Review: taking Depakote and Advil pm together


Drug interactions are reported only by a few people who take Depakote and Advil pm together. This review analyzes the effectiveness and drug interactions between Depakote and Advil pm. It is created by eHealthMe based on reports of 2 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 39,038 users)

Advil Pm

Advil pm has active ingredients of diphenhydramine citrate; ibuprofen. It is often used in insomnia. (latest outcomes from Advil pm 551 users)

On Oct, 15, 2016

2 people who take Depakote, Advil Pm are studied.

Number of reports submitted per year:

Depakote and Advil pm drug interactions.

Most common drug interactions by gender *:

  • oral mucosal blistering
  • pain

Most common drug interactions by age *:

  • oral mucosal blistering
  • pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote and Advil pm?

Can you answer these questions?

More questions for: Depakote, Advil pm

You may be interested in these reviews

More reviews for: Depakote, Advil pm

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Advil pm (diphenhydramine citrate; ibuprofen) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.