Review: taking Depakote er and Wellbutrin xl together


Summary

Drug interactions are reported among people who take Depakote er and Wellbutrin xl together. This review analyzes the effectiveness and drug interactions between Depakote er and Wellbutrin xl. It is created by eHealthMe based on reports of 2,037 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex. It is often used in bipolar disorder. (latest outcomes from Depakote er 3,587 users)

Wellbutrin Xl

Wellbutrin xl has active ingredients of bupropion. It is often used in depression. (latest outcomes from Wellbutrin xl 13,265 users)

On Jul, 20, 2016

2,037 people who take Depakote Er, Wellbutrin Xl are studied.


Number of reports submitted per year:

Depakote er and Wellbutrin xl drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 21.0% - (3 of 14 people)
  • 1 - 6 months: 20.0% - (3 of 15 people)
  • 6 - 12 months: 46.0% - (6 of 13 people)
  • 1 - 2 years: 52.0% - (10 of 19 people)
  • 2 - 5 years: 57.0% - (12 of 21 people)
  • 5 - 10 years: 50.0% - (11 of 22 people)
  • 10+ years: 47.0% - (11 of 23 people)
  • not specified: 33.0% - (1 of 3 people)
Wellbutrin Xl:
  • < 1 month: 33.0% - (4 of 12 people)
  • 1 - 6 months: 6.0% - (1 of 16 people)
  • 6 - 12 months: 23.0% - (3 of 13 people)
  • 1 - 2 years: 37.0% - (9 of 24 people)
  • 2 - 5 years: 44.0% - (13 of 29 people)
  • 5 - 10 years: 57.0% - (15 of 26 people)
  • 10+ years: 25.0% - (4 of 16 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 36.0% - (24 of 65 people)
  • male: 50.0% - (33 of 65 people)
Wellbutrin Xl:
  • female: 27.0% - (19 of 68 people)
  • male: 42.0% - (30 of 70 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 66.0% - (2 of 3 people)
  • 20-29: 44.0% - (8 of 18 people)
  • 30-39: 22.0% - (7 of 31 people)
  • 40-49: 57.0% - (12 of 21 people)
  • 50-59: 58.0% - (20 of 34 people)
  • 60+: 34.0% - (8 of 23 people)
Wellbutrin Xl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (1 of 4 people)
  • 20-29: 36.0% - (7 of 19 people)
  • 30-39: 29.0% - (10 of 34 people)
  • 40-49: 27.0% - (6 of 22 people)
  • 50-59: 58.0% - (20 of 34 people)
  • 60+: 20.0% - (5 of 25 people)

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • nausea
  • paranoia
  • vertigo
  • abdominal pain
  • amnesia
  • suicidal ideation
  • swelling face
  • arnold-chiari malformation
  • chills
1 - 6 months:
  • depression
  • dysarthria
  • feeling abnormal
  • overdose
  • tremor
  • amnesia
  • facial palsy
  • hypersensitivity
  • suicide attempt
  • vomiting
6 - 12 months:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • suicidal ideation
  • anxiety
  • blood triglycerides increased
  • depression
  • blood cholesterol increased
  • obesity
  • suicidal behaviour
  • tremor
1 - 2 years:
  • tremor
  • alopecia
  • erectile dysfunction
  • weight increased
  • dyspnoea
  • type 2 diabetes mellitus
  • abdominal bloating
  • amnesia
  • blood glucose increased
  • blood pressure increased
2 - 5 years:
  • depression
  • fatigue
  • weight increased
  • vomiting
  • diabetes mellitus
  • anorexia
  • confusion
  • tremors
  • weakness
  • hypertension
5 - 10 years:
  • vision blurred
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • hypertension
  • dark circles under eyes
  • dizziness
  • erectile dysfunction
  • fatigue
  • insomnia related to another mental condition
10+ years:
  • anxiety
  • obesity
  • agoraphobia
  • social phobia
  • impotence
  • lack of strength, muscle weakness, weakness
  • muscle cramps
  • memory impairment
  • weight increased
  • balance disorder
not specified:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • depression
  • suicidal ideation
  • insomnia
  • suicide attempt
  • blood cholesterol increased
  • obesity
  • chest pain

Most common drug interactions by gender *:

female:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • depression
  • suicidal ideation
  • nausea
  • blood cholesterol increased
  • obesity
  • insomnia
  • dizziness
male:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • suicidal ideation
  • depression
  • suicide attempt
  • tremor
  • insomnia
  • chest pain
  • obesity

Most common drug interactions by age *:

0-1:
  • headache
  • pancreatitis
  • abasia
  • abdominal pain
  • abscess
  • amnesia
  • anaemia
  • balance disorder
  • brain damage
  • clostridium difficile colitis
2-9:
  • bipolar i disorder
  • drug ineffective
  • grand mal convulsion
  • personality change
  • respiratory arrest (excl neonatal)
  • status epilepticus
  • abnormal behaviour
  • decreased appetite
  • disturbance in attention
  • dystonia
10-19:
  • suicidal ideation
  • suicide attempt
  • weight increased
  • self mutilation
  • agitation
  • headache
  • overdose
  • fatigue
  • feeling abnormal
  • hallucination, auditory
20-29:
  • diabetes mellitus
  • nausea
  • type 2 diabetes mellitus
  • suicidal ideation
  • weight increased
  • blood cholesterol increased
  • depression
  • insomnia
  • mania
  • suicide attempt
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • obesity
  • diabetes mellitus inadequate control
  • blood cholesterol increased
  • suicidal ideation
  • blood triglycerides increased
  • depression
  • diabetic neuropathy
40-49:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • blood cholesterol increased
  • chest pain
  • obesity
  • blood triglycerides increased
  • back pain
  • depression
  • suicidal ideation
50-59:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • insomnia
  • neuropathy peripheral
  • depression
  • chest pain
  • dizziness
  • suicide attempt
  • obesity
  • diabetic neuropathy
60+:
  • tremor
  • depression
  • anxiety
  • diabetes mellitus
  • drug ineffective
  • suicidal ideation
  • fatigue
  • weight increased
  • fall
  • balance disorder

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex) is often used to treat bipolar disorder. Wellbutrin xl (bupropion) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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