Review: taking Diclofenac sodium and Tylenol together


Summary

Drug interactions are reported among people who take Diclofenac sodium and Tylenol together. This review analyzes the effectiveness and drug interactions between Diclofenac sodium and Tylenol. It is created by eHealthMe based on reports of 2,567 people who take the same drugs from FDA and social media, and is updated regularly.

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Diclofenac Sodium

Diclofenac sodium has active ingredients of diclofenac. It is often used in rheumatoid arthritis. (latest outcomes from Diclofenac sodium 14,574 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 63,439 users)

On Jul, 20, 2016

2,567 people who take Diclofenac Sodium, Tylenol are studied.


Number of reports submitted per year:

Diclofenac sodium and Tylenol drug interactions.

Drug effectiveness over time:

Diclofenac Sodium:
  • < 1 month: 33.0% - (4 of 12 people)
  • 1 - 6 months: 0.0% - (0 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 33.0% - (2 of 6 people)
  • 2 - 5 years: 20.0% - (1 of 5 people)
  • 5 - 10 years: 40.0% - (4 of 10 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 4 people)
Tylenol:
  • < 1 month: 25.0% - (3 of 12 people)
  • 1 - 6 months: 50.0% - (3 of 6 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 6 people)
  • 2 - 5 years: 16.0% - (1 of 6 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 40.0% - (4 of 10 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Diclofenac Sodium:
  • female: 25.0% - (10 of 39 people)
  • male: 33.0% - (3 of 9 people)
Tylenol:
  • female: 34.0% - (13 of 38 people)
  • male: 18.0% - (2 of 11 people)

Drug effectiveness by age:

Diclofenac Sodium:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 5 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 0.0% - (0 of 13 people)
  • 50-59: 46.0% - (6 of 13 people)
  • 60+: 50.0% - (7 of 14 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 7.0% - (1 of 13 people)
  • 50-59: 38.0% - (5 of 13 people)
  • 60+: 40.0% - (6 of 15 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • vomiting
  • nausea
  • diarrhoea
  • renal failure acute
  • toxic epidermal necrolysis
  • liver disorder
  • pneumonia
  • anaemia
  • abdominal pain
1 - 6 months:
  • nephrotic syndrome
  • pulmonary embolism
  • cleft palate
  • renal failure
  • renal failure acute
  • deep vein thrombosis
  • oedema peripheral
  • pyrexia
  • abdominal pain
  • asthenia
6 - 12 months:
  • aplastic anaemia
  • asthenia
  • petechiae
  • pyrexia
  • rhabdomyolysis
  • post procedural complication
  • chest pain
  • hypotension
  • multi-organ failure
  • pleural effusion
1 - 2 years:
  • aplastic anaemia
  • asthenia
  • petechiae
  • arthralgia
  • dehydration
  • oedema peripheral
  • renal failure acute
  • depression
  • diarrhoea
  • foreign body sensation in eyes
2 - 5 years:
  • blood count abnormal
  • gastrointestinal haemorrhage
  • pseudomembranous colitis
  • tinnitus
  • vitamin b12 decreased
  • fatigue
  • insomnia
  • osteomyelitis
  • osteonecrosis
  • cholestasis
5 - 10 years:
  • acute hepatic failure
  • conjunctival haemorrhage
  • hepatitis acute
  • liver function test abnormal
  • thrombosis
  • vomiting
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood albumin increased
  • blood alkaline phosphatase increased
10+ years:
  • drug administration error
  • fatigue
  • hepatitis
  • multiple drug overdose
  • swelling
  • weight increased
  • nausea
  • short-term memory loss
  • vomiting
  • abdominal pain
not specified:
  • nausea
  • pain
  • diarrhoea
  • pyrexia
  • vomiting
  • arthralgia
  • headache
  • renal failure acute
  • dehydration
  • dyspnoea

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • diarrhoea
  • vomiting
  • pyrexia
  • arthralgia
  • headache
  • dehydration
  • fatigue
  • fall
male:
  • pyrexia
  • renal failure acute
  • dyspnoea
  • vomiting
  • anaemia
  • nausea
  • hypotension
  • diarrhoea
  • pain
  • arthralgia

Most common drug interactions by age *:

0-1:
  • anaphylactic reaction
  • croup infectious
  • death
  • hypoglycaemia neonatal
  • maternal drugs affecting foetus
  • metabolic acidosis
  • neonatal tachypnoea
  • oligohydramnios
  • placental insufficiency
  • pyrexia
2-9:
  • diarrhoea
  • accidental drug intake by child
  • renal failure acute
  • renal tubular necrosis
  • skin discolouration
  • cardiac arrest
  • chemical injury
  • depressed level of consciousness
  • disseminated intravascular coagulation
  • heart rate increased
10-19:
  • vomiting
  • nausea
  • malaise
  • intentional overdose
  • diarrhoea
  • chest discomfort
  • syncope
  • pallor
  • blood glucose decreased
  • cyanosis
20-29:
  • vomiting
  • nausea
  • abdominal pain
  • convulsion
  • drug exposure during pregnancy
  • loss of consciousness
  • tachycardia
  • pyrexia
  • dehydration
  • weight decreased
30-39:
  • pyrexia
  • arthralgia
  • vomiting
  • diarrhoea
  • dyspnoea
  • maternal exposure during pregnancy
  • abdominal pain
  • renal failure acute
  • depression
  • pain
40-49:
  • nausea
  • pyrexia
  • abdominal pain
  • multi-organ failure
  • anxiety
  • chest pain
  • arthralgia
  • diarrhoea
  • vomiting
  • hypertension
50-59:
  • headache
  • diarrhoea
  • pain
  • pyrexia
  • arthralgia
  • pain in extremity
  • nausea
  • vomiting
  • anaemia
  • back pain
60+:
  • renal failure acute
  • nausea
  • dehydration
  • pain
  • confusional state
  • osteoarthritis
  • rheumatoid arthritis
  • asthma
  • diarrhoea
  • pyrexia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Diclofenac sodium (diclofenac) is often used to treat rheumatoid arthritis. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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