Review: taking Depakote and Advil pm together


Summary

Drug interactions are reported among people who take Depakote and Advil pm together. This review analyzes the effectiveness and drug interactions between Depakote and Advil pm. It is created by eHealthMe based on reports of 12 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 33,084 users)

Advil Pm

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. (latest outcomes from Advil pm 560 users)

On Aug, 21, 2016

12 people who take Depakote, Advil Pm are studied.


Number of reports submitted per year:

Depakote and Advil pm drug interactions.

Most common drug interactions over time *:

1 - 6 months:
  • hepatic enzyme increased
not specified:
  • blood creatinine increased
  • renal failure acute
  • blood urea increased
  • type 2 diabetes mellitus
  • blood cholesterol increased
  • cellulitis
  • diabetes mellitus
  • hypercholesterolaemia
  • hyponatraemia
  • hysterectomy

Most common drug interactions by gender *:

female:
  • blood cholesterol increased
  • cellulitis
  • diabetes mellitus
  • hypercholesterolaemia
  • hysterectomy
  • type 2 diabetes mellitus
  • vaginal haemorrhage
male:
  • blood creatinine increased
  • blood urea increased
  • hyponatraemia
  • renal failure acute
  • hepatic enzyme increased
  • abdominal distension
  • agitation
  • anaemia
  • confusion
  • diabetic ketoacidosis

Most common drug interactions by age *:

10-19:
  • abdominal distension
  • anaemia
  • drug level increased
  • endocarditis
  • grey syndrome neonatal
  • lethargy
  • metabolic acidosis
  • neuropathy peripheral
  • neutropenia
  • osteomyelitis
20-29:
  • diabetic ketoacidosis
  • pancreatitis acute
  • type 2 diabetes mellitus
30-39:
  • blood cholesterol increased
  • cellulitis
  • diabetes mellitus
  • hypercholesterolaemia
  • hysterectomy
  • type 2 diabetes mellitus
  • vaginal haemorrhage
40-49:
  • renal failure acute
  • excessive masturbation
  • inappropriate affect
  • mania
  • blood creatinine increased
  • blood urea increased
  • hyponatraemia
50-59:
  • hepatic enzyme increased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Advil pm (diphenhydramine hydrochloride; ibuprofen) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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