Review: taking Dilantin and Depakote together


Summary

Drug interactions are reported among people who take Dilantin and Depakote together. This review analyzes the effectiveness and drug interactions between Dilantin and Depakote. It is created by eHealthMe based on reports of 1,156 people who take the same drugs from FDA and social media, and is updated regularly.

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Dilantin

Dilantin has active ingredients of phenytoin. It is often used in convulsion. (latest outcomes from Dilantin 20,037 users)

Depakote

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 30,545 users)

On Jul, 30, 2016

1,156 people who take Dilantin, Depakote are studied.


Number of reports submitted per year:

Dilantin and Depakote drug interactions.

Drug effectiveness over time:

Dilantin:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 75.0% - (3 of 4 people)
  • 10+ years: 78.0% - (11 of 14 people)
  • not specified: 0.0% - (0 of 0 people)
Depakote:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 33.0% - (1 of 3 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 3 people)
  • 2 - 5 years: 50.0% - (2 of 4 people)
  • 5 - 10 years: 0.0% - (0 of 2 people)
  • 10+ years: 77.0% - (7 of 9 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Dilantin:
  • female: 62.0% - (5 of 8 people)
  • male: 83.0% - (10 of 12 people)
Depakote:
  • female: 44.0% - (4 of 9 people)
  • male: 53.0% - (7 of 13 people)

Drug effectiveness by age:

Dilantin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 80.0% - (8 of 10 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 100.0% - (1 of 1 people)
Depakote:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 100.0% - (3 of 3 people)
  • 40-49: 60.0% - (6 of 10 people)
  • 50-59: 0.0% - (0 of 3 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • convulsion
  • stevens-johnson syndrome
  • memory impairment
  • anxiety
  • confusional state
  • dizziness
  • fatigue
  • granulocytopenia
  • headache
  • toxic epidermal necrolysis
1 - 6 months:
  • convulsion
  • stevens-johnson syndrome
  • drug hypersensitivity
  • pyrexia
  • drug ineffective
  • back pain
  • cerebral arteriovenous malformation haemorrhagic
  • hypersensitivity
  • postictal state
  • asthenia
6 - 12 months:
  • anxiety
  • apraxia
  • arthralgia
  • bone density decreased
  • confusional state
  • convulsion
  • coordination abnormal
  • dizziness
  • fatigue
  • gamma-glutamyltransferase increased
1 - 2 years:
  • dizziness
  • convulsion
  • memory impairment
  • nausea
  • weight increased
  • anxiety
  • apraxia
  • arthralgia
  • bone density decreased
  • confusional state
2 - 5 years:
  • back pain
  • blood cholesterol increased
  • cholelithiasis
  • convulsion
  • hyperlipidaemia
  • limb injury
  • type 2 diabetes mellitus
  • alopecia
  • ataxia
  • diabetes mellitus
5 - 10 years:
  • convulsion
  • dizziness
  • blood count abnormal
  • burning sensation
  • cystitis
  • drug ineffective
  • full blood count decreased
  • gastric disorder
  • headache
  • loss of consciousness
10+ years:
  • abnormal dreams
  • abnormal loss of weight
  • amnesia
  • anxiety
  • decreased appetite
  • hypoglycaemia
  • memory impairment
  • vitamin c deficiency
  • convulsion
  • dizziness
not specified:
  • convulsion
  • dizziness
  • headache
  • loss of consciousness
  • weight decreased
  • grand mal convulsion
  • nausea
  • drug ineffective
  • anxiety
  • amnesia

Most common drug interactions by gender *:

female:
  • convulsion
  • headache
  • dizziness
  • weight decreased
  • loss of consciousness
  • nausea
  • anxiety
  • palpitations
  • cystitis
  • amnesia
male:
  • convulsion
  • grand mal convulsion
  • dizziness
  • drug ineffective
  • anticonvulsant drug level increased
  • loss of consciousness
  • diabetes mellitus
  • rash
  • type 2 diabetes mellitus
  • memory impairment

Most common drug interactions by age *:

0-1:
  • stevens-johnson syndrome
  • convulsion
  • convulsion neonatal
  • drug exposure during pregnancy
  • drug ineffective
  • facial dysmorphism
  • feeling jittery
  • foetal hydantoin syndrome
  • maternal drugs affecting foetus
  • premature baby
2-9:
  • nausea
  • aspartate aminotransferase increased
  • blood bilirubin increased
  • vomiting
  • alanine aminotransferase increased
  • asthenia
  • dehydration
  • liver function test abnormal
  • multiple sclerosis
  • appetite decreased
10-19:
  • grand mal convulsion
  • sedation
  • blood cholesterol increased
  • headache
  • stevens-johnson syndrome
  • weight increased
  • abdominal distension
  • gastrooesophageal reflux disease
  • gingival swelling
  • glaucoma
20-29:
  • convulsion
  • stevens-johnson syndrome
  • granulocytopenia
  • drug ineffective
  • activities of daily living impaired
  • diabetes mellitus
  • anger
  • weight increased
  • anticonvulsant drug level decreased
  • urticaria
30-39:
  • convulsion
  • type 2 diabetes mellitus
  • diabetic neuropathy
  • anxiety
  • memory impairment
  • abnormal loss of weight
  • hypoglycaemia
  • obesity
  • pain
  • renal failure
40-49:
  • convulsion
  • vomiting
  • dizziness
  • grand mal convulsion
  • confusional state
  • rash
  • amnesia
  • drug ineffective
  • nausea
  • tremor
50-59:
  • convulsion
  • dizziness
  • weight decreased
  • headache
  • loss of consciousness
  • palpitations
  • hypertension
  • burning sensation
  • arteriogram coronary abnormal
  • cystitis
60+:
  • dizziness
  • loss of consciousness
  • convulsion
  • weight decreased
  • blood pressure increased
  • burning sensation
  • cystitis
  • ingrowing nail
  • headache
  • palpitations

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Dilantin (phenytoin) is often used to treat convulsion. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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