Review: taking Dilantin and Depakote together


Summary

Drug interactions are reported among people who take Dilantin and Depakote together. This review analyzes the effectiveness and drug interactions between Dilantin and Depakote. It is created by eHealthMe based on reports of 1,306 people who take the same drugs from FDA and social media, and is updated regularly.

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Dilantin

Dilantin has active ingredients of phenytoin sodium. It is often used in convulsion. (latest outcomes from Dilantin 19,121 users)

Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 33,660 users)

On Aug, 26, 2016

1,306 people who take Dilantin, Depakote are studied.


Number of reports submitted per year:

Dilantin and Depakote drug interactions.

Drug effectiveness over time:

Dilantin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 66.0% - (2 of 3 people)
  • 10+ years: 76.0% - (10 of 13 people)
  • not specified: 0.0% - (0 of 0 people)
Depakote:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 75.0% - (6 of 8 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Dilantin:
  • female: 57.0% - (4 of 7 people)
  • male: 81.0% - (9 of 11 people)
Depakote:
  • female: 37.0% - (3 of 8 people)
  • male: 58.0% - (7 of 12 people)

Drug effectiveness by age:

Dilantin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 77.0% - (7 of 9 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)
Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 55.0% - (5 of 9 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • convulsion
  • stevens-johnson syndrome
  • fatigue
  • memory impairment
  • toxic epidermal necrolysis
  • anxiety
  • confusional state
  • dizziness
  • drug ineffective
  • granulocytopenia
1 - 6 months:
  • convulsion
  • stevens-johnson syndrome
  • drug hypersensitivity
  • drug ineffective
  • pyrexia
  • back pain
  • cerebral arteriovenous malformation haemorrhagic
  • hypersensitivity
  • fall
  • postictal state
6 - 12 months:
  • dizziness
  • fatigue
  • headache
  • oedema peripheral
  • weight increased
  • alopecia
  • anxiety
  • apraxia
  • arthralgia
  • bone density decreased
1 - 2 years:
  • dizziness
  • fatigue
  • hypoaesthesia
  • convulsion
  • memory impairment
  • nausea
  • weight increased
  • headache
  • oedema peripheral
  • anxiety
2 - 5 years:
  • convulsion
  • back pain
  • blood cholesterol increased
  • cholelithiasis
  • hyperlipidaemia
  • limb injury
  • type 2 diabetes mellitus
  • alopecia
  • ataxia
  • diabetes mellitus
5 - 10 years:
  • convulsion
  • dizziness
  • blood count abnormal
  • burning sensation
  • cystitis
  • drug ineffective
  • headache
  • loss of consciousness
  • palpitations
  • weight decreased
10+ years:
  • abnormal dreams
  • abnormal loss of weight
  • amnesia
  • anxiety
  • decreased appetite
  • hypoglycaemia
  • memory impairment
  • vitamin c deficiency
  • convulsion
  • dizziness
not specified:
  • convulsion
  • dizziness
  • headache
  • weight decreased
  • loss of consciousness
  • drug ineffective
  • pain
  • tremor
  • grand mal convulsion
  • amnesia

Most common drug interactions by gender *:

female:
  • convulsion
  • headache
  • dizziness
  • weight decreased
  • loss of consciousness
  • tremor
  • pain
  • amnesia
  • drug ineffective
  • anxiety
male:
  • convulsion
  • drug ineffective
  • grand mal convulsion
  • dizziness
  • fall
  • anticonvulsant drug level increased
  • rash
  • depression
  • loss of consciousness
  • weight decreased

Most common drug interactions by age *:

0-1:
  • stevens-johnson syndrome
  • brain stem syndrome
  • convulsion
  • convulsion neonatal
  • demyelination
  • drug exposure during pregnancy
  • drug ineffective
  • facial dysmorphism
  • feeling jittery
  • foetal hydantoin syndrome
2-9:
  • nausea
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • vomiting
  • alanine aminotransferase increased
  • asthenia
  • dehydration
  • liver function test abnormal
  • multiple sclerosis
  • appetite decreased
10-19:
  • grand mal convulsion
  • sedation
  • blood cholesterol increased
  • convulsion
  • headache
  • stevens-johnson syndrome
  • weight increased
  • abdominal distension
  • gastrooesophageal reflux disease
  • gingival swelling
20-29:
  • convulsion
  • stevens-johnson syndrome
  • drug ineffective
  • granulocytopenia
  • activities of daily living impaired
  • diabetes mellitus
  • anger
  • weight increased
  • anticonvulsant drug level decreased
  • dizziness
30-39:
  • convulsion
  • type 2 diabetes mellitus
  • diabetic neuropathy
  • anxiety
  • memory impairment
  • abnormal loss of weight
  • hypoglycaemia
  • amnesia
  • obesity
  • pain
40-49:
  • convulsion
  • vomiting
  • weight decreased
  • rash
  • tremor
  • amnesia
  • fatigue
  • headache
  • dizziness
  • drug ineffective
50-59:
  • convulsion
  • weight decreased
  • loss of consciousness
  • dizziness
  • headache
  • drug ineffective
  • pain
  • fall
  • insomnia
  • palpitations
60+:
  • dizziness
  • convulsion
  • loss of consciousness
  • weight decreased
  • blood pressure increased
  • headache
  • burning sensation
  • cystitis
  • ingrowing nail
  • tremor

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Dilantin (phenytoin sodium) is often used to treat convulsion. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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