Review: taking Depakote and Olanzapine together


Summary

Drug interactions are reported among people who take Depakote and Olanzapine together. This review analyzes the effectiveness and drug interactions between Depakote and Olanzapine. It is created by eHealthMe based on reports of 4,497 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 30,578 users)

Olanzapine

Olanzapine has active ingredients of olanzapine. It is often used in schizophrenia. (latest outcomes from Olanzapine 11,914 users)

On Jul, 21, 2016

4,497 people who take Depakote, Olanzapine are studied.


Number of reports submitted per year:

Depakote and Olanzapine drug interactions.

Drug effectiveness over time:

Depakote:
  • < 1 month: 0.0% - (0 of 9 people)
  • 1 - 6 months: 10.0% - (1 of 10 people)
  • 6 - 12 months: 20.0% - (1 of 5 people)
  • 1 - 2 years: 0.0% - (0 of 5 people)
  • 2 - 5 years: 18.0% - (2 of 11 people)
  • 5 - 10 years: 50.0% - (3 of 6 people)
  • 10+ years: 20.0% - (1 of 5 people)
  • not specified: 0.0% - (0 of 0 people)
Olanzapine:
  • < 1 month: 22.0% - (2 of 9 people)
  • 1 - 6 months: 7.0% - (1 of 13 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 0.0% - (0 of 3 people)
  • 2 - 5 years: 14.0% - (1 of 7 people)
  • 5 - 10 years: 100.0% - (4 of 4 people)
  • 10+ years: 75.0% - (3 of 4 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Depakote:
  • female: 13.0% - (3 of 22 people)
  • male: 17.0% - (5 of 29 people)
Olanzapine:
  • female: 14.0% - (3 of 21 people)
  • male: 35.0% - (10 of 28 people)

Drug effectiveness by age:

Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 0.0% - (0 of 4 people)
  • 20-29: 25.0% - (3 of 12 people)
  • 30-39: 11.0% - (1 of 9 people)
  • 40-49: 10.0% - (1 of 10 people)
  • 50-59: 25.0% - (2 of 8 people)
  • 60+: 16.0% - (1 of 6 people)
Olanzapine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 25.0% - (1 of 4 people)
  • 20-29: 33.0% - (4 of 12 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 14.0% - (1 of 7 people)
  • 50-59: 33.0% - (3 of 9 people)
  • 60+: 28.0% - (2 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • blood triglycerides increased
  • overdose
  • blood cholesterol increased
  • diabetes mellitus
  • blood glucose increased
  • confusional state
  • type 2 diabetes mellitus
  • weight increased
  • coma
  • disorientation
1 - 6 months:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • weight increased
  • blood triglycerides increased
  • blood cholesterol increased
  • chest pain
  • hyperglycaemia
  • diabetic ketoacidosis
  • suicidal ideation
  • hypertension
6 - 12 months:
  • diabetes mellitus
  • weight increased
  • type 2 diabetes mellitus
  • blood cholesterol increased
  • hypertension
  • pancreatitis
  • blood triglycerides increased
  • hyperglycaemia
  • obesity
  • depression
1 - 2 years:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • hypertension
  • hyperglycaemia
  • blood triglycerides increased
  • blood cholesterol increased
  • obesity
  • diabetic ketoacidosis
  • pancreatitis
2 - 5 years:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • hyperglycaemia
  • obesity
  • chest pain
  • pancreatitis
  • hypertension
  • blood cholesterol increased
  • neuropathy peripheral
5 - 10 years:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • hypertension
  • obesity
  • hyperglycaemia
  • blood triglycerides increased
  • diabetic coma
  • diabetic ketoacidosis
  • blood cholesterol increased
10+ years:
  • weight increased
  • type 2 diabetes mellitus
  • diabetes mellitus
  • obesity
  • thrombosis
  • blood cholesterol increased
  • breast mass
  • perirectal abscess
  • anticoagulation drug level above therapeutic
  • diabetes mellitus inadequate control
not specified:
  • diabetes mellitus
  • weight increased
  • type 2 diabetes mellitus
  • overdose
  • pancreatitis
  • hypertension
  • blood cholesterol increased
  • hyperglycaemia
  • chest pain
  • obesity

Most common drug interactions by gender *:

female:
  • diabetes mellitus
  • weight increased
  • type 2 diabetes mellitus
  • blood cholesterol increased
  • obesity
  • hypertension
  • blood triglycerides increased
  • hyperglycaemia
  • pancreatitis
  • diabetic ketoacidosis
male:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • overdose
  • chest pain
  • hypertension
  • blood cholesterol increased
  • diabetic ketoacidosis
  • blood triglycerides increased
  • hyperglycaemia

Most common drug interactions by age *:

0-1:
  • apgar score low
  • convulsion
  • developmental delay
  • drug exposure during pregnancy
  • muscular weakness
  • type 2 diabetes mellitus
  • abdominal pain
  • aggression
  • cerebrovascular accident
  • depression
2-9:
  • aggression
  • weight increased
  • bipolar disorder
  • convulsion
  • intentional self-injury
  • mania
  • agitation
  • homicidal ideation
  • bite
  • depression
10-19:
  • agitation
  • weight increased
  • suicidal ideation
  • abnormal behaviour
  • aggression
  • mania
  • type 2 diabetes mellitus
  • depression
  • overdose
  • vomiting
20-29:
  • weight increased
  • diabetes mellitus
  • type 2 diabetes mellitus
  • diabetic ketoacidosis
  • overdose
  • hyperglycaemia
  • blood cholesterol increased
  • sedation
  • pancreatitis
  • obesity
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • obesity
  • blood cholesterol increased
  • hyperglycaemia
  • blood triglycerides increased
  • diabetes mellitus inadequate control
  • pancreatitis
  • diabetic ketoacidosis
40-49:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • chest pain
  • blood cholesterol increased
  • blood triglycerides increased
  • hypertension
  • hyperglycaemia
  • confusional state
  • anxiety
50-59:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight increased
  • blood cholesterol increased
  • blood triglycerides increased
  • overdose
  • hypertension
  • obesity
  • insomnia
  • chest pain
60+:
  • diabetes mellitus
  • tremor
  • confusional state
  • weight increased
  • fall
  • hypertension
  • hypotension
  • type 2 diabetes mellitus
  • dehydration
  • urinary tract infection

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Olanzapine (olanzapine) is often used to treat schizophrenia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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