Review: taking Depakote er and Wellbutrin xl together


Summary

Drug interactions are reported among people who take Depakote er and Wellbutrin xl together. This review analyzes the effectiveness and drug interactions between Depakote er and Wellbutrin xl. It is created by eHealthMe based on reports of 2,411 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 4,447 users)

Wellbutrin Xl

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin xl 15,450 users)

On Sep, 19, 2016

2,411 people who take Depakote Er, Wellbutrin Xl are studied.


Number of reports submitted per year:

Depakote er and Wellbutrin xl drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 20.0% - (3 of 15 people)
  • 6 - 12 months: 50.0% - (7 of 14 people)
  • 1 - 2 years: 42.0% - (6 of 14 people)
  • 2 - 5 years: 43.0% - (7 of 16 people)
  • 5 - 10 years: 52.0% - (10 of 19 people)
  • 10+ years: 53.0% - (8 of 15 people)
  • not specified: 50.0% - (1 of 2 people)
Wellbutrin Xl:
  • < 1 month: 36.0% - (4 of 11 people)
  • 1 - 6 months: 6.0% - (1 of 15 people)
  • 6 - 12 months: 25.0% - (3 of 12 people)
  • 1 - 2 years: 33.0% - (7 of 21 people)
  • 2 - 5 years: 45.0% - (10 of 22 people)
  • 5 - 10 years: 52.0% - (11 of 21 people)
  • 10+ years: 27.0% - (3 of 11 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 38.0% - (21 of 54 people)
  • male: 45.0% - (24 of 53 people)
Wellbutrin Xl:
  • female: 31.0% - (18 of 57 people)
  • male: 36.0% - (21 of 57 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 66.0% - (2 of 3 people)
  • 20-29: 47.0% - (8 of 17 people)
  • 30-39: 27.0% - (8 of 29 people)
  • 40-49: 55.0% - (11 of 20 people)
  • 50-59: 52.0% - (13 of 25 people)
  • 60+: 23.0% - (3 of 13 people)
Wellbutrin Xl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (1 of 4 people)
  • 20-29: 38.0% - (7 of 18 people)
  • 30-39: 28.0% - (9 of 32 people)
  • 40-49: 25.0% - (5 of 20 people)
  • 50-59: 52.0% - (13 of 25 people)
  • 60+: 26.0% - (4 of 15 people)

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • nausea
  • paranoia
  • vertigo
  • abdominal pain
  • amnesia
  • fall
  • overdose
  • suicidal ideation
  • swelling face
1 - 6 months:
  • depression
  • tremor
  • dysarthria
  • feeling abnormal
  • overdose
  • amnesia
  • facial palsy
  • hypersensitivity
  • suicidal ideation
  • suicide attempt
6 - 12 months:
  • type 2 diabetes mellitus
  • anxiety
  • diabetes mellitus
  • suicidal ideation
  • blood triglycerides increased
  • depression
  • panic attack
  • blood cholesterol increased
  • obesity
  • overdose
1 - 2 years:
  • tremor
  • alopecia
  • dyspnoea
  • erectile dysfunction
  • weight increased
  • anxiety
  • type 2 diabetes mellitus
  • abdominal bloating
  • amnesia
  • blood cholesterol increased
2 - 5 years:
  • depression
  • fatigue
  • weight increased
  • vomiting
  • diabetes mellitus
  • anorexia
  • confusion
  • tremors
  • weakness
  • hypertension
5 - 10 years:
  • vision blurred
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • hypertension
  • dark circles under eyes
  • dizziness
  • erectile dysfunction
  • fatigue
  • insomnia related to another mental condition
10+ years:
  • anxiety
  • obesity
  • agoraphobia
  • social phobia
  • impotence
  • lack of strength, muscle weakness, weakness
  • muscle cramps
  • weight increased
  • balance disorder
  • diabetes mellitus
not specified:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • depression
  • suicidal ideation
  • drug ineffective
  • insomnia
  • anxiety
  • headache
  • fatigue

Most common drug interactions by gender *:

female:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • depression
  • suicidal ideation
  • fatigue
  • anxiety
  • nausea
  • insomnia
  • headache
male:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • suicidal ideation
  • depression
  • drug ineffective
  • suicide attempt
  • insomnia
  • tremor
  • headache

Most common drug interactions by age *:

0-1:
  • headache
  • pancreatitis
  • pericardial effusion
  • abasia
  • abdominal pain
  • abscess
  • amnesia
  • anaemia
  • aorta hypoplasia
  • atrial septal defect
2-9:
  • bipolar i disorder
  • drug ineffective
  • grand mal convulsion
  • personality change
  • respiratory arrest (excl neonatal)
  • status epilepticus
  • abnormal behaviour
  • decreased appetite
  • disturbance in attention
  • dystonia
10-19:
  • suicidal ideation
  • suicide attempt
  • weight increased
  • self mutilation
  • agitation
  • fatigue
  • headache
  • overdose
  • feeling abnormal
  • hallucination, auditory
20-29:
  • diabetes mellitus
  • nausea
  • type 2 diabetes mellitus
  • suicidal ideation
  • weight increased
  • depression
  • blood cholesterol increased
  • insomnia
  • suicide attempt
  • mania
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • obesity
  • suicidal ideation
  • diabetes mellitus inadequate control
  • blood cholesterol increased
  • depression
  • blood triglycerides increased
  • anxiety
40-49:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • blood cholesterol increased
  • chest pain
  • hypertension
  • suicidal ideation
  • obesity
  • blood triglycerides increased
  • depression
50-59:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • insomnia
  • depression
  • dizziness
  • chest pain
  • neuropathy peripheral
  • suicide attempt
  • suicidal ideation
  • weight increased
60+:
  • anxiety
  • depression
  • tremor
  • drug ineffective
  • weight increased
  • diabetes mellitus
  • suicidal ideation
  • malaise
  • fatigue
  • gait disturbance

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex sodium) is often used to treat bipolar disorder. Wellbutrin xl (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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