote er and Prevacid together. This review analyzes the effectiveness and drug interactions between Depakote er and Prevacid. It is created by eHealthMe based on reports of 805 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 3,580 users)

Prevacid

Prevacid has active ingredients of lansoprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Prevacid 40,313 users)

On Jul, 27, 2016

805 people who take Depakote Er, Prevacid are studied.


Number of reports submitted per year:

Depakote er and Prevacid drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 83.0% - (5 of 6 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Prevacid:
  • < 1 month: 100.0% - (1 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 100.0% - (2 of 2 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 72.0% - (8 of 11 people)
  • male: 40.0% - (2 of 5 people)
Prevacid:
  • female: 60.0% - (6 of 10 people)
  • male: 40.0% - (2 of 5 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 83.0% - (5 of 6 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 33.0% - (1 of 3 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (4 of 4 people)
Prevacid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (4 of 6 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 33.0% - (1 of 3 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 66.0% - (2 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • confusional state
  • hyponatraemia
  • large intestine perforation
  • multi-organ failure
  • pneumomediastinum
  • subcutaneous emphysema
  • blood pressure increased
  • chest pain
  • frequent headaches
  • heart pounding
1 - 6 months:
  • pyrexia
  • vomiting
  • dehydration
  • pancreatitis
  • abdominal pain
  • colitis
  • diarrhoea
  • disseminated intravascular coagulation
  • pseudocyst
  • thrombocytopenia
6 - 12 months:
  • aggression
  • agitation
  • ammonia increased
  • blood cholesterol increased
  • blood triglycerides increased
  • catatonia
  • contusion
  • epistaxis
  • fatigue
  • hepatic enzyme increased
1 - 2 years:
  • blood pressure increased
  • chest pain
  • frequent headaches
  • heart pounding
  • heart rate increased
  • stomach pain
  • diabetic neuropathy
  • hallucination
  • type 2 diabetes mellitus
  • vaginal odour
2 - 5 years:
  • insomnia
  • back pain
  • breast cancer in situ
  • gastrooesophageal reflux disease
  • mitral valve incompetence
  • multiple sclerosis relapse
  • muscle spasms
  • ammonia increased
  • delirium
  • drug level decreased
5 - 10 years:
  • abdominal discomfort
  • nausea
10+ years:
  • obesity
  • breast mass
  • perirectal abscess
  • thrombosis
  • type 2 diabetes mellitus
  • weight increased
  • anticoagulation drug level above therapeutic
  • diabetes mellitus inadequate control
  • diabetic ketoacidosis
  • thrombophlebitis superficial
not specified:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • depression
  • anxiety
  • nausea
  • fall
  • fatigue
  • headache
  • drug ineffective
  • insomnia

Most common drug interactions by gender *:

female:
  • type 2 diabetes mellitus
  • nausea
  • vomiting
  • headache
  • diabetes mellitus
  • insomnia
  • abdominal pain
  • back pain
  • dyspnoea
  • depression
male:
  • anxiety
  • depression
  • diabetes mellitus
  • fatigue
  • drug ineffective
  • fall
  • weight decreased
  • pain in extremity
  • type 2 diabetes mellitus
  • agitation

Most common drug interactions by age *:

0-1:
  • arthritis
  • blood cholesterol increased
  • cerebrovascular accident
  • convulsion
  • diabetic neuropathy
  • dyspnoea
  • haematochezia
  • hypercalcaemia
  • hyperlipidaemia
  • hypertension
2-9:
  • hypoventilation
  • lethargy
  • palpitations
  • convulsion
  • drug ineffective
  • death
  • urine ketone body present
10-19:
  • pancreatitis
  • vomiting
  • abdominal pain
  • dehydration
  • diarrhoea
  • contusion
  • tardive dyskinesia
  • colitis
  • pyrexia
  • confusional state
20-29:
  • drug ineffective
  • suicide attempt
  • anxiety
  • type 2 diabetes mellitus
  • agitation
  • blood cholesterol increased
  • depression
  • diabetes mellitus
  • insomnia
  • pancreatitis
30-39:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • back pain
  • pain in extremity
  • pancreatitis
  • diabetes mellitus inadequate control
  • weight increased
  • diabetic neuropathy
  • ill-defined disorder
  • insomnia
40-49:
  • gastrooesophageal reflux disease
  • type 2 diabetes mellitus
  • diabetes mellitus
  • dyspnoea
  • hyperhidrosis
  • anxiety
  • road traffic accident
  • diabetes mellitus inadequate control
  • insomnia
  • back pain
50-59:
  • dizziness
  • anxiety
  • headache
  • nausea
  • somnolence
  • mania
  • type 2 diabetes mellitus
  • diabetes mellitus inadequate control
  • depression
  • drug ineffective
60+:
  • fall
  • fatigue
  • anaemia
  • blood glucose increased
  • oedema peripheral
  • deep vein thrombosis
  • injury
  • contusion
  • decreased appetite
  • cardiomegaly

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex sodium) is often used to treat bipolar disorder. Prevacid (lansoprazole) is often used to treat gastrooesophageal reflux disease. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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