Review: taking Diphenhydramine hydrochloride and Dimenhydrinate together


Summary

Drug interactions are reported among people who take Diphenhydramine hydrochloride and Dimenhydrinate together. This review analyzes the effectiveness and drug interactions between Diphenhydramine hydrochloride and Dimenhydrinate. It is created by eHealthMe based on reports of 310 people who take the same drugs from FDA and social media, and is updated regularly.

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Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (latest outcomes from Diphenhydramine hydrochloride 4,549 users)

Dimenhydrinate

Dimenhydrinate has active ingredients of dimenhydrinate. It is often used in nausea. (latest outcomes from Dimenhydrinate 1,263 users)

On Sep, 20, 2016

310 people who take Diphenhydramine Hydrochloride, Dimenhydrinate are studied.


Number of reports submitted per year:

Diphenhydramine hydrochloride and Dimenhydrinate drug interactions.

Drug effectiveness over time:

Diphenhydramine Hydrochloride:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Dimenhydrinate:
  • < 1 month: 60.0% - (3 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Diphenhydramine Hydrochloride:
  • female: 33.0% - (2 of 6 people)
  • male: 40.0% - (2 of 5 people)
Dimenhydrinate:
  • female: 66.0% - (4 of 6 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Diphenhydramine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)
Dimenhydrinate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 80.0% - (4 of 5 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • progressive multifocal leukoencephalopathy
  • white blood cell count decreased
  • arteriospasm coronary
  • gamma-glutamyltransferase increased
  • hepatic neoplasm
  • neutrophil count decreased
  • platelet count decreased
  • red cell distribution width increased
  • malignant neoplasm progression
  • febrile neutropenia
1 - 6 months:
  • acute respiratory distress syndrome
  • decreased appetite
  • drowsiness
  • dyspepsia
  • encephalitis
  • gastrointestinal haemorrhage
  • headache
  • infusion related reaction
  • myocardial infarction
  • nausea
6 - 12 months:
  • erectile dysfunction
  • sleep disorder due to general medical condition, insomnia type
1 - 2 years:
  • blood pressure increased
  • cardiac failure congestive
  • pain
  • weight increased
  • abscess
  • acute myeloid leukaemia
  • arthralgia
  • arthritis bacterial
  • arthropathy
  • blood pressure diastolic increased
2 - 5 years:
  • pulmonary mycosis
  • pyrexia
  • rash maculo-papular
  • arthralgia
  • chronic graft versus host disease
  • diarrhoea
  • drug ineffective
  • joint swelling
  • pain
5 - 10 years:
  • demerol overdose
  • erectile dysfunction
  • sleep disorder due to general medical condition, insomnia type
10+ years:
  • demerol overdose
not specified:
  • infusion related reaction
  • nausea
  • fatigue
  • headache
  • vomiting
  • dyspnoea
  • arthralgia
  • dizziness
  • heart rate increased
  • oxygen saturation decreased

Most common drug interactions by gender *:

female:
  • infusion related reaction
  • nausea
  • headache
  • dyspnoea
  • fatigue
  • arthralgia
  • heart rate increased
  • blood pressure increased
  • chest discomfort
  • pruritus
male:
  • dizziness
  • fatigue
  • vomiting
  • pyrexia
  • oxygen saturation decreased
  • convulsion
  • nausea
  • weight decreased
  • hypoglycaemia
  • cerebrovascular accident

Most common drug interactions by age *:

0-1:
  • brain death
  • dyspnoea
  • hyponatraemia
  • inappropriate adh secretion
2-9:
  • muscular weakness
  • aphasia
  • arthralgia
  • depressed level of consciousness
  • dysgraphia
  • excessive eye blinking
  • eyelid ptosis
  • fine motor delay
  • gait disturbance
  • neuromuscular toxicity
10-19:
  • pancytopenia
  • depressed level of consciousness
  • disseminated intravascular coagulation
  • febrile neutropenia
  • fluid overload
  • general physical health deterioration
  • haematemesis
  • hepatitis
  • hypertension
  • hypokalaemia
20-29:
  • chills
  • chest discomfort
  • infusion related reaction
  • nausea
  • abdominal pain
  • diarrhoea
  • dyspnoea
  • haemoglobin decreased
  • headache
  • dizziness
30-39:
  • infusion related reaction
  • headache
  • oxygen saturation decreased
  • vomiting
  • atelectasis
  • cardiomegaly
  • convulsion
  • pneumothorax
  • respiratory distress
  • blood potassium decreased
40-49:
  • infusion related reaction
  • pruritus
  • drug ineffective
  • joint swelling
  • blood lactate dehydrogenase increased
  • engraftment syndrome
  • escherichia infection
  • febrile neutropenia
  • headache
  • infection
50-59:
  • infusion related reaction
  • nausea
  • headache
  • heart rate increased
  • chest pain
  • febrile neutropenia
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • rash
  • arthralgia
60+:
  • arthralgia
  • progressive multifocal leukoencephalopathy
  • nausea
  • pyrexia
  • hypotension
  • myocardial infarction
  • fatigue
  • general physical health deterioration
  • constipation
  • depressed level of consciousness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Diphenhydramine hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Dimenhydrinate (dimenhydrinate) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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