Review: taking Depakote and Trazodone hydrochloride together


Summary

Drug interactions are reported among people who take Depakote and Trazodone hydrochloride together. This review analyzes the effectiveness and drug interactions between Depakote and Trazodone hydrochloride. It is created by eHealthMe based on reports of 2,044 people who take the same drugs from FDA and social media, and is updated regularly.

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Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 38,406 users)

Trazodone Hydrochloride

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from Trazodone hydrochloride 8,505 users)

On Sep, 19, 2016

2,044 people who take Depakote, Trazodone Hydrochloride are studied.


Number of reports submitted per year:

Depakote and Trazodone hydrochloride drug interactions.

Drug effectiveness over time:

Depakote:
  • < 1 month: 42.0% - (3 of 7 people)
  • 1 - 6 months: 14.0% - (2 of 14 people)
  • 6 - 12 months: 14.0% - (1 of 7 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 46.0% - (6 of 13 people)
  • 5 - 10 years: 57.0% - (4 of 7 people)
  • 10+ years: 80.0% - (4 of 5 people)
  • not specified: 100.0% - (1 of 1 people)
Trazodone Hydrochloride:
  • < 1 month: 28.0% - (2 of 7 people)
  • 1 - 6 months: 23.0% - (4 of 17 people)
  • 6 - 12 months: 0.0% - (0 of 8 people)
  • 1 - 2 years: 33.0% - (3 of 9 people)
  • 2 - 5 years: 41.0% - (5 of 12 people)
  • 5 - 10 years: 57.0% - (4 of 7 people)
  • 10+ years: 50.0% - (2 of 4 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Depakote:
  • female: 39.0% - (17 of 43 people)
  • male: 33.0% - (6 of 18 people)
Trazodone Hydrochloride:
  • female: 29.0% - (13 of 44 people)
  • male: 35.0% - (7 of 20 people)

Drug effectiveness by age:

Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 40.0% - (4 of 10 people)
  • 30-39: 66.0% - (10 of 15 people)
  • 40-49: 18.0% - (3 of 16 people)
  • 50-59: 30.0% - (3 of 10 people)
  • 60+: 28.0% - (2 of 7 people)
Trazodone Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 33.0% - (3 of 9 people)
  • 30-39: 40.0% - (6 of 15 people)
  • 40-49: 21.0% - (4 of 19 people)
  • 50-59: 30.0% - (3 of 10 people)
  • 60+: 37.0% - (3 of 8 people)

Most common drug interactions over time *:

< 1 month:
  • blood cholesterol increased
  • blood triglycerides increased
  • haematocrit decreased
  • haemoglobin decreased
  • blood glucose increased
  • confusional state
  • granulocytopenia
  • overdose
  • depression
  • urinary incontinence
1 - 6 months:
  • aggression
  • drug exposure during pregnancy
  • ventricular septal defect
  • atrial septal defect
  • pain
  • anaemia
  • anxiety
  • apnoea
  • foetal distress syndrome
  • respiratory distress
6 - 12 months:
  • type 2 diabetes mellitus
  • pain
  • diabetes mellitus
  • nausea
  • anxiety
  • back pain
  • cerebral infarction
  • emotional distress
  • gastrooesophageal reflux disease
  • general physical health deterioration
1 - 2 years:
  • back pain
  • type 2 diabetes mellitus
  • blood cholesterol increased
  • diabetic neuropathy
  • neuropathy peripheral
  • aggression
  • appendicitis
  • blood triglycerides increased
  • diabetic ketoacidosis
  • musculoskeletal disorder
2 - 5 years:
  • drug exposure during pregnancy
  • ventricular septal defect
  • atrial septal defect
  • type 2 diabetes mellitus
  • respiratory distress
  • anaemia
  • apnoea
  • diabetes mellitus
  • foetal distress syndrome
  • anxiety
5 - 10 years:
  • obesity
  • type 2 diabetes mellitus
  • diabetes mellitus
  • back pain
  • adverse drug reaction
  • nausea
  • pancreatitis
  • abdominal pain upper
  • hyperglycaemia
  • weight increased
10+ years:
  • weight increased
  • diabetes mellitus inadequate control
  • hypertension aggravated
  • blood glucose increased
  • diabetic neuropathy
  • diabetic retinopathy
  • obesity
  • proteinuria
  • renal disorder
  • blood cholesterol increased
not specified:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • nausea
  • weight increased
  • fatigue
  • depression
  • headache
  • dizziness
  • tremor
  • suicidal ideation

Most common drug interactions by gender *:

female:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • nausea
  • weight increased
  • headache
  • depression
  • dizziness
  • anxiety
  • pain
  • tremor
male:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • fatigue
  • aggression
  • suicidal ideation
  • weight increased
  • tremor
  • agitation
  • nausea
  • chest pain

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • aggression
  • convulsion
  • muscular weakness
  • tremor
  • cardiac tamponade
  • chronic kidney disease
  • chronic respiratory failure
  • congenital tracheomalacia
  • deep vein thrombosis
2-9:
  • aggression
  • intentional self-injury
  • screaming
  • suicidal behaviour
  • dyspnoea
  • agitation
  • bipolar disorder
  • bite
  • convulsion
  • depression
10-19:
  • aggression
  • affective disorder
  • agitation
  • suicidal ideation
  • weight increased
  • sleep disorder
  • neuroleptic malignant syndrome
  • compartment syndrome
  • drug administration error
  • extremity necrosis
20-29:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • weight increased
  • dizziness
  • blood cholesterol increased
  • headache
  • suicidal ideation
  • abdominal pain
  • anxiety
  • anger
30-39:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • nausea
  • obesity
  • weight increased
  • hypertension
  • pain
  • depression
  • vision blurred
  • blood cholesterol increased
40-49:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • nausea
  • neuropathy peripheral
  • fatigue
  • weight increased
  • blood cholesterol increased
  • chest pain
  • pain
  • blood triglycerides increased
50-59:
  • type 2 diabetes mellitus
  • diabetes mellitus
  • nausea
  • insomnia
  • dizziness
  • depression
  • neuropathy peripheral
  • obesity
  • overdose
  • tremor
60+:
  • nausea
  • fatigue
  • headache
  • dizziness
  • tremor
  • fall
  • vomiting
  • myocardial infarction
  • confusional state
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Trazodone hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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