Review: taking Dilantin and Depakote together


Summary

Drug interactions are reported among people who take Dilantin and Depakote together. This review analyzes the effectiveness and drug interactions between Dilantin and Depakote. It is created by eHealthMe based on reports of 1,517 people who take the same drugs from FDA and social media, and is updated regularly.

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Dilantin

Dilantin has active ingredients of phenytoin. It is often used in convulsion. (latest outcomes from Dilantin 4,823 users)

Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 38,406 users)

On Sep, 25, 2016

1,517 people who take Dilantin, Depakote are studied.


Number of reports submitted per year:

Dilantin and Depakote drug interactions.

Drug effectiveness over time:

Dilantin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 66.0% - (2 of 3 people)
  • 10+ years: 76.0% - (10 of 13 people)
  • not specified: 0.0% - (0 of 0 people)
Depakote:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 75.0% - (6 of 8 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Dilantin:
  • female: 57.0% - (4 of 7 people)
  • male: 81.0% - (9 of 11 people)
Depakote:
  • female: 37.0% - (3 of 8 people)
  • male: 58.0% - (7 of 12 people)

Drug effectiveness by age:

Dilantin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 77.0% - (7 of 9 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)
Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 55.0% - (5 of 9 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • convulsion
  • stevens-johnson syndrome
  • fatigue
  • memory impairment
  • toxic epidermal necrolysis
  • anxiety
  • confusional state
  • dizziness
  • drug ineffective
  • granulocytopenia
1 - 6 months:
  • convulsion
  • stevens-johnson syndrome
  • drug hypersensitivity
  • drug ineffective
  • pyrexia
  • back pain
  • cerebral arteriovenous malformation haemorrhagic
  • fall
  • hypersensitivity
  • dizziness
6 - 12 months:
  • dizziness
  • fatigue
  • headache
  • oedema peripheral
  • weight increased
  • alopecia
  • anxiety
  • apraxia
  • arthralgia
  • bone density decreased
1 - 2 years:
  • dizziness
  • fatigue
  • hypoaesthesia
  • weight increased
  • convulsion
  • memory impairment
  • nausea
  • headache
  • oedema peripheral
  • spinal fracture
2 - 5 years:
  • convulsion
  • back pain
  • blood cholesterol increased
  • cholelithiasis
  • headache
  • hyperlipidaemia
  • limb injury
  • tremor
  • type 2 diabetes mellitus
  • weight increased
5 - 10 years:
  • convulsion
  • dizziness
  • blood count abnormal
  • burning sensation
  • cystitis
  • drug ineffective
  • headache
  • loss of consciousness
  • palpitations
  • weight decreased
10+ years:
  • dizziness
  • abnormal dreams
  • abnormal loss of weight
  • amnesia
  • anxiety
  • aphonia
  • convulsion
  • decreased appetite
  • drug ineffective
  • glare
not specified:
  • convulsion
  • drug ineffective
  • dizziness
  • headache
  • tremor
  • fall
  • amnesia
  • fatigue
  • memory impairment
  • weight decreased

Most common drug interactions by gender *:

female:
  • convulsion
  • headache
  • dizziness
  • drug ineffective
  • tremor
  • amnesia
  • fatigue
  • memory impairment
  • fall
  • gait disturbance
male:
  • convulsion
  • drug ineffective
  • dizziness
  • grand mal convulsion
  • fall
  • weight decreased
  • tremor
  • vomiting
  • lethargy
  • rash

Most common drug interactions by age *:

0-1:
  • stevens-johnson syndrome
  • brain stem syndrome
  • convulsion
  • convulsion neonatal
  • demyelination
  • drug exposure during pregnancy
  • drug ineffective
  • facial dysmorphism
  • feeling jittery
  • foetal hydantoin syndrome
2-9:
  • nausea
  • vomiting
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • alanine aminotransferase increased
  • asthenia
  • tremor
  • dehydration
  • liver function test abnormal
  • multiple sclerosis
10-19:
  • grand mal convulsion
  • convulsion
  • sedation
  • blood cholesterol increased
  • headache
  • stevens-johnson syndrome
  • weight increased
  • abdominal distension
  • gastrooesophageal reflux disease
  • gingival swelling
20-29:
  • convulsion
  • drug ineffective
  • stevens-johnson syndrome
  • granulocytopenia
  • headache
  • seizure
  • dizziness
  • loss of consciousness
  • fall
  • anger
30-39:
  • convulsion
  • type 2 diabetes mellitus
  • anxiety
  • diabetic neuropathy
  • memory impairment
  • pain
  • abnormal loss of weight
  • hypoglycaemia
  • amnesia
  • obesity
40-49:
  • convulsion
  • vomiting
  • weight decreased
  • tremor
  • dizziness
  • nausea
  • headache
  • rash
  • amnesia
  • fatigue
50-59:
  • convulsion
  • weight decreased
  • dizziness
  • loss of consciousness
  • headache
  • drug ineffective
  • pain
  • fall
  • insomnia
  • drug hypersensitivity
60+:
  • convulsion
  • dizziness
  • tremor
  • drug ineffective
  • loss of consciousness
  • pain
  • diarrhoea
  • weight decreased
  • blood pressure increased
  • drug hypersensitivity

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Dilantin (phenytoin) is often used to treat convulsion. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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