Review: taking Depakote er and Xanax together


Summary

Drug interactions are reported among people who take Depakote er and Xanax together. This review analyzes the effectiveness and drug interactions between Depakote er and Xanax. It is created by eHealthMe based on reports of 2,101 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote Er

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 4,447 users)

Xanax

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. (latest outcomes from Xanax 82,506 users)

On Sep, 15, 2016

2,101 people who take Depakote Er, Xanax are studied.


Number of reports submitted per year:

Depakote er and Xanax drug interactions.

Drug effectiveness over time:

Depakote Er:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 22.0% - (2 of 9 people)
  • 6 - 12 months: 14.0% - (1 of 7 people)
  • 1 - 2 years: 0.0% - (0 of 10 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 0 people)
Xanax:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 57.0% - (4 of 7 people)
  • 6 - 12 months: 40.0% - (4 of 10 people)
  • 1 - 2 years: 50.0% - (3 of 6 people)
  • 2 - 5 years: 28.0% - (4 of 14 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 71.0% - (5 of 7 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Depakote Er:
  • female: 16.0% - (5 of 30 people)
  • male: 26.0% - (4 of 15 people)
Xanax:
  • female: 42.0% - (15 of 35 people)
  • male: 43.0% - (7 of 16 people)

Drug effectiveness by age:

Depakote Er:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 20.0% - (1 of 5 people)
  • 30-39: 22.0% - (2 of 9 people)
  • 40-49: 18.0% - (3 of 16 people)
  • 50-59: 22.0% - (2 of 9 people)
  • 60+: 20.0% - (1 of 5 people)
Xanax:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (3 of 6 people)
  • 30-39: 33.0% - (4 of 12 people)
  • 40-49: 50.0% - (9 of 18 people)
  • 50-59: 44.0% - (4 of 9 people)
  • 60+: 33.0% - (2 of 6 people)

Most common drug interactions over time *:

< 1 month:
  • coma
  • intentional overdose
  • neutropenia
  • overdose
  • confusional state
  • loss of consciousness
  • somnolence
  • suicide attempt
  • thrombocytopenia
  • vomiting
1 - 6 months:
  • drug exposure during pregnancy
  • ventricular septal defect
  • anaemia
  • atrial septal defect
  • respiratory distress
  • apnoea
  • foetal distress syndrome
  • anxiety
  • hypotension
  • aortic disorder
6 - 12 months:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • back pain
  • blood cholesterol increased
  • blood triglycerides increased
  • involuntary body movements
  • mouth dry aggravated
  • stuttering
  • tremor - drug-induced
  • bone loss
1 - 2 years:
  • drug exposure during pregnancy
  • type 2 diabetes mellitus
  • ventricular septal defect
  • atrial septal defect
  • anaemia
  • apnoea
  • foetal distress syndrome
  • respiratory distress
  • blood cholesterol increased
  • diabetes mellitus
2 - 5 years:
  • nausea
  • pain
  • vomiting
  • sleep apnoea syndrome
  • diabetic neuropathy
  • hyperglycaemia
  • type 2 diabetes mellitus
  • acute respiratory failure
  • cardiomyopathy
  • diabetic coma
5 - 10 years:
  • dizziness
  • fall
  • headache
  • blood count abnormal
  • blood triglycerides increased
  • burning sensation
  • convulsion
  • cystitis
  • drug ineffective
  • hypertension
10+ years:
  • type 2 diabetes mellitus
  • diabetes mellitus inadequate control
  • weight increased
  • drug ineffective
  • diabetes mellitus
  • breast mass
  • obesity
  • perirectal abscess
  • thrombosis
  • anticoagulation drug level above therapeutic
not specified:
  • depression
  • weight increased
  • anxiety
  • dyspnoea
  • fall
  • headache
  • tremor
  • suicidal ideation
  • diabetes mellitus
  • pain

Most common drug interactions by gender *:

female:
  • depression
  • weight increased
  • dyspnoea
  • headache
  • fall
  • anxiety
  • pain
  • back pain
  • dizziness
  • tremor
male:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • anxiety
  • weight increased
  • nausea
  • depression
  • suicidal ideation
  • insomnia
  • vomiting
  • drug ineffective

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • agitation neonatal
  • congenital anomaly
  • congenital mitral valve incompetence
  • drug exposure during pregnancy
  • drug withdrawal syndrome neonatal
  • neonatal respiratory distress syndrome
  • oligohydramnios
  • premature baby
  • shoulder dystocia
2-9:
  • brain damage
  • coma
  • hepatic failure
  • overdose
10-19:
  • weight increased
  • anxiety
  • cardiac disorder
  • fall
  • hallucination
  • lung disorder
  • malaise
  • nausea
  • pancreatitis acute
  • somnolence
20-29:
  • overdose
  • convulsion
  • type 2 diabetes mellitus
  • abdominal pain
  • diabetes mellitus
  • weight increased
  • suicide attempt
  • injury
  • pain
  • dyspnoea
30-39:
  • type 2 diabetes mellitus
  • weight increased
  • diabetes mellitus
  • nausea
  • anxiety
  • depression
  • arthralgia
  • headache
  • dizziness
  • insomnia
40-49:
  • type 2 diabetes mellitus
  • depression
  • anxiety
  • diabetes mellitus
  • pain
  • suicidal ideation
  • headache
  • neuropathy peripheral
  • insomnia
  • vomiting
50-59:
  • depression
  • fall
  • weight increased
  • back pain
  • dyspnoea
  • insomnia
  • suicide attempt
  • suicidal ideation
  • drug ineffective
  • tremor
60+:
  • fall
  • dizziness
  • loss of consciousness
  • anaemia
  • vomiting
  • confusional state
  • headache
  • nausea
  • thrombocytopenia
  • weight decreased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote er (divalproex sodium) is often used to treat bipolar disorder. Xanax (alprazolam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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