Review: taking Diphenhydramine hydrochloride and Gravol together


Summary

Drug interactions are reported among people who take Diphenhydramine hydrochloride and Gravol together. This review analyzes the effectiveness and drug interactions between Diphenhydramine hydrochloride and Gravol. It is created by eHealthMe based on reports of 114 people who take the same drugs from FDA and social media, and is updated regularly.

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Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (latest outcomes from Diphenhydramine hydrochloride 2,630 users)

Gravol

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. (latest outcomes from Gravol 711 users)

On Jul, 27, 2016

114 people who take Diphenhydramine Hydrochloride, Gravol are studied.


Number of reports submitted per year:

Diphenhydramine hydrochloride and Gravol drug interactions.

Drug effectiveness over time:

Diphenhydramine Hydrochloride:
  • < 1 month: 20.0% - (1 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Gravol:
  • < 1 month: 60.0% - (3 of 5 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Diphenhydramine Hydrochloride:
  • female: 33.0% - (2 of 6 people)
  • male: 40.0% - (2 of 5 people)
Gravol:
  • female: 66.0% - (4 of 6 people)
  • male: 66.0% - (4 of 6 people)

Drug effectiveness by age:

Diphenhydramine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 60.0% - (3 of 5 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)
Gravol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 80.0% - (4 of 5 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • kidney transplant rejection
  • drowsiness
  • gastric disorder
  • acute myeloid leukaemia
  • cardiac failure congestive
  • disease progression
  • ejection fraction decreased
  • lethargy
  • mucosal inflammation
  • nausea
1 - 6 months:
  • drowsiness
  • nausea
  • vertigo
6 - 12 months:
  • erectile dysfunction
  • sleep disorder due to general medical condition, insomnia type
1 - 2 years:
  • oedema
  • acute myeloid leukaemia
  • cardiac failure congestive
  • disease progression
  • ejection fraction decreased
  • lethargy
  • mucosal inflammation
5 - 10 years:
  • demerol overdose
  • erectile dysfunction
  • sleep disorder due to general medical condition, insomnia type
10+ years:
  • demerol overdose
not specified:
  • fatigue
  • vomiting
  • depressed level of consciousness
  • febrile neutropenia
  • nausea
  • dizziness
  • cerebrovascular accident
  • diabetic coma
  • pleural effusion
  • pyrexia

Most common drug interactions by gender *:

female:
  • febrile neutropenia
  • nausea
  • pleural effusion
  • blood creatinine increased
  • blood pressure decreased
  • depressed level of consciousness
  • hypotension
  • infusion related reaction
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
male:
  • cerebrovascular accident
  • diabetic coma
  • dizziness
  • fatigue
  • vomiting
  • weight decreased
  • hypoglycaemia
  • pyrexia
  • depressed level of consciousness
  • nausea

Most common drug interactions by age *:

0-1:
  • hyponatraemia
  • inappropriate adh secretion
2-9:
  • aphasia
  • depressed level of consciousness
  • excessive eye blinking
  • neurotoxicity
  • staring
  • unresponsive to stimuli
  • urinary incontinence
10-19:
  • depressed level of consciousness
  • disseminated intravascular coagulation
  • febrile neutropenia
  • fluid overload
  • general physical health deterioration
  • haematemesis
  • hepatitis
  • hypertension
  • hypokalaemia
  • hypomagnesaemia
20-29:
  • completed suicide
  • abdominal pain upper
  • arthralgia
  • blood pressure decreased
  • chest discomfort
  • death
  • dizziness
  • drowsiness
  • electrocardiogram qrs complex prolonged
  • electrocardiogram qrs complex shortened
30-39:
  • cerebral haemorrhage
  • chest discomfort
  • contusion
  • depressed level of consciousness
  • drug hypersensitivity
  • dry throat
  • ephelides
  • haematuria
  • hypoxia
  • infusion related reaction
40-49:
  • blood lactate dehydrogenase increased
  • engraftment syndrome
  • febrile neutropenia
  • lung infiltration
  • pericardial effusion
  • pleural effusion
  • convulsion
  • dysphagia
  • infection
  • kidney transplant rejection
50-59:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood alkaline phosphatase increased
  • blood creatinine increased
  • febrile neutropenia
  • blood pressure decreased
  • gastrointestinal inflammation
  • hypersensitivity
  • ileus
  • klebsiella bacteraemia
60+:
  • depressed level of consciousness
  • fluid overload
  • myocardial infarction
  • cardiac arrest
  • neutropenia
  • oliguria
  • pleural effusion
  • renal transplant
  • ventricular fibrillation
  • benign prostatic hyperplasia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Diphenhydramine hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Gravol (dimenhydrinate) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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